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View Structure Prediction Details

Protein: CD3D
Organism: Homo sapiens
Length: 171 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CD3D.

Description E-value Query
Range
Subject
Range
gi|74150307 - gi|74150307|dbj|BAE32208.1| unnamed protein product [Mus musculus]
2.0E-45 [1..171] [1..171]
gi|109108856 - gi|109108856|ref|XP_001097302.1| PREDICTED: CD3d molecule, delta (CD3-TCR complex) [Macaca mulatta]
1.0E-44 [1..171] [1..171]
CD3D_MACFA - T-cell surface glycoprotein CD3 delta chain OS=Macaca fascicularis GN=CD3D PE=2 SV=1
1.0E-44 [1..171] [1..171]
CD3D_RAT - T-cell surface glycoprotein CD3 delta chain OS=Rattus norvegicus GN=Cd3d PE=2 SV=1
7.0E-44 [1..171] [1..171]
gi|224309 - gi|224309|prf||1101394A protein delta T3,glyco
2.0E-43 [1..171] [1..171]
gi|114640611 - gi|114640611|ref|XP_508789.2| PREDICTED: hypothetical protein [Pan troglodytes]
2.0E-43 [1..171] [1..171]
gi|57085933 - gi|57085933|ref|XP_536556.1| PREDICTED: similar to T-cell surface glycoprotein CD3 delta chain precu...
1.0E-41 [1..171] [1..171]

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Predicted Domain #1
Region A:
Residues: [1-99]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEHSTFLSGL VLATLLSQVS PFKIPIEELE DRVFVNCNTS ITWVEGTVGT LLSDITRLDL  60
   61 GKRILDPRGI YRCNGTDIYK DKESTVQVHY RMCQSCVEL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.69897
Match: 1xiwB
Description: Crystal structure of human CD3-e/d dimer in complex with a UCHT1 single-chain antibody fragment
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
receptor activity 4.00123250685257 bayes_pls_golite062009
transmembrane receptor activity 3.81769911097805 bayes_pls_golite062009
antigen binding 3.16266926144655 bayes_pls_golite062009
molecular transducer activity 3.10913345555941 bayes_pls_golite062009
signal transducer activity 3.10913345555941 bayes_pls_golite062009
binding 2.53652619212064 bayes_pls_golite062009
T cell receptor binding 2.12089279430732 bayes_pls_golite062009
peptide antigen binding 1.66960790017756 bayes_pls_golite062009
protein binding 1.17809977833322 bayes_pls_golite062009
G-protein coupled receptor activity 1.02428106476324 bayes_pls_golite062009
receptor binding 0.909733688848793 bayes_pls_golite062009
immunoglobulin binding 0.84834833214265 bayes_pls_golite062009
protein complex binding 0.83543827718565 bayes_pls_golite062009
peptide binding 0.729048089532569 bayes_pls_golite062009
coreceptor activity 0.661209696849389 bayes_pls_golite062009
growth factor binding 0.53454839799174 bayes_pls_golite062009
transmembrane receptor protein kinase activity 0.447829399094714 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 0.28309679787333 bayes_pls_golite062009
olfactory receptor activity 0.20101044847022 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [100-171]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DPATVAGIIV TDVIATLLLA LGVFCFAGHE TGRLSGAADT QALLRNDQVY QPLRDRDDAQ  60
   61 YSHLGGNWAR NK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.343 0.046 positive thymic T cell selection a.77.1 DEATH domain
View Download 0.442 0.023 positive thymic T cell selection a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.274 0.010 positive thymic T cell selection d.68.3 SirA-like
View Download 0.275 0.007 positive thymic T cell selection d.58.10 Acylphosphatase-like
View Download 0.364 0.003 positive thymic T cell selection a.23.4 Mitochondrial import receptor subunit Tom20


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle