YRC Public Data Repository - Protein Structure Prediction

Protein:	PTGES3
Organism:	Homo sapiens
Length:	160 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PTGES3.

Description	E-value	Query Range	Subject Range
gi\|73968408 - gi\|73968408\|ref\|XP_848910.1\| PREDICTED: similar to unactive progesterone receptor, 23 kD [Canis fami...	2.0E-54	[1..160]	[341..500]
gi\|50804055 - gi\|50804055\|ref\|XP_424297.1\| PREDICTED: similar to Hypothetical protein KIAA0286 (HA6800), partial [...	5.0E-53	[2..160]	[1722..1880]
gi\|51493666 - gi\|51493666\|gb\|AAU04847.1\| cytosolic prostaglandin E synthase [Bos taurus]	4.0E-43	[1..160]	[1..160]
gi\|114590198, gi... - gi\|114590200\|ref\|XP_001159134.1\| PREDICTED: similar to p23 isoform 2 [Pan troglodytes], gi\|114590198...	2.0E-42	[1..160]	[1..160]
gi\|74195420 - gi\|74195420\|dbj\|BAE39529.1\| unnamed protein product [Mus musculus]	4.0E-42	[1..160]	[1..160]
gi\|88981297, gi\|... - gi\|88981297\|ref\|XP_944613.1\| PREDICTED: similar to unactive progesterone receptor, 23 kD [Homo sapie...	1.0E-41	[1..160]	[1..160]
gi\|28422407, gi\|... - gi\|28422407\|gb\|AAH44075.1\| Tebp-pending-prov protein [Xenopus laevis], gi\|148228297\|ref\|NP_001080608...	2.0E-41	[1..160]	[1..160]

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Predicted Domain #1

Region A:
Residues: [1-160]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQPASAKWYD RRDYVFIEFC VEDSKDVNVN FEKSKLTFSC LGGSDNFKHL NEIDLFHCID  60
   61 PNDSKHKRTD RSILCCLRKG ESGQSWPRLT KERAKLNWLS VDFNNWKDWE DDSDEDMSNF 120
  121 DRFSEMMNNM GGDEDVDLPE VDGADDDSQD SDDEKMPDLE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	34.045757
Match:	1ejfA
Description:	Co-chaperone p23
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
telomerase activity	8.07977960347395	bayes_pls_golite062009
RNA-directed DNA polymerase activity	7.72023695647402	bayes_pls_golite062009
binding	1.9759530321894	bayes_pls_golite062009
prostaglandin-E synthase activity	1.35618568352138	bayes_pls_golite062009
protein binding	0.743263427072441	bayes_pls_golite062009
catalytic activity	0.260308151913118	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: