| Protein: | XRN2 |
| Organism: | Homo sapiens |
| Length: | 950 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for XRN2.
| Description | E-value | Query Range |
Subject Range |
|
|
0.0 | [1..950] | [1..950] |
|
|
0.0 | [1..950] | [1..950] |
|
|
0.0 | [1..950] | [1..950] |
|
|
0.0 | [1..950] | [149..1099] |
|
|
0.0 | [1..950] | [1..950] |
|
|
0.0 | [1..950] | [1..951] |
|
|
0.0 | [1..950] | [65..1015] |
|
Region A: Residues: [1-497] |
1 11 21 31 41 51
| | | | | |
1 MGVPAFFRWL SRKYPSIIVN CVEEKPKECN GVKIPVDASK PNPNDVEFDN LYLDMNGIIH 60
61 PCTHPEDKPA PKNEDEMMVA IFEYIDRLFS IVRPRRLLYM AIDGVAPRAK MNQQRSRRFR 120
121 ASKEGMEAAV EKQRVREEIL AKGGFLPPEE IKERFDSNCI TPGTEFMDNL AKCLRYYIAD 180
181 RLNNDPGWKN LTVILSDASA PGEGEHKIMD YIRRQRAQPN HDPNTHHCLC GADADLIMLG 240
241 LATHEPNFTI IREEFKPNKP KPCGLCNQFG HEVKDCEGLP REKKGKHDEL ADSLPCAEGE 300
301 FIFLRLNVLR EYLERELTMA SLPFTFDVER SIDDWVFMCF FVGNDFLPHL PSLEIRENAI 360
361 DRLVNIYKNV VHKTGGYLTE SGYVNLQRVQ MIMLAVGEVE DSIFKKRKDD EDSFRRRQKE 420
421 KRKRMKRDQP AFTPSGILTP HALGSRNSPG SQVASNPRQA AYEMRMQNNS SPSISPNTSF 480
481 TSDGSPSPLG GIKRKAE
|
| Detection Method: |  |
| Confidence: | 1.21 |
| Match: | 1ul1X |
| Description: | Crystal structure of the human FEN1-PCNA complex |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| single-stranded DNA specific 3'-5' exodeoxyribonuclease activity | 3.71199179880106 | bayes_pls_golite062009 |
| exonuclease activity | 3.46607201774246 | bayes_pls_golite062009 |
| flap endonuclease activity | 3.35117165021395 | bayes_pls_golite062009 |
| endonuclease activity | 2.9231881727799 | bayes_pls_golite062009 |
| deoxyribonuclease activity | 2.73550697470983 | bayes_pls_golite062009 |
| endodeoxyribonuclease activity | 2.71246687883519 | bayes_pls_golite062009 |
| 5'-3' exonuclease activity | 2.50129811584994 | bayes_pls_golite062009 |
| nuclease activity | 2.49612885073648 | bayes_pls_golite062009 |
| exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters | 2.3119851698541 | bayes_pls_golite062009 |
| hydrolase activity | 2.24171130786956 | bayes_pls_golite062009 |
| ribonuclease activity | 2.17761411301039 | bayes_pls_golite062009 |
| hydrolase activity, acting on ester bonds | 2.11221521670814 | bayes_pls_golite062009 |
| nucleic acid binding | 2.0553491099036 | bayes_pls_golite062009 |
| DNA binding | 1.98330542087379 | bayes_pls_golite062009 |
| binding | 1.86375021779651 | bayes_pls_golite062009 |
| damaged DNA binding | 1.82833131243547 | bayes_pls_golite062009 |
| 5'-3' exodeoxyribonuclease activity | 1.59902329953921 | bayes_pls_golite062009 |
| structure-specific DNA binding | 1.57088273902548 | bayes_pls_golite062009 |
| exodeoxyribonuclease activity | 1.51267299365568 | bayes_pls_golite062009 |
| exodeoxyribonuclease activity, producing 5'-phosphomonoesters | 1.49423176639724 | bayes_pls_golite062009 |
| single-stranded DNA specific endodeoxyribonuclease activity | 1.47811426277519 | bayes_pls_golite062009 |
| double-stranded DNA specific exodeoxyribonuclease activity | 1.46817649825808 | bayes_pls_golite062009 |
| catalytic activity | 1.27951740231695 | bayes_pls_golite062009 |
| 5'-flap endonuclease activity | 1.13738790511505 | bayes_pls_golite062009 |
| single-stranded DNA specific exodeoxyribonuclease activity | 1.06918533266108 | bayes_pls_golite062009 |
| ribonuclease H activity | 0.943397169110632 | bayes_pls_golite062009 |
| double-stranded DNA binding | 0.550147498650064 | bayes_pls_golite062009 |
| single-stranded DNA specific 5'-3' exodeoxyribonuclease activity | 0.496731274592508 | bayes_pls_golite062009 |
| protein binding | 0.388252010955945 | bayes_pls_golite062009 |
| endodeoxyribonuclease activity, producing 5'-phosphomonoesters | 0.330551387282259 | bayes_pls_golite062009 |
| 3'-5' exonuclease activity | 0.175191448555725 | bayes_pls_golite062009 |
| endoribonuclease activity | 0.097472492148219 | bayes_pls_golite062009 |
| endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters | 0.0756835782024594 | bayes_pls_golite062009 |
|
Region A: Residues: [498-650] |
1 11 21 31 41 51
| | | | | |
1 DSDSEPEPED NVRLWEAGWK QRYYKNKFDV DAADEKFRRK VVQSYVEGLC WVLRYYYQGC 60
61 ASWKWYYPFH YAPFASDFEG IADMPSDFEK GTKPFKPLEQ LMGVFPAASG NFLPPSWRKL 120
121 MSDPDSSIID FYPEDFAIDL NGKKYAWQGV ALL
|
| Detection Method: | |
Shown below is our most confident prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [651-748] |
1 11 21 31 41 51
| | | | | |
1 PFVDERRLRA ALEEVYPDLT PEETRRNSLG GDVLFVGKHH PLHDFILELY QTGSTEPVEV 60
61 PPELCHGIQG KFSLDEEAIL PDQIVCSPVP MLRDLTQN
|
| Detection Method: | |
Shown below is our most confident prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [749-807] |
1 11 21 31 41 51
| | | | | |
1 TVVSINFKDP QFAEDYIFKA VMLPGARKPA AVLKPSDWEK SSNGRQWKPQ LGFNRDRRP
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [808-950] |
1 11 21 31 41 51
| | | | | |
1 VHLDQAAFRT LGHVMPRGSG TGIYSNAAPP PVTYQGNLYR PLLRGQAQIP KLMSNMRPQD 60
61 SWRGPPPLFQ QQRFDRGVGA EPLLPWNRML QTQNAAFQPN QYQMLAGPGG YPPRRDDRGG 120
121 RQGYPREGRK YPLPPPSGRY NWN
|
| Detection Method: | |
Shown below is our most confident prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
