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View Structure Prediction Details

Protein: NSFL1C
Organism: Homo sapiens
Length: 370 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NSFL1C.

Description E-value Query
Range
Subject
Range
NSF1C_RAT - NSFL1 cofactor p47 OS=Rattus norvegicus GN=Nsfl1c PE=1 SV=1
0.0 [1..370] [1..370]
NSF1C_MOUSE - NSFL1 cofactor p47 OS=Mus musculus GN=Nsfl1c PE=1 SV=1
0.0 [1..370] [1..370]
NSF1C_BOVIN - NSFL1 cofactor p47 OS=Bos taurus GN=NSFL1C PE=2 SV=1
0.0 [1..370] [1..370]
gi|193787565, gi... - gi|62898243|dbj|BAD97061.1| p47 protein isoform a variant [Homo sapiens], gi|5531827|gb|AAD44488.1| ...
0.0 [1..370] [1..370]
gi|109092584 - gi|109092584|ref|XP_001113343.1| PREDICTED: similar to p47 protein isoform a isoform 8 [Macaca mulat...
0.0 [1..370] [1..370]
gi|114680493 - gi|114680493|ref|XP_001154020.1| PREDICTED: p47 protein isoform 5 [Pan troglodytes]
0.0 [1..370] [1..372]

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Predicted Domain #1
Region A:
Residues: [1-68]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAERQEALR EFVAVTGAEE DRARFFLESA GWDLQIALAS FYEDGGDEDI VTISQATPSS  60
   61 VSRGTAPS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.757 0.063 nucleus a.60.12 DNA polymerase beta-like, second domain
View Download 0.672 0.001 Golgi apparatus a.144.2 Ribosomal protein L20
View Download 0.725 N/A N/A a.60.12 DNA polymerase beta-like, second domain
View Download 0.673 N/A N/A a.60.11 Hypothetical protein YjbJ
View Download 0.663 N/A N/A a.60.11 Hypothetical protein YjbJ

Predicted Domain #2
Region A:
Residues: [69-160]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DNRVTSFRDL IHDQDEDEEE EEGQRFYAGG SERSGQQIVG PPRKKSPNEL VDDLFKGAKE  60
   61 HGAVAVERVT KSPGETSKPR PFAGGGYRLG AA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.371 a.4.5 "Winged helix" DNA-binding domain
View Download 0.278 c.51.1 Anticodon-binding domain of Class II aaRS
View Download 0.264 a.24.15 FAD-dependent thiol oxidase
View Download 0.257 a.109.1 Class II MHC-associated invariant chain ectoplasmic trimerization domain
View Download 0.262 d.58.43 Mechanosensitive channel protein MscS (YggB), C-terminal domain

Predicted Domain #3
Region A:
Residues: [161-271]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PEEESAYVAG EKRQHSSQDV HVVLKLWKSG FSLDNGELRS YQDPSNAQFL ESIRRGEVPA  60
   61 ELRRLAHGGQ VNLDMEDHRD EDFVKPKGAF KAFTGEGQKL GSTAPQVLST S

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 20.69897
Match: 1ss6A
Description: Solution structure of SEP domain from human p47
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [272-370]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPAQQAENEA KASSSILIDE SEPTTNIQIR LADGGRLVQK FNHSHRISDI RLFIVDARPA  60
   61 MAATSFILMT TFPNKELADE SQTLKEANLL NAVIVQRLT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 35.69897
Match: 1s3sG
Description: Crystal structure of AAA ATPase p97/VCP ND1 in complex with p47 C
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.73741203922834 bayes_pls_golite062009
protein binding 1.6357717410164 bayes_pls_golite062009
small conjugating protein ligase activity 1.16524840930815 bayes_pls_golite062009
ubiquitin-protein ligase activity 0.544811416739 bayes_pls_golite062009
acid-amino acid ligase activity 0.288560953468985 bayes_pls_golite062009
hydrolase activity 0.0740461973842489 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle