YRC Public Data Repository - Protein Structure Prediction

Protein:	NUDT15
Organism:	Homo sapiens
Length:	164 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NUDT15.

Description	E-value	Query Range	Subject Range
gi\|149049947, gi... - gi\|27701910\|ref\|XP_214236.1\| PREDICTED: similar to MTH2 protein [Rattus norvegicus], gi\|157823211\|re...	5.0E-26	[3..164]	[2..163]
gi\|106892416, gi... - gi\|148654328\|ref\|YP_001274533.1\| NUDIX hydrolase [Roseiflexus sp. RS-1], gi\|148566438\|gb\|ABQ88583.1\|...	4.0E-25	[6..156]	[14..160]
gi\|94366446, gi\|... - gi\|94368225\|ref\|XP_994694.1\| PREDICTED: similar to MTH2 protein [Mus musculus], gi\|94366446\|ref\|XP_9...	4.0E-25	[21..164]	[20..163]
gi\|113942320, gi... - gi\|113942320\|ref\|ZP_01428055.1\| NUDIX hydrolase [Herpetosiphon aurantiacus ATCC 23779], gi\|113896038...	6.0E-25	[9..156]	[8..151]
ADPP_METJA - ADP-ribose pyrophosphatase OS=Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / ... ADPP_METJA - ADP-ribose pyrophosphatase OS=Methanocaldococcus jannaschii GN=nudF PE=1 SV=1	2.0E-24	[7..148]	[36..166]
gi\|40555862 - gi\|40555862\|gb\|AAH64607.1\| NUDT15 protein [Homo sapiens]	3.0E-24	[29..164]	[28..163]
gi\|30314626 - gi\|30314626\|dbj\|BAC76070.1\| Nudix hydrolase [Synechococcus sp. PCC 7002]	6.0E-24	[1..155]	[1..149]

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Predicted Domain #1

Region A:
Residues: [1-164]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTASAQPRGR RPGVGVGVVV TSCKHPRCVL LGKRKGSVGA GSFQLPGGHL EFGETWEECA  60
   61 QRETWEEAAL HLKNVHFASV VNSFIEKENY HYVTILMKGE VDVTHDSEPK NVEPEKNESW 120
  121 EWVPWEELPP LDQLFWGLRC LKEQGYDPFK EDLNHLVGYK GNHL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	21.0
Match:	2fmlA
Description:	Crystal structure of MutT/nudix family protein from Enterococcus faecalis
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	0.960699420760702	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: