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View Structure Prediction Details

Protein: UNC119
Organism: Homo sapiens
Length: 240 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for UNC119.

Description E-value Query
Range
Subject
Range
U119A_RAT - Protein unc-119 homolog A OS=Rattus norvegicus GN=Unc119 PE=1 SV=1
0.0 [1..240] [1..240]
U119A_MOUSE - Protein unc-119 homolog A OS=Mus musculus GN=Unc119 PE=1 SV=1
0.0 [1..240] [1..240]
gi|114668508 - gi|114668508|ref|XP_001145903.1| PREDICTED: similar to retinal protein isoform 2 [Pan troglodytes]
3.0E-99 [1..240] [1..240]
U119A_BOVIN - Protein unc-119 homolog A OS=Bos taurus GN=UNC119 PE=2 SV=1
1.0E-94 [1..240] [1..240]
gi|57091859 - gi|57091859|ref|XP_548289.1| PREDICTED: similar to Unc-119 protein homolog (Retinal protein 4) (HRG4...
1.0E-93 [1..240] [1..242]

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Predicted Domain #1
Region A:
Residues: [1-81]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKVKKGGGGA GTATESAPGP SGQSVAPIPQ PPAESESGSE SEPDAGPGPR PGPLQRKQPI  60
   61 GPEDVLGLQR ITGDYLCSPE E

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [82-240]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NIYKIDFVRF KIRDMDSGTV LFEIKKPPVS ERLPINRRDL DPNAGRFVRY QFTPAFLRLR  60
   61 QVGATVEFTV GDKPVNNFRM IERHYFRNQL LKSFDFHFGF CIPSSKNTCE HIYDFPPLSE 120
  121 ELISEMIRHP YETQSDSFYF VDDRLVMHNK ADYSYSGTP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 47.39794
Match: 1ksgB
Description: GMP-PDE delta
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.01555579124143 bayes_pls_golite062009
ligand-gated channel activity 1.5302582659987 bayes_pls_golite062009
ligand-gated ion channel activity 1.5302582659987 bayes_pls_golite062009
protein binding 1.50286160643298 bayes_pls_golite062009
gated channel activity 1.42896395862304 bayes_pls_golite062009
cation channel activity 1.4256218398774 bayes_pls_golite062009
ion channel activity 1.40005559320777 bayes_pls_golite062009
substrate-specific channel activity 1.36653752383074 bayes_pls_golite062009
channel activity 1.35767020846709 bayes_pls_golite062009
passive transmembrane transporter activity 1.35767020846709 bayes_pls_golite062009
metarhodopsin binding 0.869827712400021 bayes_pls_golite062009
voltage-gated cation channel activity 0.855931938850398 bayes_pls_golite062009
opsin binding 0.839214663991459 bayes_pls_golite062009
voltage-gated ion channel activity 0.789955030733139 bayes_pls_golite062009
voltage-gated channel activity 0.780717736949525 bayes_pls_golite062009
potassium channel activity 0.559325988586613 bayes_pls_golite062009
metal ion transmembrane transporter activity 0.521778252711535 bayes_pls_golite062009
voltage-gated potassium channel activity 0.512152861387956 bayes_pls_golite062009
inward rectifier potassium channel activity 0.0912506266585198 bayes_pls_golite062009
cytoskeletal protein binding 0.0605091734844516 bayes_pls_golite062009

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