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View Structure Prediction Details

Protein: TPK1
Organism: Homo sapiens
Length: 243 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TPK1.

Description E-value Query
Range
Subject
Range
gi|46250253 - gi|46250253|gb|AAH68460.1| Thiamin pyrophosphokinase 1 [Homo sapiens]
8.0E-91 [1..243] [1..243]
gi|114616588 - gi|114616588|ref|XP_519461.2| PREDICTED: thiamin pyrophosphokinase 1 [Pan troglodytes]
1.0E-90 [1..243] [1..243]
gi|83755026, gi|... - gi|83755027|pdb|2F17|B Chain B, Mouse Thiamin Pyrophosphokinase In A Ternary Complex With Pyrithiami...
6.0E-90 [1..243] [21..263]
TPK1_BOVIN - Thiamin pyrophosphokinase 1 OS=Bos taurus GN=TPK1 PE=2 SV=1
6.0E-83 [1..243] [1..243]
gi|109473428 - gi|109473428|ref|XP_001073146.1| PREDICTED: similar to Thiamin pyrophosphokinase 1 (Thiamine pyropho...
4.0E-78 [7..242] [47..285]
gi|109068707 - gi|109068707|ref|XP_001094591.1| PREDICTED: similar to thiamin pyrophosphokinase 1 [Macaca mulatta]
2.0E-75 [33..243] [117..327]
TPK1_ORYSJ - Thiamine pyrophosphokinase 1 OS=Oryza sativa subsp. japonica GN=TPK1 PE=2 SV=1
8.0E-73 [4..243] [18..264]

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Predicted Domain #1
Region A:
Residues: [1-243]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEHAFTPLEP LLSTGNLKYC LVILNQPLDN YFRHLWNKAL LRACADGGAN RLYDITEGER  60
   61 ESFLPEFING DFDSIRPEVR EYYATKGCEL ISTPDQDHTD FTKCLKMLQK KIEEKDLKVD 120
  121 VIVTLGGLAG RFDQIMASVN TLFQATHITP FPIIIIQEES LIYLLQPGKH RLHVDTGMEG 180
  181 DWCGLIPVGQ PCMQVTTTGL KWNLTNDVLA FGTLVSTSNT YDGSGVVTVE TDHPLLWTMA 240
  241 IKS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 91.39794
Match: 1ig3A
Description: Thiamin pyrophosphokinase, substrate-binding domain; Thiamin pyrophosphokinase, catalytic domain
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle