YRC Public Data Repository - Protein Structure Prediction

Protein:	UNG
Organism:	Homo sapiens
Length:	313 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for UNG.

Description	E-value	Query Range	Subject Range
gi\|109098647 - gi\|109098647\|ref\|XP_001104341.1\| PREDICTED: similar to uracil-DNA glycosylase isoform UNG2 isoform 1...	0.0	[1..313]	[1..313]
UNG_MOUSE - Uracil-DNA glycosylase OS=Mus musculus GN=Ung PE=2 SV=2	0.0	[1..313]	[1..306]
gi\|45383742, gi\|... - gi\|45383742\|ref\|NP_989520.1\| uracil-DNA glycosylase [Gallus gallus], gi\|24571183\|gb\|AAN62908.1\| urac...	0.0	[1..313]	[1..299]
gi\|7413914 - gi\|7413914\|emb\|CAB85708.1\| uracil-DNA glycosylase [Gadus morhua]	0.0	[1..313]	[1..301]
gi\|28279160, gi\|... - gi\|41055778\|ref\|NP_957268.1\| uracil-DNA glycosylase [Danio rerio], gi\|28279160\|gb\|AAH45912.1\| Uracil...	0.0	[1..313]	[1..291]
gi\|61365565, gi\|... - gi\|61365565\|gb\|AAX42728.1\| uracil-DNA glycosylase [synthetic construct], gi\|54696150\|gb\|AAV38447.1\| ...	0.0	[44..313]	[35..304]
gi\|280876, gi\|11... - gi\|6224979\|ref\|NP_003353.1\| uracil-DNA glycosylase isoform UNG1 precursor [Homo sapiens], gi\|37599\|e... gi\|254071525, gi... - gi\|254071527\|gb\|ACT64523.1\| uracil-DNA glycosylase protein [synthetic construct], gi\|254071525\|gb\|AC...	0.0	[44..313]	[35..304]
gi\|114646826 - gi\|114646826\|ref\|XP_001136198.1\| PREDICTED: hypothetical protein isoform 1 [Pan troglodytes]	0.0	[44..313]	[35..304]

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Predicted Domain #1

Region A:
Residues: [1-91]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIGQKTLYSF FSPSPARKRH APSPEPAVQG TGVAGVPEES GDAAAIPAKK APAGQEEPGT  60
   61 PPSSPLSAEQ LDRIQRNKAA ALLRLAARNV P

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.247	0.410	uracil DNA N-glycosylase activity	a.39.1	EF-hand
View	Download	0.315	0.032	uracil DNA N-glycosylase activity	a.24.13	Domain of the SRP/SRP receptor G-proteins
View	Download	0.271	N/A	N/A	a.64.2	Bacteriocin AS-48
View	Download	0.271	N/A	N/A	a.24.13	Domain of the SRP/SRP receptor G-proteins
View	Download	0.238	N/A	N/A	a.179.1	Replisome organizer (g39p helicase loader/inhibitor protein)

Predicted Domain #2

Region A:
Residues: [92-313]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VGFGESWKKH LSGEFGKPYF IKLMGFVAEE RKHYTVYPPP HQVFTWTQMC DIKDVKVVIL  60
   61 GQDPYHGPNQ AHGLCFSVQR PVPPPPSLEN IYKELSTDIE DFVHPGHGDL SGWAKQGVLL 120
  121 LNAVLTVRAH QANSHKERGW EQFTDAVVSW LNQNSNGLVF LLWGSYAQKK GSAIDRKRHH 180
  181 VLQTAHPSPL SVYRGFFGCR HFSKTNELLQ KSGKKPIDWK EL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	106.0
Match:	1yuoA
Description:	Optimisation of the surface electrostatics as a strategy for cold adaptation of uracil-DNA N-glycosylase (UNG)from atlantic cod (Gadus morhua)
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits