YRC Public Data Repository - Protein Structure Prediction

Protein:	TIFA
Organism:	Homo sapiens
Length:	184 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TIFA.

Description	E-value	Query Range	Subject Range
gi\|33086586 - gi\|33086586\|gb\|AAP92605.1\| Ab2-389 [Rattus norvegicus]	8.0E-88	[1..178]	[241..419]
gi\|55623106 - gi\|55623106\|ref\|XP_526660.1\| PREDICTED: TRAF-interacting protein with a forkhead-associated domain [...	2.0E-84	[1..184]	[1..184]
TIFA_MOUSE - TRAF-interacting protein with FHA domain-containing protein A OS=Mus musculus GN=Tifa PE=1 SV=1	1.0E-83	[1..183]	[1..183]
gi\|109075389 - gi\|109075389\|ref\|XP_001092116.1\| PREDICTED: similar to TRAF-interacting protein with a forkhead-asso...	3.0E-82	[1..184]	[1..185]
gi\|74002374 - gi\|74002374\|ref\|XP_545028.2\| PREDICTED: similar to TRAF-interacting protein with a forkhead-associat...	5.0E-81	[1..183]	[24..207]
gi\|42718028 - gi\|42718028\|gb\|AAQ74975.2\| TRAF2-binding protein [Ctenopharyngodon idella]	1.0E-57	[1..165]	[1..168]
gi\|113416772 - gi\|113416772\|ref\|XP_933560.2\| PREDICTED: hypothetical protein [Homo sapiens]	4.0E-57	[10..149]	[311..446]

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Predicted Domain #1

Region A:
Residues: [1-184]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSFEDADTE ETVTCLQMTV YHPGQLQCGI FQSISFNREK LPSSEVVKFG RNSNICHYTF  60
   61 QDKQVSRVQF SLQLFKKFNS SVLSFEIKNM SKKTNLIVDS RELGYLNKMD LPYRCMVRFG 120
  121 EYQFLMEKED GESLEFFETQ FILSPRSLLQ ENNWPPHRPI PEYGTYSLCS SQSSSPTEMD 180
  181 ENES

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Detection Method:	FFAS03
Confidence:	1.37
Match:	1mzkA
Description:	NMR structure of kinase-interacting FHA domain of kinase associated protein phosphatase, KAPP in Arabidopsis
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	2.5899381751105	bayes_pls_golite062009
receptor signaling protein activity	1.9561625448916	bayes_pls_golite062009
protein binding	1.9481173032755	bayes_pls_golite062009
signal transducer activity	1.01675970359647	bayes_pls_golite062009
molecular transducer activity	1.01675970359647	bayes_pls_golite062009
transforming growth factor beta receptor, cytoplasmic mediator activity	0.100003424709245	bayes_pls_golite062009
transcription regulator activity	0.0844693383782284	bayes_pls_golite062009
DNA binding	0.0766861334337203	bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase signaling protein activity	0.00405234232048407	bayes_pls_golite062009
nucleic acid binding	0.00137859950302552	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: