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View Structure Prediction Details

Protein: LGTN
Organism: Homo sapiens
Length: 584 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LGTN.

Description E-value Query
Range
Subject
Range
gi|114572164 - gi|114572164|ref|XP_514150.2| PREDICTED: ligatin [Pan troglodytes]
0.0 [1..584] [100..683]
EIF2D_PONAB - Eukaryotic translation initiation factor 2D OS=Pongo abelii GN=EIF2D PE=2 SV=1
LIGA_PONPY - Ligatin - Pongo pygmaeus (Orangutan)
0.0 [1..584] [1..584]
LGTN - ligatin
0.0 [1..584] [1..584]
gi|109018597 - gi|109018597|ref|XP_001086830.1| PREDICTED: similar to ligatin isoform 4 [Macaca mulatta]
0.0 [1..584] [1..584]
EIF2D_MOUSE - Eukaryotic translation initiation factor 2D OS=Mus musculus GN=Eif2d PE=1 SV=3
0.0 [1..583] [1..570]

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Predicted Domain #1
Region A:
Residues: [1-180]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFAKAFRVKS NTAIKGSDRR KLRADVTTAF PTLGTDQVSE LVPGKEELNI VKLYAHKGDA  60
   61 VTVYVSGGNP ILFELEKNLY PTVYTLWSYP DLLPTFTTWP LVLEKLVGGA DLMLPGLVMP 120
  121 PAGLPQVQKG DLCAISLVGN RAPVAIGVAA MSTAEMLTSG LKGRGFSVLH TYQDHLWRSG 180
  181 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 40.39794
Match: 2ausC
Description: No description for 2ausC was found.

Predicted Domain #2
Region A:
Residues: [181-248]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NKSSPPSIAP LALDSADLSE EKGSVQMDST LQGDMRHMTL EGEEENGEVH QAREDKSLSE  60
   61 APEDTSTR

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [249-358]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GLNQDSTDSK TLQEQMDELL QQCFLHALKC RVKKADLPLL TSTFLGSHMF SCCPEGRQLD  60
   61 IKKSSYKKLS KFLQQMQQEQ IIQVKELSKG VESIVAVDWK HPRITSFVIP 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.258 c.47.1 Thioredoxin-like
View Download 0.236 d.52.7 Ribosome-binding factor A, RbfA

Predicted Domain #4
Region A:
Residues: [359-468]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EPSPTSQTIQ EGSREQPYHP PDIKPLYCVP ASMTLLFQES GHKKGSFLEG SEVRTIVINY  60
   61 AKKNDLVDAD NKNLVRLDPI LCDCILEKNE QHTVMKLPWD SLLTRCLEKL 

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.32
Match: 1v32A
Description: Solution structure of the SWIB/MDM2 domain of the hypothetical protein At5g08430 from Arabidopsis thaliana
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
structural molecule activity 4.72233209840291 bayes_pls_golite062009
protein binding 2.52181725362933 bayes_pls_golite062009
binding 2.18328191469694 bayes_pls_golite062009
transcription regulator activity 1.77240364924631 bayes_pls_golite062009
transcription activator activity 0.995535823852062 bayes_pls_golite062009
transcription repressor activity 0.464336112087611 bayes_pls_golite062009
basal transcription repressor activity 0.307849920263354 bayes_pls_golite062009
transcription factor binding 0.203735997461782 bayes_pls_golite062009
catalytic activity 0.151165614150825 bayes_pls_golite062009
transcription cofactor activity 0.125030292437611 bayes_pls_golite062009
transcription coactivator activity 0.012901717642134 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [469-584]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QPAYQVTLPG QEPIVKKGRI CPIDITLAQR ASNKKVTVVR NLEAYGLDPY SVAAILQQRC  60
   61 QASTTVNPAP GAKDSLQVQI QGNQVHHLGW LLLEEYQLPR KHIQGLEKAL KPGKKK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 30.39794
Match: 2if1A
Description: HUMAN TRANSLATION INITIATION FACTOR EIF1, NMR, 29 STRUCTURES
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
translation initiation factor activity 6.56930940751046 bayes_pls_golite062009
translation regulator activity 2.27579767245564 bayes_pls_golite062009
translation factor activity, nucleic acid binding 2.25914933413253 bayes_pls_golite062009
binding 1.99916637558859 bayes_pls_golite062009
nucleic acid binding 1.69119554284364 bayes_pls_golite062009
protein binding 1.47118967208188 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle