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View Structure Prediction Details

Protein: FOXO3
Organism: Homo sapiens
Length: 673 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FOXO3.

Description E-value Query
Range
Subject
Range
gi|183396873, gi... - gi|183396873|gb|AAI66015.1| Forkhead box O3 [synthetic construct], gi|117616362|gb|ABK42199.1| Fkhr2...
FOXO3_MOUSE - Forkhead box protein O3 OS=Mus musculus GN=Foxo3 PE=1 SV=1
338.0 [0..1] [673..1]
gi|60654355 - gi|60654355|gb|AAX29868.1| forkhead box O3A [synthetic construct]
326.0 [0..1] [673..1]
gi|149046963, gi... - gi|34852910|ref|XP_215421.2| PREDICTED: similar to forkhead box O3a [Rattus norvegicus], gi|15782273...
322.0 [0..1] [673..1]
gi|109073113 - gi|109073113|ref|XP_001093593.1| PREDICTED: similar to forkhead box O3A [Macaca mulatta]
321.0 [0..1] [673..1]
gi|76631009 - gi|76631009|ref|XP_615634.2| PREDICTED: forkhead box O3 [Bos taurus]
313.0 [0..1] [673..1]
gi|54261669 - gi|54261669|gb|AAH84603.1| Unknown (protein for MGC:98855) [Xenopus laevis]
285.0 [0..3] [673..1]
gi|73973695 - gi|73973695|ref|XP_539075.2| PREDICTED: similar to forkhead box O3A isoform 1 [Canis familiaris]
255.0 [0..207] [673..28]
gi|114651578 - gi|114651578|ref|XP_522749.2| PREDICTED: forkhead box O1A [Pan troglodytes]
244.0 [0..8] [673..174]
FOXO1 - forkhead box O1
244.0 [0..9] [673..1]

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Predicted Domain #1
Region A:
Residues: [1-95]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAEAPASPAP LSPLEVELDP EFEPQSRPRS CTWPLQRPEL QASPAKPSGE TAADSMIPEE  60
   61 EDDEDDEDGG GRAGSAMAIG GGGGSGTLGS GLLLE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [96-269]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DSARVLAPGG QDPGSGPATA AGGLSGGTQA LLQPQQPLPP PQPGAAGGSG QPRKCSSRRN  60
   61 AWGNLSYADL ITRAIESSPD KRLTLSQIYE WMVRCVPYFK DKGDSNSSAG WKNSIRHNLS 120
  121 LHSRFMRVQN EGTGKSSWWI INPDGGKSGK APRRRAVSMD NSNKYTKSRG RAAK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 23.0
Match: 1e17A
Description: Afx (Foxo4)
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [270-542]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KKAALQTAPE SADDSPSQLS KWPGSPTSRS SDELDAWTDF RSRTNSNAST VSGRLSPIMA  60
   61 STELDEVQDD DAPLSPMLYS SSASLSPSVS KPCTVELPRL TDMAGTMNLN DGLTENLMDD 120
  121 LLDNITLPPS QPSPTGGLMQ RSSSFPYTTK GSGLGSPTSS FNSTVFGPSS LNSLRQSPMQ 180
  181 TIQENKPATF SSMSHYGNQT LQDLLTSDSL SHSDVMMTQS DPLMSQASTA VSAQNSRRNV 240
  241 MLRNDPMMSF AAQPNQGSLV NQNLLHHQHQ TQG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [543-673]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ALGGSRALSN SVSNMGLSES SSLGSAKHQQ QSPVSQSMQT LSDSLSGSSL YSTSANLPVM  60
   61 GHEKFPSDLD LDMFNGSLEC DMESIIRSEL MDADGLDFNF DSLISTQNVV GLNVGNFTGA 120
  121 KQASSQSWVP G

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.518 N/A N/A a.8.3 Families 57/38 glycoside transferase middle domain
View Download 0.361 N/A N/A a.73.1 Retrovirus capsid protein, N-terminal core domain
View Download 0.345 N/A N/A d.16.1 FAD-linked reductases, C-terminal domain
View Download 0.316 N/A N/A d.20.1 UBC-like
View Download 0.310 N/A N/A a.118.1 ARM repeat
View Download 0.305 N/A N/A a.118.9 ENTH/VHS domain


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