YRC Public Data Repository - Protein Structure Prediction

Protein:	NGLY1
Organism:	Homo sapiens
Length:	654 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NGLY1.

Description	E-value	Query Range	Subject Range
NGLY1_MACFA - Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase OS=Macaca fascicularis GN=NGLY1 PE=2 SV=...	0.0	[19..654]	[19..654]
gi\|109052533 - gi\|109052533\|ref\|XP_001093251.1\| PREDICTED: similar to N-glycanase 1 isoform 4 [Macaca mulatta]	0.0	[19..654]	[19..654]
gi\|8347622, gi\|1... - gi\|8347622\|gb\|AAF74723.1\|AF250927_1 PNGase [Mus musculus], gi\|30517852\|gb\|AAP03060.1\| peptide N-glyc...	0.0	[19..654]	[19..651]
NGLY1_RAT - Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase OS=Rattus norvegicus GN=Ngly1 PE=2 SV=2	0.0	[19..654]	[19..651]
gi\|76656037 - gi\|76656037\|ref\|XP_613238.2\| PREDICTED: similar to N-glycanase 1 [Bos taurus]	0.0	[3..654]	[113..766]
gi\|12654285 - gi\|12654285\|gb\|AAH00963.1\|AAH00963 Similar to peptide N-glycanase homolog (S.cerevisiae) [Homo sapie...	0.0	[19..654]	[16..633]
gi\|114586207 - gi\|114586207\|ref\|XP_516333.2\| PREDICTED: hypothetical protein [Pan troglodytes]	0.0	[19..654]	[218..835]

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Predicted Domain #1

Region A:
Residues: [1-109]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAAALGSSS GSASPAVAEL CQNTPETFLE ASKLLLTYAD NILRNPNDEK YRSIRIGNTA  60
   61 FSTRLLPVRG AVECLFEMGF EEGETHLIFP KKASVEQLQK IRDLIAIER

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	30.69897
Match:	2ccqA
Description:	No description for 2ccqA was found.

Predicted Domain #2

Region A:
Residues: [110-458]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSRLDGSNKS HKVKSSQQPA ASTQLPTTPS SNPSGLNQHT RNRQGQSSDP PSASTVAADS  60
   61 AILEVLQSNI QHVLVYENPA LQEKALACIP VQELKRKSQE KLSRARKLDK GINISDEDFL 120
  121 LLELLHWFKE EFFHWVNNVL CSKCGGQTRS RDRSLLPSDD ELKWGAKEVE DHYCDACQFS 180
  181 NRFPRYNNPE KLLETRCGRC GEWANCFTLC CRAVGFEARY VWDYTDHVWT EVYSPSQQRW 240
  241 LHCDACEDVC DKPLLYEIGW GKKLSYVIAF SKDEVVDVTW RYSCKHEEVI ARRTKVKEAL 300
  301 LRDTINGLNK QRQLFLSENR RKELLQRIIV ELVEFISPKT PKPGELGGR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	98.0
Match:	2f4mA
Description:	The Mouse PNGase-HR23 Complex Reveals a Complete Remodulation of the Protein-Protein Interface Compared to its Yeast Orthologs
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [459-654]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ISGSVAWRVA RGEMGLQRKE TLFIPCENEK ISKQLHLCYN IVKDRYVRVS NNNQTISGWE  60
   61 NGVWKMESIF RKVETDWHMV YLARKEGSSF AYISWKFECG SVGLKVDSIS IRTSSQTFQT 120
  121 GTVEWKLRSD TAQVELTGDN SLHSYADFSG ATEVILEAEL SRGDGDVAWQ HTQLFRQSLN 180
  181 DHEENCLEII IKFSDL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	67.69897
Match:	2g9gA
Description:	No description for 2g9gA was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits