YRC Public Data Repository - Protein Structure Prediction

Protein:	METTL3
Organism:	Homo sapiens
Length:	580 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for METTL3.

Description	E-value	Query Range	Subject Range
gi\|30353931 - gi\|30353931\|gb\|AAH52244.1\| Methyltransferase like 3 [Homo sapiens]	0.0	[1..580]	[1..580]
gi\|114651891 - gi\|114651891\|ref\|XP_001154543.1\| PREDICTED: methyltransferase like 3 isoform 2 [Pan troglodytes]	0.0	[1..580]	[1..592]
gi\|109082747 - gi\|109082747\|ref\|XP_001097947.1\| PREDICTED: similar to methyltransferase like 3 isoform 2 [Macaca mu...	0.0	[1..580]	[1..580]
gi\|77627973, gi\|... - gi\|77627973\|ref\|NP_062695.2\| methyltransferase-like 3 [Mus musculus], gi\|26351497\|dbj\|BAC39385.1\| un...	0.0	[1..580]	[1..580]
gi\|73977380 - gi\|73977380\|ref\|XP_532627.2\| PREDICTED: similar to methyltransferase like 3 isoform 1 [Canis familia...	0.0	[1..580]	[1..580]
gi\|67078430, gi\|... - gi\|67078430\|ref\|NP_001019965.1\| methyltransferase-like 3 [Rattus norvegicus], gi\|66910595\|gb\|AAH9740...	0.0	[1..580]	[1..580]

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Predicted Domain #1

Region A:
Residues: [1-141]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDTWSSIQA HKKQLDSLRE RLQRRRKQDS GHLDLRNPEA ALSPTFRSDS PVPTAPTSGG  60
   61 PKPSTASAVP ELATDPELEK KLLHHLSDLA LTLPTDAVSI CLAISTPDAP ATQDGVESLL 120
  121 QKFAAQELIE VKRGLLQDDA H

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [142-231]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PTLVTYADHS KLSAMMGAVA EKKGPGEVAG TVTGQKRRAE QDSTTVAAFA SSLVSGLNSS  60
   61 ASEPAKEPAK KSRKHAASDV DLEIESLLNQ

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [232-363]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QSTKEQQSKK VSQEILELLN TTTAKEQSIV EKFRSRGRAQ VQEFCDYGTK EECMKASDAD  60
   61 RPCRKLHFRR IINKHTDESL GDCSFLNTCF HMDTCKYVHY EIDACMDSEA PGSKDHTPSQ 120
  121 ELALTQSVGG DS

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.219	0.184	transferase activity	a.45.1	Glutathione S-transferase (GST), C-terminal domain

Predicted Domain #4

Region A:
Residues: [364-580]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SADRLFPPQW ICCDIRYLDV SILGKFAVVM ADPPWDIHME LPYGTLTDDE MRRLNIPVLQ  60
   61 DDGFLFLWVT GRAMELGREC LNLWGYERVD EIIWVKTNQL QRIIRTGRTG HWLNHGKEHC 120
  121 LVGVKGNPQG FNQGLDCDVI VAEVRSTSHK PDEIYGMIER LSPGTRKIEL FGRPHNVQPN 180
  181 WITLGNQLDG IHLLDPDVVA RFKQRYPDGI ISKPKNL

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.04
Match:	1g60A
Description:	Methyltransferase mboII
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
methyltransferase activity	3.68431317301075	bayes_pls_golite062009
N-methyltransferase activity	3.64494850793256	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	3.60853685152199	bayes_pls_golite062009
protein methyltransferase activity	3.51986359093355	bayes_pls_golite062009
DNA-methyltransferase activity	3.47923436720314	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	2.91374296950366	bayes_pls_golite062009
histone methyltransferase activity	2.666651371662	bayes_pls_golite062009
RNA methyltransferase activity	2.63941856307703	bayes_pls_golite062009
protein-arginine N-methyltransferase activity	1.99340565364513	bayes_pls_golite062009
arginine N-methyltransferase activity	1.99340565364513	bayes_pls_golite062009
transferase activity	1.97261773840408	bayes_pls_golite062009
rRNA methyltransferase activity	1.85380504590369	bayes_pls_golite062009
binding	1.65046086869658	bayes_pls_golite062009
histone-arginine N-methyltransferase activity	1.64765900536818	bayes_pls_golite062009
transcription regulator activity	1.59599828300594	bayes_pls_golite062009
site-specific DNA-methyltransferase (adenine-specific) activity	1.5743030926483	bayes_pls_golite062009
DNA binding	1.48691268044769	bayes_pls_golite062009
tRNA methyltransferase activity	1.38914410921124	bayes_pls_golite062009
nucleic acid binding	1.36595590938226	bayes_pls_golite062009
protein-arginine omega-N monomethyltransferase activity	1.27753381141602	bayes_pls_golite062009
DNA (cytosine-5-)-methyltransferase activity	1.23915163423518	bayes_pls_golite062009
catalytic activity	1.16970557486814	bayes_pls_golite062009
RNA binding	1.10288658549985	bayes_pls_golite062009
protein-arginine omega-N symmetric methyltransferase activity	0.862671287243863	bayes_pls_golite062009
rRNA (uridine) methyltransferase activity	0.837734735695963	bayes_pls_golite062009
histone methyltransferase activity (H4-R3 specific)	0.735680462496249	bayes_pls_golite062009
protein-arginine omega-N asymmetric methyltransferase activity	0.51222176401398	bayes_pls_golite062009
tRNA (cytosine)-methyltransferase activity	0.325961687103877	bayes_pls_golite062009
tRNA (cytosine-5-)-methyltransferase activity	0.325961687103877	bayes_pls_golite062009
histone binding	0.230289474831554	bayes_pls_golite062009
rRNA (adenine) methyltransferase activity	0.113328595762489	bayes_pls_golite062009
rRNA (adenine-N6,N6-)-dimethyltransferase activity	0.0390774859535424	bayes_pls_golite062009
mRNA methyltransferase activity	0.03091406523028	bayes_pls_golite062009
mRNA (guanine-N7-)-methyltransferase activity	0.03091406523028	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: