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View Structure Prediction Details

Protein: RFX3
Organism: Homo sapiens
Length: 749 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RFX3.

Description E-value Query
Range
Subject
Range
gi|73946688 - gi|73946688|ref|XP_533540.2| PREDICTED: similar to regulatory factor X3 isoform b isoform 1 [Canis f...
0.0 [1..749] [1..749]
RFX3_MACFA - Transcription factor RFX3 OS=Macaca fascicularis GN=RFX3 PE=2 SV=1
0.0 [1..749] [1..749]
gi|109111667 - gi|109111667|ref|XP_001086729.1| PREDICTED: similar to regulatory factor X3 isoform b isoform 6 [Mac...
0.0 [1..749] [1..749]
RFX3_MOUSE - Transcription factor RFX3 OS=Mus musculus GN=Rfx3 PE=1 SV=2
0.0 [1..749] [1..749]
gi|114623632 - gi|114623632|ref|XP_001136158.1| PREDICTED: regulatory factor X3 isoform 4 [Pan troglodytes]
0.0 [1..749] [1..749]

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Predicted Domain #1
Region A:
Residues: [1-168]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQTSETGSDT GSTVTLQTSV ASQAAVPTQV VQQVPVQQQV QQVQTVQQVQ HVYPAQVQYV  60
   61 EGSDTVYTNG AIRTTTYPYT ETQMYSQNTG GNYFDTQGSS AQVTTVVSSH SMVGTGGIQM 120
  121 GVTGGQLISS SGGTYLIGNS MENSGHSVTH TTRASPATIE MAIETLQK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.522879
Match: 1m2vB
Description: Sec24
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [169-258]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SDGLSTHRSS LLNSHLQWLL DNYETAEGVS LPRSTLYNHY LRHCQEHKLD PVNAASFGKL  60
   61 IRSIFMGLRT RRLGTRGNSK YHYYGIRVKP 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 33.221849
Match: 1dp7P
Description: Class II MHC transcription factor RFX1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.55329976718261 bayes_pls_golite062009
DNA binding 5.08959163553491 bayes_pls_golite062009
nucleic acid binding 4.69183445184264 bayes_pls_golite062009
transcription factor activity 4.33152142980289 bayes_pls_golite062009
transcription repressor activity 3.85678231380989 bayes_pls_golite062009
binding 3.52874320222492 bayes_pls_golite062009
sequence-specific DNA binding 2.48053910222825 bayes_pls_golite062009
transcription activator activity 2.37668609508629 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.70025468248325 bayes_pls_golite062009
specific transcriptional repressor activity 0.96257232341735 bayes_pls_golite062009
transcription factor binding 0.85714789329232 bayes_pls_golite062009
protein binding 0.753698599635855 bayes_pls_golite062009
transcription corepressor activity 0.322180400748724 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.0856082199488197 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [259-322]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DSPLNRLQED MQYMAMRQQP MQQKQRYKPM QKVDGVADGF TGSGQQTGTS VEQTVIAQSQ  60
   61 HHQQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [323-514]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FLDASRALPE FGEVEISSLP DGTTFEDIKS LQSLYREHCE AILDVVVNLQ FSLIEKLWQT  60
   61 FWRYSPSTPT DGTTITESSN LSEIESRLPK AKLITLCKHE SILKWMCNCD HGMYQALVEI 120
  121 LIPDVLRPIP SALTQAIRNF AKSLEGWLSN AMNNIPQRMI QTKVAAVSAF AQTLRRYTSL 180
  181 NHLAQAARAV LQ

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [515-749]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NTSQINQMLS DLNRVDFANV QEQASWVCQC DDNMVQRLET DFKMTLQQQS TLEQWAAWLD  60
   61 NVMMQALKPY EGRPSFPKAA RQFLLKWSFY SSMVIRDLTL RSAASFGSFH LIRLLYDEYM 120
  121 FYLVEHRVAQ ATGETPIAVM GEFGDLNAVS PGNLDKDEGS EVESEMDEEL DDSSEPQAKR 180
  181 EKTELSQAFP VGCMQPVLET GVQPSLLNPI HSEHIVTSTQ TIRQCSATGN TYTAV

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


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