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View Structure Prediction Details

Protein: baz-PB
Organism: Drosophila melanogaster
Length: 1520 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for baz-PB.

Description E-value Query
Range		 Subject
Range
baz-PA - The gene bazooka is referred to in FlyBase by the symbol Dmel\baz (CG5055, FBgn0000163). It is a pro...
 686.0 [0..61] [1520..40]

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Predicted Domain #1
Region A:
Residues: [1-127] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFDVPPKCPA LANKLGGLFG WRHTYKVAAK QEGIPHGQLH KSYSLTLPKR PPSPSTYSCV  60
   61 KPDSWVTVTH LQTQSGILDP DDCVRDVADD REQILAHFDD PGPDPGVPQG GGDGASGSSS 120
  121 VGTGSPD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.69897
Match: 2dazA
Description: No description for 2dazA was found.

Predicted Domain #2
Region A:
Residues: [128-328] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IFRDPTNTEA PTCPRDLSTP HIEVTSTTSG PMAGLGVGLM VRRSSDPNLL ASLKAEGSNK  60
   61 RWSAAAPHYA GGDSPERLFL DKAGGQLSPQ WEEDDDPSHQ LKEQLLHQQQ PHAANGGSSS 120
  121 GNHQPFARSG RLSMQFLGDG NGYKWMEAAE KLQNQPPAQQ TYQQGSHHAG HGQNGAYSSK 180
  181 SLPRESKRKE PLGQAYESIR E

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [329-424] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KDGEMLLIIN EYGSPLGLTA LPDKEHGGGL LVQHVEPGSR AERGRLRRDD RILEINGIKL  60
   61 IGLTESQVQE QLRRALESSE LRVRVLRGDR NRRQQR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.69897
Match: 1iu0A
Description: Synaptic protein PSD-95
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cytoskeletal protein binding 3.8598579619264 bayes_pls_golite062009
actin binding 2.68527541003929 bayes_pls_golite062009
binding 2.6196222853442 bayes_pls_golite062009
protein binding 2.35875654816667 bayes_pls_golite062009
actin filament binding 1.28158096626765 bayes_pls_golite062009
receptor binding 1.19273986711251 bayes_pls_golite062009
transporter activity 1.14862709059264 bayes_pls_golite062009
transmembrane transporter activity 1.03502943752333 bayes_pls_golite062009
beta-catenin binding 0.740091060781601 bayes_pls_golite062009
substrate-specific transporter activity 0.724101421194961 bayes_pls_golite062009
cyclase inhibitor activity 0.719523854982412 bayes_pls_golite062009
guanylate cyclase inhibitor activity 0.719523854982412 bayes_pls_golite062009
PDZ domain binding 0.71844819286977 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.520243659117793 bayes_pls_golite062009
cell adhesion molecule binding 0.403457741099606 bayes_pls_golite062009
protein domain specific binding 0.30840185305841 bayes_pls_golite062009
ErbB-2 class receptor binding 0.261656236234201 bayes_pls_golite062009
active transmembrane transporter activity 0.221504678128513 bayes_pls_golite062009
molecular transducer activity 0.211809989510755 bayes_pls_golite062009
signal transducer activity 0.211809989510755 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [425-550] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DSKVAEMVEV ATVSPTRKPH AAPVGTSLQV ANTRKLGRKI EIMLKKGPNG LGFSVTTRDN  60
   61 PAGGHCPIYI KNILPRGAAI EDGRLKPGDR LLEVDGTPMT GKTQTDVVAI LRGMPAGATV 120
  121 RIVVSR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 25.0
Match: 2fneA
Description: The crystal structure of the 13th PDZ domain of MPDZ
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [551-661] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QQELAEQADQ PAEKSAGVAV APSVAPPAVP AAAAPAPPIP VQKSSSARSL FTHQQQSQLN  60
   61 ESQHFIDAGS ESAASNDSLP PSSNSWHSRE ELTLHIPVHD TEKAGLGVSV K

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.35
Match: 2iwqA
Description: No description for 2iwqA was found.

Predicted Domain #6
Region A:
Residues: [662-923] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GKTCSNLNAS GSSASSGSNG LMKHDGDLGI FVKNVIHGGA ASRDGRLRMN DQLLSVNGVS  60
   61 LRGQNNAEAM ETLRRAMVNT PGKHPGTITL LVGRKILRSA SSSDILDHSN SHSHSHSNSS 120
  121 GGSNSNGSGN NNNSSSNASD NSGATVIYLS PEKREQRCNG GGGGGSAGNE MNRWSNPVLD 180
  181 RLTGGICSSN SAQPSSQQSH QQQPHPSQQQ QQQRRLPAAP VCSSAALRNE SYYMATNDNW 240
  241 SPAQMHLMTA HGNTALLIED DA

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.97
Match: 1z87A
Description: solution structure of the split PH-PDZ Supramodule of alpha-Syntrophin
Matching Structure (courtesy of the PDB):

Predicted Domain #7
Region A:
Residues: [924-999] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EPMSPTLPAR PHDGQHCNTS SANPSQNLAV GNQGPPINTV PGTPSTSSNF DATYSSQLSL  60
   61 ETNSGVEHFS RDALGR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #8
Region A:
Residues: [1000-1186] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RSISEKHHAA LDARETGTYQ RNKKLREERE RERRIQLTKS AVYGGSIESL TARIASANAQ  60
   61 FSGYKHAKTA SSIEQRETQQ QLAAAEAEAR DQLGDLGPSL GMKKSSSLES LQTMVQELQM 120
  121 SDEPRGHQAL RAPRGRGRED SLRAAVVSEP DASKPRKTWL LEDGDHEGGF ASQRNGPFQS 180
  181 SLNDGKH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 32.09691
Match: 1kjwA
Description: Psd-95; Guanylate kinase-like domain of Psd-95
Matching Structure (courtesy of the PDB):

Predicted Domain #9
Region A:
Residues: [1187-1324] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GCKSSRAKKP SILRGIGHMF RFGKNRKDGV VPVDNYAVNI SPPTSVVSTA TSPQLQQQQQ  60
   61 QQLQQHQQQQ QIPTAALAAL ERNGKPPAYQ PPPPLPAPNG VGSNGIHQND IFNHRYQHYA 120
  121 NYEDLHQQHQ QHQISGGD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #10
Region A:
Residues: [1325-1520] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 STTSISETLS ESTLECMRQQ VIRQRIKVEA ESRRHQHYHS QRSARSQDVS MHSTSSGSQP  60
   61 GSLAQPQAQS NGVRPMSSYY EYETVQQQRV GSIKHSHSSS ATSSSSSPIN VPHWKAAAMN 120
  121 GYSPASLNSS ARSRGPFVTQ VTIREQSSGG IPAHLLQQHQ QQQLQQQQPT YQTVQKMSGP 180
  181 SQYGSAAGSQ PHASKV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

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