YRC Public Data Repository - Protein Structure Prediction

Protein:	END4_STAA9
Organism:	Staphylococcus aureus subsp. aureus JH9
Length:	296 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for END4_STAA9.

Description	E-value	Query Range	Subject Range
END4_STAEP - (Q8CP25) Probable endonuclease IV (EC 3.1.21.2) (Endodeoxyribonuclease IV) END4_STAES - Probable endonuclease 4 OS=Staphylococcus epidermidis (strain ATCC 12228) GN=nfo PE=3 SV=1 END4_STAEQ - Probable endonuclease 4 OS=Staphylococcus epidermidis (strain ATCC 35984 / RP62A) GN=nfo PE=3 SV=1	269.0	[0..1]	[296..1]
END4_STAAB - Probable endonuclease 4 OS=Staphylococcus aureus (strain bovine RF122 / ET3-1) GN=nfo PE=3 SV=1 END4_STAA3 - Probable endonuclease 4 OS=Staphylococcus aureus (strain USA300) GN=nfo PE=3 SV=1 END4_STAAE - Probable endonuclease 4 OS=Staphylococcus aureus (strain Newman) GN=nfo PE=3 SV=1 gi\|221137866 - gi\|221137866\|ref\|ZP_03562668.1\| endonuclease IV [Staphylococcus aureus subsp. aureus str. JKD6008] END4_STAAT - Probable endonuclease 4 OS=Staphylococcus aureus (strain USA300 / TCH1516) GN=nfo PE=3 SV=1 gi\|221140023 - gi\|221140023\|ref\|ZP_03564516.1\| endonuclease IV [Staphylococcus aureus subsp. aureus str. JKD6009] END4_STAAC - Probable endonuclease 4 OS=Staphylococcus aureus (strain COL) GN=nfo PE=3 SV=1 END4_STAA8 - Probable endonuclease 4 OS=Staphylococcus aureus (strain NCTC 8325) GN=nfo PE=3 SV=1 gi\|87127990\|gb\|A... - endonuclease IV [Staphylococcus aureus subsp. aureus USA300], endonuclease IV [Staphylococcus aureus...	266.0	[0..1]	[296..1]
gi\|227851891, gi... - gi\|227899931\|ref\|ZP_04017736.1\| endonuclease IV [Staphylococcus aureus subsp. aureus TCH60], gi\|2278... END4_STAAR - Probable endonuclease 4 OS=Staphylococcus aureus (strain MRSA252) GN=nfo PE=3 SV=1	264.0	[0..1]	[296..1]
END4_BACLD - Probable endonuclease 4 OS=Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 1220...	264.0	[0..1]	[296..2]
END4_STAS1 - Probable endonuclease 4 OS=Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DS...	262.0	[0..1]	[296..1]
END4_STAHJ - Probable endonuclease 4 OS=Staphylococcus haemolyticus (strain JCSC1435) GN=nfo PE=3 SV=1	261.0	[0..1]	[296..1]
END4_BACSU - Probable endonuclease 4 OS=Bacillus subtilis GN=nfo PE=3 SV=1 gi\|221314760 - gi\|221314760\|ref\|ZP_03596565.1\| endonuclease IV [Bacillus subtilis subsp. subtilis str. NCIB 3610] END4_BACSU - Probable endonuclease 4 OS=Bacillus subtilis (strain 168) GN=nfo PE=3 SV=1 gi\|221319683 - gi\|221319683\|ref\|ZP_03600977.1\| endonuclease IV [Bacillus subtilis subsp. subtilis str. JH642] gi\|221323960 - gi\|221323960\|ref\|ZP_03605254.1\| endonuclease IV [Bacillus subtilis subsp. subtilis str. SMY]	258.0	[0..1]	[296..2]
gi\|69249143, gi\|... - gi\|69249143\|ref\|ZP_00604880.1\| AP endonuclease, family 2 [Enterococcus faecium DO], gi\|68194269\|gb\|E... gi\|48823997 - ref\|ZP_00285441.1\| COG0648: Endonuclease IV [Enterococcus faecium]	254.0	[0..1]	[296..1]
END4_BACHD - Probable endonuclease 4 OS=Bacillus halodurans GN=nfo PE=3 SV=1 END4_BACHD - Probable endonuclease 4 OS=Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 91...	253.0	[0..1]	[296..3]
gi\|227553543, gi... - gi\|227553543\|ref\|ZP_03983592.1\| endonuclease IV [Enterococcus faecalis HH22], gi\|227177321\|gb\|EEI582... gi\|227073613, gi... - gi\|227518924\|ref\|ZP_03948973.1\| endonuclease IV [Enterococcus faecalis TX0104], gi\|227073613\|gb\|EEI1... END4_ENTFA - Probable endonuclease 4 OS=Enterococcus faecalis GN=nfo PE=3 SV=1 gi\|238830653, gi... - gi\|238856820\|ref\|ZP_04647080.1\| apurinic endonuclease [Enterococcus faecalis TUSoD Ef11], gi\|2388306... END4_ENTFA - Probable endonuclease 4 OS=Enterococcus faecalis (strain ATCC 700802 / V583) GN=nfo PE=3 SV=1	252.0	[0..1]	[296..1]

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Predicted Domain #1

Region A:
Residues: [1-296]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLLGSHVSMS GKKMLEGSAI EAYEYGETTF MIYTGAPQNT RRKSIEDLNI TKGHEVMEKY  60
   61 GLSNIVVHAP YIINIANTTK PETFNLGVDF LQQEIERTQA IGAKDIVLHP GAHVGAGVDA 120
  121 GINKIIEGLN EVLTNDNNVR IALETMAGKG TEIGRSFEEL ARIIDGVHNN ERLSVCFDTC 180
  181 HTHDAGYNVK EDFDGVLNEF DKIIGVDRIK VVHVNDSKND RGAQKDRHEN IGFGYIGFDA 240
  241 LNYIVHHDSF KDIPKILETP YVGEDKKNKK PPYKLEIEML KQQQFDPELK NKVMQQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	62.522879
Match:	1xp3A
Description:	Crystal Structure of Endonuclease IV (BA4508) from Bacillus anthracis at 2.57A Resolution.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.66019571685402	bayes_pls_golite062009
deoxyribonuclease activity	0.97458966528485	bayes_pls_golite062009
DNA-(apurinic or apyrimidinic site) lyase activity	0.36517654808269	bayes_pls_golite062009
endodeoxyribonuclease activity	0.19550406288989	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: