YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|109128441
Organism:	Macaca mulatta
Length:	282 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|109128441.

Description	E-value	Query Range	Subject Range
gi\|76640366 - gi\|76640366\|ref\|XP_875974.1\| PREDICTED: similar to seven in absentia homolog 1 isoform b [Bos taurus...	6.0E-80	[1..282]	[254..535]
gi\|50753723 - gi\|50753723\|ref\|XP_414105.1\| PREDICTED: similar to SIAH1 protein [Gallus gallus]	3.0E-79	[1..282]	[370..651]
gi\|55749557, gi\|... - gi\|55749557\|ref\|NP_001006611.1\| seven in absentia homolog 1 isoform b [Homo sapiens], gi\|27503514\|gb... CCDS32444.1_1 - null gi\|109128439 - gi\|109128439\|ref\|XP_001114300.1\| PREDICTED: seven in absentia homolog 1 (Drosophila) isoform 1 [Maca... gi\|55749557 - ref\|NP_001006611.1\| seven in absentia homolog 1 isoform b [Homo sapiens] ENSPTRT00000014925 - null	7.0E-78	[1..282]	[32..313]
gi\|68389919 - gi\|68389919\|ref\|XP_707669.1\| PREDICTED: similar to Seven in absentia 1A isoform 2 [Danio rerio]	9.0E-78	[1..282]	[53..334]
gi\|57043872 - gi\|57043872\|ref\|XP_544419.1\| PREDICTED: similar to seven in absentia homolog 1 isoform b isoform 1 [...	1.0E-77	[1..282]	[32..313]
gi\|60654479 - gi\|60654479\|gb\|AAX29930.1\| seven in absentia-like 1 [synthetic construct]	1.0E-76	[1..282]	[1..282]
gi\|62751353, gi\|... - gi\|62751353\|ref\|NP_001015836.1\| seven in absentia homolog 1 [Xenopus (Silurana) tropicalis], gi\|5847... gi\|49117837, gi\|... - gi\|49117837\|gb\|AAH72747.1\| MGC79105 protein [Xenopus laevis], gi\|148231169\|ref\|NP_001085438.1\| MGC79...	1.0E-76	[1..282]	[1..282]
SIAH1_RAT - E3 ubiquitin-protein ligase SIAH1 OS=Rattus norvegicus GN=Siah1 PE=1 SV=2 tr\|G3HYR1\|G3HYR1... - E3 ubiquitin-protein ligase OS=Cricetulus griseus GN=H671_3g8983 PE=3 SV=1 SIA1A_MOUSE - E3 ubiquitin-protein ligase SIAH1A OS=Mus musculus GN=Siah1a PE=1 SV=1	2.0E-76	[1..282]	[1..282]

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Predicted Domain #1

Region A:
Residues: [1-77]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRQTATALP TGTSKCPPSQ RVPALTGTTA SNNDLASLFE CPVCFDYVLP PILQCQSGHL  60
   61 VCSNCRPKLT CCPTCRG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	10.69897
Match:	1rmdA
Description:	RAG1 DIMERIZATION DOMAIN
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ubiquitin-protein ligase activity	5.32809533104435	bayes_pls_golite062009
small conjugating protein ligase activity	5.17943669371679	bayes_pls_golite062009
acid-amino acid ligase activity	4.2482314105959	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	3.07217714843839	bayes_pls_golite062009
binding	2.15929427993458	bayes_pls_golite062009
protein binding	1.49775478023418	bayes_pls_golite062009
small conjugating protein-specific protease activity	0.786612602432575	bayes_pls_golite062009
ligase activity	0.63517530468004	bayes_pls_golite062009
peptidase activity	0.629020501929934	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	0.616462655649223	bayes_pls_golite062009
ubiquitin-specific protease activity	0.549461161056205	bayes_pls_golite062009
transcription regulator activity	0.181063140818134	bayes_pls_golite062009
cysteine-type peptidase activity	0.159023519781458	bayes_pls_golite062009
hydrolase activity	0.156835837705934	bayes_pls_golite062009
catalytic activity	0.14112008370434	bayes_pls_golite062009
nucleic acid binding	0.125491277540945	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [78-282]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PLGSIRNLAM EKVANSVLFP CKYASSGCEI TLPHTEKADH EELCEFRPYS CPCPGASCKW  60
   61 QGSLDAVMPH LMHQHKSITT LQGEDIVFLA TDINLPGAVD WVMMQSCFGF HFMLVLEKQE 120
  121 KYDGHQQFFA IVQLIGTRKQ AENFAYRLEL NGHRRRLTWE ATPRSIHEGI ATAIMNSDCL 180
  181 VFDTSIAQLF AENGNLGINV TISMC

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	57.522879
Match:	2a25A
Description:	Crystal structure of Siah1 SBD bound to the peptide EKPAAVVAPITTG from SIP
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: