YRC Public Data Repository - Protein Structure Prediction

Protein:	LEG2_MOUSE
Organism:	Mus musculus
Length:	130 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LEG2_MOUSE.

Description	E-value	Query Range	Subject Range
gi\|185134396, gi... - gi\|6681410\|dbj\|BAA88670.1\| galectin like protein [Oncorhynchus mykiss], gi\|185134396\|ref\|NP_00111766...	157.0	[0..2]	[130..13]
gi\|191126 - gi\|191126\|gb\|AAA36995.1\| 14 kDa beta-galactoside-binding lectin LEG1_CRIGR - Galectin-1 OS=Cricetulus griseus GN=LGALS1 PE=1 SV=2	156.0	[0..1]	[130..1]
gi\|52851 - gi\|52851\|emb\|CAA34206.1\| unnamed protein product [Mus sp.]	154.0	[0..1]	[128..128]
LEG3_MOUSE - Galectin-3 OS=Mus musculus GN=Lgals3 PE=1 SV=3	154.0	[0..1]	[128..128]
gi\|87044899 - gi\|87044899\|ref\|NP_001034266.1\| galectin-9 isoform 1 [Bos taurus]	154.0	[0..3]	[130..15]
gi\|1083173 - gi\|1083173\|pir\|\|A54909 carbohydrate-binding protein CBP30 - hamster LEG3_CRILO - Galectin-3 OS=Cricetulus longicaudatus GN=LGALS3 PE=2 SV=2	154.0	[0..1]	[126..109]
gi\|109149582 - gi\|109149582\|ref\|XP_001083427.1\| PREDICTED: lectin, galactoside-binding, soluble, 1 (galectin 1) iso...	154.0	[0..1]	[129..1]
gi\|73948388 - gi\|73948388\|ref\|XP_855387.1\| PREDICTED: similar to Galectin-4 (Lactose-binding lectin 4) (L-36 lacto...	154.0	[0..2]	[129..63]

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Predicted Domain #1

Region A:
Residues: [1-130]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEKFEVKDL NMKPGMSLKI KGKIHNDVDR FLINLGQGKE TLNLHFNPRF DESTIVCNTS  60
   61 EGGRWGQEQR ENHMCFSPGS EVKITITFQD KDFKVTLPDG HQLTFPNRLG HNQLHYLSMG 120
  121 GLQISSFKLE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	32.045757
Match:	1hlcA
Description:	S-lectin, different isoforms
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
sugar binding	3.34064405064299	bayes_pls_golite062009
glycosaminoglycan binding	2.70103238455595	bayes_pls_golite062009
binding	2.40096962515027	bayes_pls_golite062009
polysaccharide binding	2.35851723238763	bayes_pls_golite062009
monosaccharide binding	2.09529521879228	bayes_pls_golite062009
carbohydrate binding	1.90829797790335	bayes_pls_golite062009
protein binding	1.80794638640093	bayes_pls_golite062009
heparin binding	1.60966215355794	bayes_pls_golite062009
extracellular matrix binding	1.41229380365824	bayes_pls_golite062009
fibronectin binding	1.10309233016451	bayes_pls_golite062009
galactoside binding	1.08479183125487	bayes_pls_golite062009
pattern binding	0.969915174528009	bayes_pls_golite062009
receptor binding	0.9012250808046	bayes_pls_golite062009
extracellular matrix structural constituent	0.5068011550246	bayes_pls_golite062009
transcription regulator activity	0.372701974560119	bayes_pls_golite062009
nucleic acid binding	0.216086300988177	bayes_pls_golite062009
DNA binding	0.157628282318248	bayes_pls_golite062009
growth factor activity	0.119475011376319	bayes_pls_golite062009
fibroblast growth factor 2 binding	0.0714976455077903	bayes_pls_golite062009
fibrinogen binding	0.0714976455077903	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: