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View Structure Prediction Details

Protein: LEG1_MOUSE
Organism: Mus musculus
Length: 135 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LEG1_MOUSE.

Description E-value Query
Range		 Subject
Range
gi|191126 - gi|191126|gb|AAA36995.1| 14 kDa beta-galactoside-binding lectin
LEG1_CRIGR - Galectin-1 OS=Cricetulus griseus GN=LGALS1 PE=1 SV=2
 181.0 [0..1] [135..1]
gi|23342428|emb|... - unnamed protein product [Rattus sp.]
LEG1_RAT - Galectin-1 OS=Rattus norvegicus GN=Lgals1 PE=1 SV=2
 179.0 [0..1] [135..1]
gi|109149582 - gi|109149582|ref|XP_001083427.1| PREDICTED: lectin, galactoside-binding, soluble, 1 (galectin 1) iso...
 179.0 [0..1] [135..1]
gi|12805209 - gi|12805209|gb|AAH02063.1| Lectin, galactose binding, soluble 1 [Mus musculus]
 177.0 [0..1] [135..1]
gi|30584667, gi|... - gi|61369162|gb|AAX43294.1| lectin galactoside-binding soluble 1 [synthetic construct], gi|61369156|g...
 177.0 [0..1] [135..1]
LGALS1 - lectin, galactoside-binding, soluble, 1
gi|61358976, gi|... - gi|61358983|gb|AAX41650.1| lectin galactoside-binding soluble 1 [synthetic construct], gi|61358976|g...
HGNC:6561|MIM:15... - galactoside-binding, soluble, 1
gi|114686337, gi... - gi|114686337|ref|XP_001162104.1| PREDICTED: hypothetical protein isoform 3 [Pan troglodytes], gi|114...
 177.0 [0..1] [135..1]
LEG1_SHEEP - Galectin-1 OS=Ovis aries GN=LGALS1 PE=1 SV=2
 176.0 [0..1] [135..1]
LEG1_PONPY - Galectin-1 - Pongo pygmaeus (Orangutan)
LEG1_PONAB - Galectin-1 OS=Pongo abelii GN=LGALS1 PE=2 SV=3
 176.0 [0..1] [135..1]
LEG1_BOVIN - Galectin-1 OS=Bos taurus GN=LGALS1 PE=1 SV=2
 175.0 [0..1] [135..1]

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Predicted Domain #1
Region A:
Residues: [1-135] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MACGLVASNL NLKPGECLKV RGEVASDAKS FVLNLGKDSN NLCLHFNPRF NAHGDANTIV  60
   61 CNTKEDGTWG TEHREPAFPF QPGSITEVCI TFDQADLTIK LPDGHEFKFP NRLNMEAINY 120
  121 MAADGDFKIK CVAFE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 44.0
Match: 1gzwA
Description: X-RAY CRYSTAL STRUCTURE OF HUMAN GALECTIN-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
glycosaminoglycan binding 2.70103238455595 bayes_pls_golite062009
binding 2.40096962515027 bayes_pls_golite062009
polysaccharide binding 2.35851723238763 bayes_pls_golite062009
monosaccharide binding 2.09529521879228 bayes_pls_golite062009
carbohydrate binding 1.90829797790335 bayes_pls_golite062009
protein binding 1.80794638640093 bayes_pls_golite062009
heparin binding 1.60966215355794 bayes_pls_golite062009
extracellular matrix binding 1.41229380365824 bayes_pls_golite062009
sugar binding 1.27754120053722 bayes_pls_golite062009
fibronectin binding 1.10309233016451 bayes_pls_golite062009
galactoside binding 1.08479183125487 bayes_pls_golite062009
receptor binding 0.9012250808046 bayes_pls_golite062009
pattern binding 0.83687933614214 bayes_pls_golite062009
extracellular matrix structural constituent 0.5068011550246 bayes_pls_golite062009
transcription regulator activity 0.372701974560119 bayes_pls_golite062009
nucleic acid binding 0.216086300988177 bayes_pls_golite062009
DNA binding 0.157628282318248 bayes_pls_golite062009
growth factor activity 0.119475011376319 bayes_pls_golite062009
fibroblast growth factor 2 binding 0.0714976455077903 bayes_pls_golite062009
fibrinogen binding 0.0714976455077903 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle