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View Structure Prediction Details

Protein: TLX2_MOUSE
Organism: Mus musculus
Length: 284 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TLX2_MOUSE.

Description E-value Query
Range
Subject
Range
gi|109103483 - gi|109103483|ref|XP_001110250.1| PREDICTED: T-cell leukemia homeobox 2 isoform 2 [Macaca mulatta]
135.0 [0..1] [284..1]
TLX2 - T-cell leukemia homeobox 2
gi|167773147 - gi|167773147|gb|ABZ92008.1| T-cell leukemia homeobox 2 [synthetic construct]
135.0 [0..1] [284..1]
gi|114578297 - gi|114578297|ref|XP_001161223.1| PREDICTED: T-cell leukemia, homeobox 2 isoform 2 [Pan troglodytes]
134.0 [0..1] [284..1]
gi|109472220 - gi|109472220|ref|XP_001054603.1| PREDICTED: similar to T-cell leukemia homeobox protein 2 (Homeobox ...
133.0 [0..1] [284..1]
gi|122891179, gi... - gi|37606068|emb|CAE49441.1| T-cell leukemia, homeobox 1 [Danio rerio], gi|37606033|emb|CAE50907.1| T...
133.0 [0..7] [279..6]
gi|61829169 - gi|61829169|ref|XP_584418.1| PREDICTED: similar to homeobox protein [Bos taurus]
130.0 [0..1] [284..1]
gi|73980953 - gi|73980953|ref|XP_855075.1| PREDICTED: similar to T-cell leukemia homeobox protein 2 (Homeobox prot...
125.0 [0..1] [284..1]

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Predicted Domain #1
Region A:
Residues: [1-106]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEPAVLAAHH LPHHEPISFG IDQILSGPEP PGGGLGPGQS GQSHGESAAF SSGFHGASGY  60
   61 APAGSLASLP RGSGVGPGGV IRVPAHRPLP VPPPSGAAPA VPGPSG

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [107-284]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LGGAGGLAGL TFPWMDSGRR FAKDRLTAAL SPFSGTRRIG HPYQNRTPPK RKKPRTSFSR  60
   61 SQVLELERRF LRQKYLASAE RAALAKALRM TDAQVKTWFQ NRRTKWRRQT AEEREAERHR 120
  121 AGRLLLHLQQ DALPRPLRPP LPPDPLCLHN SSLFALQNLQ PWAEDNKVAS VSGLASVV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 26.0
Match: 1homA
Description: DETERMINATION OF THE THREE-DIMENSIONAL STRUCTURE OF THE ANTENNAPEDIA HOMEODOMAIN FROM DROSOPHILA IN SOLUTION BY 1H NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.16896789933192 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
sequence-specific DNA binding 2.41271657675151 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
transcription activator activity 1.77700860354597 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.73068440195944 bayes_pls_golite062009
chromatin binding 1.68956710349366 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
protein binding 0.830419844171551 bayes_pls_golite062009
transcription corepressor activity 0.25931464844298 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle