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View Structure Prediction Details

Protein: gi|114650545
Organism: Pan troglodytes
Length: 252 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|114650545.

Description E-value Query
Range
Subject
Range
gi|46575936, gi|... - gi|76825284|gb|AAI07005.1| Fibroblast growth factor 14 [Mus musculus], gi|46575936|ref|NP_997550.1| ...
gi|3299786, gi|1... - gi|3299786|dbj|BAA31544.1| fibroblast growth factor 14b [Rattus norvegicus], gi|149050272|gb|EDM0259...
1.0E-91 [1..252] [1..252]
gi|45382137, gi|... - gi|6911123|gb|AAF31393.1|AF199606_1 fibroblast growth factor homologous factor 4 isoform 1B [Gallus ...
6.0E-87 [1..252] [1..253]
gi|19070525 - gi|19070525|gb|AAL83904.1|AF348523_1 fibroblast growth factor-like factor-4D [Rattus norvegicus]
4.0E-67 [53..252] [12..211]
gi|28191242 - gi|28191242|gb|AAO33291.1| fibroblast growth factor-like protein [Meleagris gallopavo]
9.0E-65 [45..252] [27..236]
gi|109132469 - gi|109132469|ref|XP_001084216.1| PREDICTED: fibroblast growth factor 13 isoform 2 [Macaca mulatta]
gi|221045728, gi... - gi|221045728|dbj|BAH14541.1| unnamed protein product [Homo sapiens], gi|221041872|dbj|BAH12613.1| un...
2.0E-64 [45..252] [46..255]
gi|148230685, gi... - gi|49899696|gb|AAH76721.1| Fgf13-prov protein [Xenopus laevis], gi|148230685|ref|NP_001086499.1| fib...
7.0E-64 [45..252] [46..255]
gi|114650543 - gi|114650543|ref|XP_001150157.1| PREDICTED: fibroblast growth factor 14 isoform 1 [Pan troglodytes]
gi|109121204 - gi|109121204|ref|XP_001093573.1| PREDICTED: fibroblast growth factor 14 isoform 2 [Macaca mulatta]
FGF14 - fibroblast growth factor 14
2.0E-63 [63..252] [58..247]
gi|73989458 - gi|73989458|ref|XP_542656.2| PREDICTED: similar to fibroblast growth factor 14 [Canis familiaris]
2.0E-63 [63..252] [58..247]

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Predicted Domain #1
Region A:
Residues: [1-64]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVKPVPLFRR TDFKLLLCNH KDLFFLRVSK LLDCFSPKSM WFLWNIFSKG THMLQCLCGK  60
   61 SLKK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.402 0.055 growth factor activity a.4.5 "Winged helix" DNA-binding domain
View Download 0.389 0.036 growth factor activity a.3.1 Cytochrome c
View Download 0.401 0.017 growth factor activity a.138.1 Multiheme cytochromes
View Download 0.409 0.008 growth factor activity a.65.1 Annexin
View Download 0.416 0.003 growth factor activity a.56.1 CO dehydrogenase ISP C-domain like

Predicted Domain #2
Region A:
Residues: [65-252]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NKNPTDPQLK GIVTRLYCRQ GYYLQMHPDG ALDGTKDDST NSTLFNLIPV GLRVVAIQGV  60
   61 KTGLYIAMNG EGYLYPSELF TPECKFKESV FENYYVIYSS MLYRQQESGR AWFLGLNKEG 120
  121 QAMKGNRVKK TKPAAHFLPK PLEVAMYREP SLHDVGETVP KPGVTPSKST SASAIMNGGK 180
  181 PVNKSKTT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 47.522879
Match: 1q1uA
Description: Crystal structure of human FHF1b (FGF12b)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.90110516688922 bayes_pls_golite062009
receptor binding 2.16557070623757 bayes_pls_golite062009
protein binding 1.94397222237906 bayes_pls_golite062009
growth factor activity 1.45668559810417 bayes_pls_golite062009
cytokine activity 0.491912278395019 bayes_pls_golite062009
fibroblast growth factor receptor binding 0.379391310291065 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle