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View Structure Prediction Details

Protein: cos-PA, FBpp0307854
Organism: Drosophila melanogaster
Length: 1201 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for cos-PA, FBpp0307854.

Description E-value Query
Range
Subject
Range
gi|29421214 - gi|29421214|dbj|BAA31614.3| KIAA0639 protein [Homo sapiens]
362.0 [0..92] [1187..12]

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Predicted Domain #1
Region A:
Residues: [1-90]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEIPIQVAVR IFPHRELKDL LRSFGPTEPK KDAQAVDEGA DSKDSEAQVP AAEKDNPSIS  60
   61 ETDPNGNAEQ DSAADSKTIP DANGNDSGQK 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [91-408]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DYPDSAYCVQ AIPISASALG LPSALPGGDP MDSIAAGLIQ VGPHTVPVTH ALPSSSSQEQ  60
   61 VYHQTVFPLI TLFLEGFDAS VVTYGQRGQG KSYTLYGNVQ DPTLTDSTEG VVQLCVRDIF 120
  121 SHISLHPERT YAINVGFVEI CGGDVCDLLG MGNIHCTNVD AVFHWLQVGL SARQSLPAHT 180
  181 LFTLTLEQQW VSKEGLLQHR LSTASFSDLC GTERCGDQPP GRPLDAGLCM LEQVISTLTD 240
  241 PGLMYGVNGN IPYGQTTLTT LLKDSFGGRA QTLVILCVSP LEEHLPETLG NLQFAFKVQC 300
  301 VRNFVIMNTY SDDNTMIV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 87.30103
Match: 1gojA
Description: Kinesin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
microtubule motor activity 7.68336791348661 bayes_pls_golite062009
plus-end-directed microtubule motor activity 4.97507344344589 bayes_pls_golite062009
motor activity 4.04927796049806 bayes_pls_golite062009
transporter activity 3.10463051760206 bayes_pls_golite062009
transmembrane transporter activity 2.95886887664984 bayes_pls_golite062009
nucleoside-triphosphatase activity 2.95079405147356 bayes_pls_golite062009
pyrophosphatase activity 2.87427509025394 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 2.85499564954033 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.85178667290149 bayes_pls_golite062009
smoothened binding 2.78675393035288 bayes_pls_golite062009
tubulin binding 2.67743463093593 bayes_pls_golite062009
microtubule binding 2.59155206524122 bayes_pls_golite062009
hydrolase activity 2.55157966585974 bayes_pls_golite062009
active transmembrane transporter activity 2.50494515048649 bayes_pls_golite062009
primary active transmembrane transporter activity 2.39629638016861 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 2.39600931083427 bayes_pls_golite062009
ATPase activity 2.39535714892224 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 2.36051733655256 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 2.35906629925754 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 2.35679406876731 bayes_pls_golite062009
ATPase activity, coupled 2.24901251684901 bayes_pls_golite062009
binding 2.21604035604783 bayes_pls_golite062009
protein transporter activity 1.71214667007262 bayes_pls_golite062009
substrate-specific transporter activity 1.65609907941094 bayes_pls_golite062009
nucleic acid binding 1.6268310953221 bayes_pls_golite062009
DNA binding 1.52986172845338 bayes_pls_golite062009
transcription regulator activity 1.49328374516529 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 1.3182108176243 bayes_pls_golite062009
microfilament motor activity 1.28029120876672 bayes_pls_golite062009
protein binding 1.22129154759482 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
cytoskeletal protein binding 0.990232056623698 bayes_pls_golite062009
purine nucleotide binding 0.929901285538132 bayes_pls_golite062009
nucleotide binding 0.922442819194247 bayes_pls_golite062009
purine ribonucleotide binding 0.920987930180051 bayes_pls_golite062009
ribonucleotide binding 0.920926158369519 bayes_pls_golite062009
GTPase activity 0.83849854735032 bayes_pls_golite062009
ion transmembrane transporter activity 0.704934361725919 bayes_pls_golite062009
molecular transducer activity 0.683309012097319 bayes_pls_golite062009
signal transducer activity 0.683309012097319 bayes_pls_golite062009
transmembrane receptor activity 0.661834961742057 bayes_pls_golite062009
receptor activity 0.633514002718998 bayes_pls_golite062009
guanyl nucleotide binding 0.58271536409458 bayes_pls_golite062009
GTP binding 0.5687070753098 bayes_pls_golite062009
guanyl ribonucleotide binding 0.54474544621658 bayes_pls_golite062009
ATP binding 0.41092997612902 bayes_pls_golite062009
adenyl ribonucleotide binding 0.385813421701492 bayes_pls_golite062009
adenyl nucleotide binding 0.377870145186619 bayes_pls_golite062009
actin-dependent ATPase activity 0.36110509588725 bayes_pls_golite062009
transcription factor activity 0.342904707338268 bayes_pls_golite062009
cation transmembrane transporter activity 0.282397764628576 bayes_pls_golite062009
signal recognition particle binding 0.20866768220789 bayes_pls_golite062009
structural constituent of ribosome 0.208665086324262 bayes_pls_golite062009
minus-end-directed microtubule motor activity 0.068779631341469 bayes_pls_golite062009
structural constituent of cytoskeleton 0.028319099023125 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [409-507]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QPAEPVPESN SSAGPLSQAG PGDNFGLQFA ASQWSKLVTN AEGLFSKLID SKLITEVEKE  60
   61 QIEEWLFLKQ ECEECLSSTE AMRQQKQLVP ILEAEEPED

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [508-1201]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VNSEAANSES PNSDNENDTD NESHRPDLDD KIESLMEEFR DKTDALILEK HAEYLSKHPK  60
   61 AVMQSQDREI EAQPPEENGD DRKVSIGSRR RSVQPGASLS TAELAMLNRV ASQQPPPPID 120
  121 PESVVDPLES SSGEGIRQAA LAAAAATAPI EQLQKKLRKL VAEIEGKQRQ LREIEETIQV 180
  181 KQNIIAELVK NSDTRSHAKQ RFHKKRAKLE AECDKAKKQL GKALVQGRDQ SEIERWTTII 240
  241 GHLERRLEDL SSMKHIAGES GQKVKKLQQS VGESRKQADD LQKKLRKECK LRCQMEAELA 300
  301 KLRESRETGK ELVKAQGSPE QQGRQLKAVQ ARITHLNHIL REKSDNLEEQ PGPEQQETLR 360
  361 HEIRNLRGTR DLLLEERCHL DRKLKRDKVL TQKEERKLLE CDEAIEAIDA AIEFKNEMIT 420
  421 GHRSIDTSDR IQREKGEQML MARLNRLSTE EMRTLLYKYF TKVIDLRDSS RKLELQLVQL 480
  481 ERERDAWEWK ERVLSNAVRQ ARLEGERNAV LLQRQHEMKL TLMLRHMAEE TSASSASYGE 540
  541 RALAPACVAP PVQASSDFDY DHFYKGGGNP SKALIKAPKP MPTGSALDKY KDKEQRSGRN 600
  601 IFAKFHVLTR YASAAAAGSS GSTAEESTAL IESTTTATAT TTSTTTTGAV GKVKDKALVS 660
  661 FRPEQLKRLM PAPTATKVTR QKNKIIIQDA SRRN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.522879
Match: 1i84S
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle