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View Structure Prediction Details

Protein: CAP-PF
Organism: Drosophila melanogaster
Length: 811 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CAP-PF.

Description E-value Query
Range
Subject
Range
gi|14669818 - gi|14669818|dbj|BAB62019.1| DCAPL3 [Drosophila melanogaster]
354.0 [0..1] [811..14]

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Predicted Domain #1
Region A:
Residues: [1-217]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFAPKFKARA PPGSGVWTPY GSSGDLNQSG ATSATPPPPP PPSLPVWTPQ PSPVLSGRKE  60
   61 FRPVRFESPT LPRRYTAQQQ QKTTTTIPPW SSAENGEGGP PPTAPASLNS VNSNSDYAET 120
  121 DCSGHFGPVA PSASVSDKIR TFERSSSNSE LQRPFVRRQL SDASRPAYRP NEVIYKVKHE 180
  181 YMSEPETGSD RPRKMAQLGR RQYDGIGPVT NDGMPII

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [218-341]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LRSEVKEPHQ HEWYKRLYQT IHKQKNGDDF VIRYKCPRAR PSYKSNGYVS EPEPNYDSDY  60
   61 STVRYRTQNP HRVQSVSSAV NVRNLNQDEK LYGTMPNPIK SAQNSYKNQP GRIENYTTGH 120
  121 SSVS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [342-555]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EKEKKEWWDE VMDIFNGNLE QSKLSPLYTE GNLSRALAKE SGYTSDSNLV FRKKEVPVSS  60
   61 PLSPVEQKQA YKSLQAGGEP PLLGFRKPAP EKPRDLDPNA PPIPPQPPVK GLSSYDFPYS 120
  121 TDTVDGSDVN IHFKTPIRHE QRQNLSEEEL AIRQAEHMQK LYHEERRRKY LQELQDMNSR 180
  181 RHTDNFTPSQ KSPIALNRYD DFPTDVTLKS LVGP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [556-811]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KTVARALFNF QGQTSKELSF RKGDTIYIRR QIDANWYEGE HNAMIGLLPA SYVEIVSRDG  60
   61 ARTPSKRPSE GQARAKYNFQ AQSGIELSLN KGELVTLTRR VDGNWFEGKI ANRKGIFPCS 120
  121 YVEVLTDIGA EDIAARTTTV ITSQSTTNLR PNLDVLRTNI NNEFNTLTQN GAQPPNGILK 180
  181 ETRTLHKTDA LHVDTSSEPL AYRALYKYRP QNSDELELLE GDVVHVLEKC DDGWFVGTSQ 240
  241 RTGCFGTFPG NYVERA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 36.522879
Match: 1griA
Description: Growth factor receptor-bound protein 2 (GRB2), N- and C-terminal domains; Growth factor receptor-bound protein 2 (GRB2)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.13376047180398 bayes_pls_golite062009
protein binding 1.03382488697656 bayes_pls_golite062009
signal transducer activity 0.69727426993974 bayes_pls_golite062009
molecular transducer activity 0.69727426993974 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle