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View Structure Prediction Details

Protein: Cyp6a21-PA
Organism: Drosophila melanogaster
Length: 504 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Cyp6a21-PA.

Description E-value Query
Range		 Subject
Range
gi|58293940 - gi|58293940|gb|AAW69913.1| cytochrome P450 CYP6BB1v4 [Ochlerotatus sollicitans]
 395.0 [0..1] [504..1]

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Predicted Domain #1
Region A:
Residues: [1-504] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVGTVLLTA LLALVGYLLM KWRSTMRHWQ DLGIPCEEPH ILMGSMKGVR TARSFNEIWT  60
   61 SYYNKFRGSG PFAGFYWFRR PAVFVLETSL AKQILIKEFN KFTDRGFFHN PEDDPLSGQL 120
  121 FLLDGQKWRT MRNKLSSTFT SGKMKYMFPT VVKVANEFTD VFGQNVAKSP VVEVRELLAR 180
  181 FTTDVIGTCA FGIECSSLKD PDAEFREMGR RSLTEQRLGP VGIGFVNSFP NLARRLHMKM 240
  241 TAEPIERFFM RIVRETVAFR EQNNIRRNDF MDQLIDLKNK PLMVSQSGES VNLTIEEIAA 300
  301 QAFVFFAAGF ETSSTTMGFA LYELAQNQDI QNRVRKECQE VIEKCNGELN YESMKDLVYL 360
  361 DQVVSETLRL YTVLPVLNRE CLEDYEVPGH PKYVIKKGMP VLIPCGAMHR DEKLYANPNT 420
  421 FNPDNFSPER VKERDSVEWL PFGDGPRNCI GMRFGQMQAR IGLALLIKDF KFSVCEKTTI 480
  481 PMTYNKEMFL IASNSGIYLK AERV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 104.0
Match: 1tqnA
Description: Crystal Structure of Human Microsomal P450 3A4
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
arachidonic acid monooxygenase activity 6.76823710927794 bayes_pls_golite062009
fatty acid (omega-1)-hydroxylase activity 6.3313834755701 bayes_pls_golite062009
monooxygenase activity 5.57229509004705 bayes_pls_golite062009
steroid hydroxylase activity 5.04794778387361 bayes_pls_golite062009
arachidonic acid epoxygenase activity 4.80764258881036 bayes_pls_golite062009
steroid 17-alpha-monooxygenase activity 3.99744233006162 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 3.68151610133025 bayes_pls_golite062009
fluorene oxygenase activity 3.16634614522939 bayes_pls_golite062009
demethylase activity 2.80780658333504 bayes_pls_golite062009
oxygen binding 2.77495508953933 bayes_pls_golite062009
retinoic acid 4-hydroxylase activity 2.60901411823382 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 2.56821164444595 bayes_pls_golite062009
thromboxane-A synthase activity 2.45281910634006 bayes_pls_golite062009
oxysterol 7-alpha-hydroxylase activity 2.36480328243514 bayes_pls_golite062009
oxidoreductase activity 2.35847923992364 bayes_pls_golite062009
sterol 14-demethylase activity 2.33937429425924 bayes_pls_golite062009
steroid 7-alpha-hydroxylase activity 2.21042366294727 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen 2.15105968497418 bayes_pls_golite062009
retinoid binding 1.91237853759594 bayes_pls_golite062009
vitamin D 24-hydroxylase activity 1.81919676974797 bayes_pls_golite062009
isoprenoid binding 1.78853880472253 bayes_pls_golite062009
vitamin D3 25-hydroxylase activity 1.65825585934141 bayes_pls_golite062009
vitamin D 25-hydroxylase activity 1.65825585934141 bayes_pls_golite062009
corticosterone 18-monooxygenase activity 1.64204907906991 bayes_pls_golite062009
steroid 11-beta-monooxygenase activity 1.64204907906991 bayes_pls_golite062009
retinoic acid binding 1.55035199545719 bayes_pls_golite062009
electron carrier activity 1.48516712188486 bayes_pls_golite062009
arachidonic acid 11,12-epoxygenase activity 1.48500938886158 bayes_pls_golite062009
testosterone 6-beta-hydroxylase activity 1.4661447981611 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1.46109575978397 bayes_pls_golite062009
binding 1.2866152532988 bayes_pls_golite062009
25-hydroxycholecalciferol-24-hydroxylase activity 1.06487564122685 bayes_pls_golite062009
ecdysteroid 25-hydroxylase activity 0.89030345144459 bayes_pls_golite062009
flavonoid 3'-monooxygenase activity 0.89030345144459 bayes_pls_golite062009
catalytic activity 0.608111453189583 bayes_pls_golite062009
iron ion binding 0.529598228513719 bayes_pls_golite062009
cation binding 0.510556740388808 bayes_pls_golite062009
metal ion binding 0.510556740388808 bayes_pls_golite062009
ion binding 0.503326724714616 bayes_pls_golite062009
transition metal ion binding 0.450436868179747 bayes_pls_golite062009
cholesterol monooxygenase (side-chain-cleaving) activity 0.276594551871869 bayes_pls_golite062009
1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity 0.203772707673481 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
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