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View Structure Prediction Details

Protein: FBpp0309018, dup-PA
Organism: Drosophila melanogaster
Length: 743 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FBpp0309018, dup-PA.

Description E-value Query
Range
Subject
Range
gi|70878483 - gi|70878483|gb|EAN91735.1| trans-sialidase, putative [Trypanosoma cruzi]
gi|71649745 - gi|71649745|ref|XP_813586.1| trans-sialidase [Trypanosoma cruzi strain CL Brener]
327.0 [0..2] [687..760]

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Predicted Domain #1
Region A:
Residues: [1-158]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAQPSVAAFF TNRKRAALDD AISIKNRRLV EPAETVSPAS APSQLPAGDQ DADLDTLKAA  60
   61 ATGMRTRSGR TARLIVTAAQ ESKKKTPAAA KMEPHIKQPK LVQFIKKGTL SPRKQAQSSK 120
  121 LDEEELQQSS AISEHTPKVN FTITSQQNAD NVQRGLRT

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [159-298]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PTKQILKDAS PIKADLRRQL TFDEVKTKVS RSAKLQELKA VLALKAALEQ KRKEQEERNR  60
   61 KLRDAGPSPS KSKMSVQLKE FDTIELEVLI SPLKTFKTPT KIPPPTPDKH ELMSPRHTDV 120
  121 SKRLLFSPAK NGSPVKLVEV 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [299-580]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PAYKRYASLV ESSRAGQLPL PYKYRHLLDV FKGLDSVVAM FHNRKETITF KKLKPAVQRM  60
   61 LRKNFTETHL AQIKHIYPDA FIFSQVKTRN FGSVSKADYF QLIIAPNVEP LPEQQQSEKP 120
  121 QHFTKINEDD VLASAQSTSM NPHVMTARMQ RFQSLLLDRA MRAHDQFLRS QDPPIIIEKA 180
  181 LTRWHPQFDL ESCPEVELSP LPQPPNVEKY SSAKDILSTA RNLFNCATPM ERAMDRYEAK 240
  241 LESEKQQAAE SNKKTEEQQA GEVTRTSTAI QTSQEVPGIS GS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 13.221849
Match: 1wlqC
Description: Strucure of Geminin-Cdt1 complex
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.29569167054278 bayes_pls_golite062009
DNA binding 4.90756541371868 bayes_pls_golite062009
nucleic acid binding 4.69183445184264 bayes_pls_golite062009
transcription factor activity 4.14166958134441 bayes_pls_golite062009
transcription repressor activity 3.67170893636603 bayes_pls_golite062009
binding 3.52874320222492 bayes_pls_golite062009
sequence-specific DNA binding 2.48053910222825 bayes_pls_golite062009
transcription activator activity 2.29614125067822 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.48055533524841 bayes_pls_golite062009
structure-specific DNA binding 0.913018999939773 bayes_pls_golite062009
transcription factor binding 0.83705247708153 bayes_pls_golite062009
specific transcriptional repressor activity 0.784141484679161 bayes_pls_golite062009
protein binding 0.753698599635855 bayes_pls_golite062009
DNA-dependent ATPase activity 0.697234220778482 bayes_pls_golite062009
DNA helicase activity 0.300899564141452 bayes_pls_golite062009
transcription corepressor activity 0.195360629877364 bayes_pls_golite062009
structural molecule activity 0.111941063082739 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [581-743]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKNPTVPETT NQTETAKPTV KDCTVPDASS NLLKGLPKSL IEKIRAKQAA KALEAMTRRP  60
   61 SQDQEATKYS RLPELARHLR NVFVTERKGV LTLEVIIKKI QNSFRANLTP QEIEAHLKLL 120
  121 AKELPSWASF HEVRKTMYLK VAKDMDMNKI IEKLESVANA KSN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle