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View Structure Prediction Details

Protein: FBpp0303033, Pcl-PA
Organism: Drosophila melanogaster
Length: 1043 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FBpp0303033, Pcl-PA.

Description E-value Query
Range
Subject
Range
gi|54635928, gi|... - gi|54635928|gb|EAL25331.1| GA18665-PA [Drosophila pseudoobscura], gi|125808452|ref|XP_001360756.1| G...
659.0 [0..2] [1040..1]

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Predicted Domain #1
Region A:
Residues: [1-107]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMNNHFHLQH DHPPQNVAHP FMQQPSTAVP SAPPATYGYL AQPAGQQPQW MTTTYQILPP  60
   61 SVGPATVAKR YYATTGPQTT HPTHPSTIQI TNSFAQQSTP PKQQAAT

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [108-178]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SCSPFKANNI RIISTAPSVY SLNKPPQEAH STYAPVQSYY LPSGGGQTAG QINLLAASGT  60
   61 GKQLQPPPLV P

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [179-329]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VTNSTSPPST VVLDRINICI NNHYTETPTS LSSSLTTAQQ PSPIIPAIQH KAILPLIDSS  60
   61 TADSSSCSSS SVSSSSYSGT ATTSAAVVIV DEPDSTTTTP QTPPTTPEAM SSPGKSSPSP 120
  121 PLLATQSLLK GVNSMKPSFK TVEAAPPTPP T

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [330-483]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPSPPPPPPA PPVAAPSPAV TYALQEDVFI KCNDGRFYLG TIIDQTSDQY LIRFDDQSEQ  60
   61 WCEPDKLRKL GGGSSITAGG GGASTTESTN TSPSGPMCVA CKRSDIEDVV EICERCGRGY 120
  121 HRGCTVEIVT GSGIWSCKRC AKPMKMQQPV SHKI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 7.0
Match: 2ysmA
Description: No description for 2ysmA was found.

Predicted Domain #5
Region A:
Residues: [484-581]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TKPAGICRQL PYHADKLSWD EKHRVNEEQI YCYCGKPGKF DHNMLQCCKC RNWFHTQCMQ  60
   61 NFKKKLLRGD MFFVFCCTVC NNGIEFVRRM QIEWVDVL

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.48
Match: 1wepA
Description: Solution structure of PHD domain in PHF8
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 2.84543733401722 bayes_pls_golite062009
binding 2.84147289283175 bayes_pls_golite062009
histone binding 2.70040054044692 bayes_pls_golite062009
DNA binding 2.61461572393763 bayes_pls_golite062009
nucleic acid binding 2.59290953932215 bayes_pls_golite062009
transcription repressor activity 2.05685078783854 bayes_pls_golite062009
transcription factor activity 1.59046392323038 bayes_pls_golite062009
methylated histone residue binding 1.34633512809029 bayes_pls_golite062009
protein binding 1.32925779020231 bayes_pls_golite062009
histone acetyltransferase activity 0.840604267149776 bayes_pls_golite062009
lysine N-acetyltransferase activity 0.840604267149776 bayes_pls_golite062009
transcription activator activity 0.663225694514289 bayes_pls_golite062009
chromatin binding 0.238939737856273 bayes_pls_golite062009
sequence-specific DNA binding 0.0471610688739243 bayes_pls_golite062009
transcription factor binding 0.0293954104210474 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [582-670]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HIALYNLRKH QHQKYHHLLN DIWPFILEQR HQLPICEKWR TLPETALMER LKQTLKDYSD  60
   61 RFVCGREFKR APAFYALRHS GPPHIPKVF

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [671-853]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LEPHEELSDE LLEKRFKLML MPEEPDEGAN ELPKRVPKDV YEFNTDEDDP VETSEDEIPI  60
   61 KQIIEKAKKQ AAQKADKHDE LPLKPDLADD NANDGDPGKL PAPIPPLLDA NSSRKRKAFR 120
  121 LSKRYDNSRN HCDLSSDENS SSSRGTSSLD LIIPPPVNFL GRNNPFLMAT PKKASQGRSI 180
  181 SVG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #8
Region A:
Residues: [854-1043]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TGVGVNGIIN SIFKLKGTSK EQPRMVRTIK RRLSAKDITI GPNQEVRRRR TRRLTTAIEV  60
   61 ISTTTINPIP SHYLPIYAKD LQPPAPPMGK PTHGRLLRQR PQKQSPSQSR RNSTSSTATS 120
  121 SSSNGIGAPG HSMLDLKQSV NKYFGGAMNR IDAGEPFAIR AKRRMGNGQV QYLVEWGGDT 180
  181 ATTAIGLLGN 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle