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View Structure Prediction Details

Protein: FBpp0311815, imd-PA
Organism: Drosophila melanogaster
Length: 273 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FBpp0311815, imd-PA.

Description E-value Query
Range
Subject
Range
gi|34334473, gi|... - gi|34334481|gb|AAQ64727.1| imd [Drosophila simulans], gi|34334479|gb|AAQ64726.1| imd [Drosophila sim...
319.0 [0..1] [267..4]
gi|7264718 - gi|7264718|gb|AAF44326.1|AF222006_1 death-domain containing protein BG5 [Drosophila melanogaster]
311.0 [0..1] [268..27]
gi|34335085 - gi|34335085|gb|AAQ65048.1| imd [Drosophila yakuba]
261.0 [0..1] [220..4]
gi|125809995, gi... - gi|54636489|gb|EAL25892.1| GA18981 [Drosophila pseudoobscura pseudoobscura], gi|125809995|ref|XP_001...
gi|125809995|ref... - GA18981-PA [Drosophila pseudoobscura], GA18981 [Drosophila pseudoobscura pseudoobscura]
255.0 [0..1] [273..1]
gi|31322662 - gi|31322662|gb|AAP41833.1| death domain-containing tumor necrosis factor receptor superfamily member...
179.0 [0..15] [262..188]
RIPK1_MOUSE - Receptor-interacting serine/threonine-protein kinase 1 OS=Mus musculus GN=Ripk1 PE=1 SV=1
177.0 [0..71] [265..479]
gi|3426027, gi|7... - sp|Q13546|RIK1_HUMAN Receptor-interacting serine/threonine-protein kinase 2 (Serine/threonine-protei...
174.0 [0..62] [259..479]
gi|114605235 - gi|114605235|ref|XP_001161105.1| PREDICTED: receptor (TNFRSF)-interacting serine-threonine kinase 1 ...
174.0 [0..62] [259..475]

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Predicted Domain #1
Region A:
Residues: [1-151]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKLRNLLPT IFGGKEAQNP TPVEGRLEKD AAPVDDNEPD NNNSGALALP STAGTPTASS  60
   61 DLTESVLREL SDPNYNSMDV VHSANIPGTL SNVQTNNTMN VHSAQQQVVM NFSNANNLHF 120
  121 GSVYNFNQNL SACSSRKGST STAEESVASP D

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [152-273]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GKPRASATRK TVSIVAMMQS QEEPDVRLLD VVSTHLGEGW KQVMRDLGMS EGQIDQAIID  60
   61 HQMHGNIREV IYQLLLQWIR SSADGVATVG RLTTLLWESQ HRDCVQRMKL VWKALEKRKT 120
  121 NS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 23.522879
Match: 1e3yA
Description: FADD (Mort1)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein binding 3.50518632995622 bayes_pls_golite062009
binding 2.81925838257497 bayes_pls_golite062009
transmembrane receptor activity 0.760464878657872 bayes_pls_golite062009
tumor necrosis factor binding 0.732234543123958 bayes_pls_golite062009
receptor activity 0.669399578675615 bayes_pls_golite062009
death receptor activity 0.627802739213643 bayes_pls_golite062009
tumor necrosis factor receptor activity 0.428938788578756 bayes_pls_golite062009
signal transducer activity 0.216085633642767 bayes_pls_golite062009
molecular transducer activity 0.216085633642767 bayes_pls_golite062009
identical protein binding 0.206123549797411 bayes_pls_golite062009
protein domain specific binding 0.151782936408674 bayes_pls_golite062009
catalytic activity 0.043183590691418 bayes_pls_golite062009

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