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View Structure Prediction Details

Protein: FBpp0309765, robo-PA
Organism: Drosophila melanogaster
Length: 1395 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FBpp0309765, robo-PA.

Description E-value Query
Range
Subject
Range
gi|2804782 - gi|2804782|gb|AAC38849.1| roundabout 1 [Drosophila melanogaster]
853.0 [0..1] [1395..1]

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Predicted Domain #1
Region A:
Residues: [1-152]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHPMHPENHA IARSTSTTNN PSRSRSSRMW LLPAWLLLVL VASNGLPAVR GQYQSPRIIE  60
   61 HPTDLVVKKN EPATLNCKVE GKPEPTIEWF KDGEPVSTNE KKSHRVQFKD GALFFYRTMQ 120
  121 GKKEQDGGEY WCVAKNRVGQ AVSRHASLQI AV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 43.221849
Match: 2v9qA
Description: No description for 2v9qA was found.

Predicted Domain #2
Region A:
Residues: [153-543]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LRDDFRVEPK DTRVAKGETA LLECGPPKGI PEPTLIWIKD GVPLDDLKAM SFGASSRVRI  60
   61 VDGGNLLISN VEPIDEGNYK CIAQNLVGTR ESSYAKLIVQ VKPYFMKEPK DQVMLYGQTA 120
  121 TFHCSVGGDP PPKVLWKKEE GNIPVSRARI LHDEKSLEIS NITPTDEGTY VCEAHNNVGQ 180
  181 ISARASLIVH APPNFTKRPS NKKVGLNGVV QLPCMASGNP PPSVFWTKEG VSTLMFPNSS 240
  241 HGRQHVAADG TLQITDVRQE DEGYYVCSAF SVVDSSTVRV FLQVSSLDER PPPIIQIGPA 300
  301 NQTLPKGSVA TLPCRATGNP SPRIKWFHDG HAVQAGNRYS IIQGSSLRVD DLQLSDSGTY 360
  361 TCTASGERGE TSWAATLTVE KPGSTSLHRA A

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 40.30103
Match: 1bihA
Description: Hemolin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
telethonin binding 6.64811984458494 bayes_pls_golite062009
alpha-actinin binding 5.77350124471385 bayes_pls_golite062009
actinin binding 5.69539760434923 bayes_pls_golite062009
structural constituent of muscle 4.93896503565413 bayes_pls_golite062009
binding 3.17641566810715 bayes_pls_golite062009
receptor activity 2.6260148704617 bayes_pls_golite062009
transmembrane receptor activity 2.26083981067854 bayes_pls_golite062009
molecular transducer activity 2.26075587783872 bayes_pls_golite062009
signal transducer activity 2.26075587783872 bayes_pls_golite062009
protein binding 2.22855404705168 bayes_pls_golite062009
fibroblast growth factor receptor activity 1.8360014271135 bayes_pls_golite062009
fibroblast growth factor 1 binding 1.70428381075539 bayes_pls_golite062009
antigen binding 1.63189745559168 bayes_pls_golite062009
cytoskeletal protein binding 1.58610597245454 bayes_pls_golite062009
actin binding 1.42681407553255 bayes_pls_golite062009
cell adhesion molecule binding 1.36789541796983 bayes_pls_golite062009
protein kinase activity 1.36635494500222 bayes_pls_golite062009
nucleic acid binding 1.32330470851159 bayes_pls_golite062009
DNA binding 1.19412627500732 bayes_pls_golite062009
myosin light chain kinase activity 1.17845072849922 bayes_pls_golite062009
transcription regulator activity 1.16252234499274 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.02286631988334 bayes_pls_golite062009
fibroblast growth factor binding 0.955166176899348 bayes_pls_golite062009
kinase activity 0.929878054374821 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.878595022643164 bayes_pls_golite062009
olfactory receptor activity 0.76374091031142 bayes_pls_golite062009
actin filament binding 0.760856470721016 bayes_pls_golite062009
peptide antigen binding 0.75156669330877 bayes_pls_golite062009
IgG binding 0.68435857661103 bayes_pls_golite062009
myosin heavy chain binding 0.66378995104464 bayes_pls_golite062009
receptor binding 0.632627479346393 bayes_pls_golite062009
titin binding 0.599892148302011 bayes_pls_golite062009
integrin binding 0.599569390248921 bayes_pls_golite062009
structural molecule activity 0.567620977360967 bayes_pls_golite062009
protein serine/threonine kinase activity 0.564762108830441 bayes_pls_golite062009
transcription factor activity 0.54549168007511 bayes_pls_golite062009
G-protein coupled receptor activity 0.51084773288725 bayes_pls_golite062009
protein complex binding 0.43131084085213 bayes_pls_golite062009
protein tyrosine kinase activity 0.318890055375093 bayes_pls_golite062009
transmembrane receptor protein kinase activity 0.310661919610704 bayes_pls_golite062009
structural constituent of cytoskeleton 0.0579247757286607 bayes_pls_golite062009
transferase activity 0.053007146193305 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 0.0182656128082201 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [544-635]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DPSTYPAPPG TPKVLNVSRT SISLRWAKSQ EKPGAVGPII GYTVEYFSPD LQTGWIVAAQ  60
   61 RVGDTQVTIS GLTPGTSYVF LVRAENTQGI SV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 41.39794
Match: 2nziA
Description: No description for 2nziA was found.

Predicted Domain #4
Region A:
Residues: [636-1171]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSGLSNTIKT IEADFDAASA NDLSAARTLL TGKSVELIDA SAINASAVRL EWMLHVSADE  60
   61 KYVEGLRIHY KDASVPSAQY HSITVMDASA ESFVVGNLKK YTKYEFFLTP FFETIEGQPS 120
  121 NSKTALTYED VPSAPPDNIQ IGMYNQTAGW VRWTPPPSQH HNGNLYGYKI EVSAGNTMKV 180
  181 LANMTLNATT TSVLLNNLTT GAVYSVRLNS FTKAGDGPYS KPISLFMDPT HHVHPPRAHP 240
  241 SGTHDGRHEG QDLTYHNNGN IPPGDINPTT HKKTTDYLSG PWLMVLVCIV LLVLVISAAI 300
  301 SMVYFKRKHQ MTKELGHLSV VSDNEITALN INSKESLWID HHRGWRTADT DKDSGLSESK 360
  361 LLSHVNSSQS NYNNSDGGTD YAEVDTRNLT TFYNCRKSPD NPTPYATTMI IGTSSSETCT 420
  421 KTTSISADKD SGTHSPYSDA FAGQVPAVPV VKSNYLQYPV EPINWSEFLP PPPEHPPPSS 480
  481 TYGYAQGSPE SSRKSSKSAG SGISTNQSIL NASIHSSSSG GFSAWGVSPQ YAVACP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.69897
Match: 1zlgA
Description: No description for 1zlgA was found.

Predicted Domain #5
Region A:
Residues: [1172-1269]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PENVYSNPLS AVAGGTQNRY QITPTNQHPP QLPAYFATTG PGGAVPPNHL PFATQRHAAS  60
   61 EYQAGLNAAR CAQSRACNSC DALATPSPMQ PPPPVPVP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [1270-1395]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EGWYQPVHPN SHPMHPTSSN HQIYQCSSEC SDHSRSSQSH KRQLQLEEHG SSAKQRGGHH  60
   61 RRRAPVVQPC MESENENMLA EYEQRQYTSD CCNSSREGDT CSCSEGSCLY AEAGEPAPRQ 120
  121 MTAKNT

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle