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View Structure Prediction Details

Protein: gsb-n-PA
Organism: Drosophila melanogaster
Length: 449 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gsb-n-PA.

Description E-value Query
Range
Subject
Range
gi|2137624, gi|7... - gi|736381|gb|AAA64491.1| Pax7 [Mus musculus], pir||I49265 paired box transcription factor pax7 - mou...
240.0 [0..22] [291..1]

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Predicted Domain #1
Region A:
Residues: [1-175]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDMSSANSLR PLFAGYPFQG QGRVNQLGGV FINGRPLPNH IRLKIVEMAA SGVRPCVISR  60
   61 QLRVSHGCVS KILNRYQETG SIRPGVIGGS KPKVTSPEIE TRIDELRKEN PSIFSWEIRE 120
  121 KLIKEGFADP PSTSSISRLL RGSDRGSEDG RKDYTINGIL GGRDSDISDT ESEPG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 45.30103
Match: 1pdnC
Description: Paired protein (prd)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
transcription repressor activity 3.55154985983449 bayes_pls_golite062009
sequence-specific DNA binding 3.5139760613123 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.16896789933192 bayes_pls_golite062009
transcription activator activity 3.10621734076555 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
protein binding 1.88087411289001 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.73068440195944 bayes_pls_golite062009
chromatin binding 1.68956710349366 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.62096064323298 bayes_pls_golite062009
transcription corepressor activity 1.49423102874486 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
transcription coactivator activity 0.2679415219517 bayes_pls_golite062009
protein deacetylase activity 0.0943601066056998 bayes_pls_golite062009
histone deacetylase activity 0.0802156998596484 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [176-288]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IPLKRKQRRS RTTFTAEQLE ALERAFSRTQ YPDVYTREEL AQTTALTEAR IQVWFSNRRA  60
   61 RLRKHSGGSN SGLSPMNSGS SNVGVGVGLS GATAPLGYGP LGVGSMAGYS PAP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 7.39794
Match: 2cueA
Description: Solution structure of the homeobox domain of the human paired box protein Pax-6
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
transcription repressor activity 3.55154985983449 bayes_pls_golite062009
sequence-specific DNA binding 3.5139760613123 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.16896789933192 bayes_pls_golite062009
transcription activator activity 3.10621734076555 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
protein binding 1.88087411289001 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.73068440195944 bayes_pls_golite062009
chromatin binding 1.68956710349366 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.62096064323298 bayes_pls_golite062009
transcription corepressor activity 1.49423102874486 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
transcription coactivator activity 0.2679415219517 bayes_pls_golite062009
protein deacetylase activity 0.0943601066056998 bayes_pls_golite062009
histone deacetylase activity 0.0802156998596484 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [289-449]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GTTATGAGMN DGVHHAAHAP SSHHSAATAA AAAHHHTQMG GYDLVQSAAQ HGFPGGFAQP  60
   61 GHFGSQNYYH QDYSKLTIDD FSKLTADSVS KISPSLHLSD NYSKLEAPSN WSQAAYHAAA 120
  121 NYNAHVAQHQ LNDYAAAAAH GNPASAYSHP LPTQGQAKYW S

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle