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View Structure Prediction Details

Protein: FBpp0303078, Htr...
Organism: Drosophila melanogaster
Length: 422 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FBpp0303078, Htr....

Description E-value Query
Range
Subject
Range
gi|125775521, gi... - gi|54638711|gb|EAL28113.1| GA21097 [Drosophila pseudoobscura pseudoobscura], gi|125775521|ref|XP_001...
HTRA2_DROPS - Serine protease HTRA2, mitochondrial OS=Drosophila pseudoobscura pseudoobscura GN=HtrA2 PE=3 SV=1
294.0 [0..1] [422..1]

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Predicted Domain #1
Region A:
Residues: [1-86]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALRGSHRLE VIFKRCIASP VLHSHAANRR SSQLAIKEGD PNSNGNSGQY QQNGEQKEKG  60
   61 WRRLVRFFVP FSLGAVVSAA IIQRED

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [87-422]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTPTIAASKM TGRRRDFNFI ADVVAGCADS VVYIEIKDTR HFDYFSGQPI TASNGSGFII  60
   61 EQNGLILTNA HVVINKPHTM VQVRLSDGRT FPATIEDVDQ TSDLATLRIQ VNNLSVMRLG 120
  121 KSSTLRSGEW VVALGSPLAL SNTVTAGVIS STQRASQELG LRNRDINYLQ TDAAITFGNS 180
  181 GGPLVNLDGE AIGVNSMKVT AGISFAIPID YVKVFLERAA EKRKKGSAYK TGYPVKRYMG 240
  241 ITMLTLTPDI LFELKSRSQN MPSNLTHGVL VWKVIVGSPA HSGGLQPGDI VTHINKKEIK 300
  301 NSSDVYDALA DNSKTLDIVI LRGVKQMHVT ITPEDP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 51.522879
Match: 1lcyA
Description: Mitochondrial serine protease HtrA2; Mitochondrial serine protease HtrA2, catalytic domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity 5.28251016030465 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 4.93232564230667 bayes_pls_golite062009
endopeptidase activity 4.76863192965644 bayes_pls_golite062009
hydrolase activity 4.7420645083083 bayes_pls_golite062009
serine hydrolase activity 3.40985043278892 bayes_pls_golite062009
serine-type peptidase activity 3.40724860044542 bayes_pls_golite062009
serine-type endopeptidase activity 3.13486560415684 bayes_pls_golite062009
catalytic activity 1.40927913545237 bayes_pls_golite062009
protein binding 0.0013332686405948 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle