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View Structure Prediction Details

Protein: loco-PB
Organism: Drosophila melanogaster
Length: 1175 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for loco-PB.

Description E-value Query
Range
Subject
Range
gi|4581016 - gi|4581016|gb|AAD24580.1|AF130744_1 regulator of G-protein signalling LOCO C2 [Drosophila melanogast...
1080.0 [0..1] [1175..1]

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Predicted Domain #1
Region A:
Residues: [1-190]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNNTNTTRGT CSRIPIASKQ EPTIASMVER FVQSLSQLND SGTFDSSFEI KRIHPGSSAG  60
   61 STPKHVRHRC LTELDREQLT RFVQDFEERQ ASTPKVKSKI SSPYICRKAK EFYQSASGRR 120
  121 SASPQITIAP ETVQEEKVLV NPLPRKCAEA EDLMPPPMAM ARVQAERRSC RSASRVLQFF 180
  181 SSATKRRSGN 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [191-396]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RKLSEPEMED NRADSPVLIR VTRDRVEEQL GCSPLAASGG EVPTSSEDEE EHDDGISSAS  60
   61 SNLTSQSGSS NSRNLSPDSS FEMHAPLLPS FKVTPPRAVC RVGKNAACEF ARFLRGSFHS 120
  121 KRASVTTLRR SLSDPDAVQQ MDFSKPPPLR DTTNVMRNRA LPANASPFRR AWGQSSFRTP 180
  181 RSDKVAKEQQ QLGQSSPVRR TASMNA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [397-600]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SDNDMYIKTL MLDSDLKSSR SQHQLSLLQV PKVLTTPAPP SAITASVAAE GAAQDHGCPS  60
   61 SWAGSFERML QDAAGMQTFS EFLKKEFSAE NIYFWTACER YRLLESEADR VAQAREIFAK 120
  121 HLANNSSDPV NVDSQARSLT EEKLADAAPD IFAPAQKQIF SLMKFDSYQR FIRSDLYKSC 180
  181 VEAEQKNQPL PYSGLDLDEL LKTN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 56.69897
Match: 1agrE
Description: Regulator of G-protein signalling 4, RGS4
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
GTPase regulator activity 1.92987277493861 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 1.90800479999702 bayes_pls_golite062009
GTPase activator activity 1.87534424848905 bayes_pls_golite062009
binding 1.71250041369331 bayes_pls_golite062009
enzyme activator activity 1.62073651679221 bayes_pls_golite062009
enzyme regulator activity 1.49796137854909 bayes_pls_golite062009
protein binding 1.34804002381061 bayes_pls_golite062009
signal transducer activity 1.14361809679544 bayes_pls_golite062009
molecular transducer activity 1.14361809679544 bayes_pls_golite062009
beta-catenin binding 0.59248827140739 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [601-690]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FHLGAFSKLK KSASNAEDRR RKSLLPWHRK TRSKSRDRTE IMADMQHALM PAPPVPQNAP  60
   61 LTSASLKLVC GQNSLSDLHS SRSSLSSFDA 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [691-779]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GTATGGQGAS TESVYSLCRV ILTDGATTIV QTRPGETVGE LVERLLEKRN LVYPYYDIVF  60
   61 QGSTKSIDVQ QPSQILAGKE VVIERRVAF

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.7
Match: 1rrbA
Description: THE RAS-BINDING DOMAIN OF RAF-1 FROM RAT, NMR, 1 STRUCTURE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cytoskeletal protein binding 3.28306198153429 bayes_pls_golite062009
binding 2.0688320293797 bayes_pls_golite062009
protein binding 1.72968950672856 bayes_pls_golite062009
signal transducer activity 1.07208466109379 bayes_pls_golite062009
molecular transducer activity 1.07208466109379 bayes_pls_golite062009
receptor binding 0.286966350616338 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [780-881]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KLDLPDPKVI SVKSKPKKQL HEVIRPILSK YNYKMEQVQV IMRDTQVPID LNQPVTMADG  60
   61 QRLRIVMVNS DFQVGGGSSM PPKQSKPMKP LPQGHLDELT NK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.69897
Match: 1wfyA
Description: Solution structure of the Ras-binding domain of mouse RGS14
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cytoskeletal protein binding 3.3713276381973 bayes_pls_golite062009
binding 2.14676646738549 bayes_pls_golite062009
protein binding 1.86841453215444 bayes_pls_golite062009
signal transducer activity 1.05682194741929 bayes_pls_golite062009
molecular transducer activity 1.05682194741929 bayes_pls_golite062009
receptor binding 0.298046142314417 bayes_pls_golite062009

Predicted Domain #7
Region A:
Residues: [882-1082]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VFNELLASKA DAAASEKSRP VDLCSMKSNE APSETSSLFE RMRRQQRDGG NIPASKLPKL  60
   61 KKKSTSSSQQ SEEAATTQAV ADPKKPIIAK LKAGVKLQVT ERVAEHQDEL LEGLKRAQLA 120
  121 RLEDQRGTEI NFDLPDFLKN KENLSAAVSK LRKVRASLSP VSKVPATPTE IPQPAPRLSI 180
  181 TRSQQPVSPM KVDQEPETDL P

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 13.522879
Match: 1i3qA
Description: RBP1
Matching Structure (courtesy of the PDB):

Predicted Domain #8
Region A:
Residues: [1083-1175]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AATQDQTEFA KAPPPLPPKP KVLPIKPSNW GVAQPTGNYC NKYSPSKQVP TSPKEASKPG  60
   61 TFASKIPLDL GRKSLEEAGS RCAYLDEPSS SFV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.09691
Match: 1deqA
Description: Fibrinogen
Matching Structure (courtesy of the PDB):

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