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View Structure Prediction Details

Protein: Dcr-1-PA
Organism: Drosophila melanogaster
Length: 2249 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Dcr-1-PA.

Description E-value Query
Range		 Subject
Range
gi|125773725, gi... - gi|54637856|gb|EAL27258.1| GA18437 [Drosophila pseudoobscura pseudoobscura], gi|125773725|ref|XP_001...
gi|125773725|ref... - GA18437-PA [Drosophila pseudoobscura], GA18437 [Drosophila pseudoobscura pseudoobscura]
 1636.0 [0..1] [2249..1]

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Predicted Domain #1
Region A:
Residues: [1-375] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAFHWCDNNL HTTVFTPRDF QVELLATAYE RNTIICLGHR SSKEFIALKL LQELSRRARR  60
   61 HGRVSVYLSC EVGTSTEPCS IYTMLTHLTD LRVWQEQPDM QIPFDHCWTD YHVSILRPEG 120
  121 FLYLLETREL LLSSVELIVL EDCHDSAVYQ RIRPLFENHI MPAPPADRPR ILGLAGPLHS 180
  181 AGCELQQLSA MLATLEQSVL CQIETASDIV TVLRYCSRPH EYIVQCAPFE MDELSLVLAD 240
  241 VLNTHKSFLL DHRYDPYEIY GTDQFMDELK DIPDPKVDPL NVINSLLVVL HEMGPWCTQR 300
  301 AAHHFYQCNE KLKVKTPHER HYLLYCLVST ALIQLYSLCE HAFHRHLGSG SDSRQTIERY 360
  361 SSPKVRRLLQ TLRCF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 69.39794
Match: 2j0qA
Description: No description for 2j0qA was found.

Predicted functions:

Term Confidence Notes
nucleoside-triphosphatase activity 2.85628130885095 bayes_pls_golite062009
pyrophosphatase activity 2.78950165917982 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 2.76996223962376 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.7670079419026 bayes_pls_golite062009
binding 2.64537357529343 bayes_pls_golite062009
transporter activity 2.36978240084485 bayes_pls_golite062009
ATPase activity 2.26864012421561 bayes_pls_golite062009
transmembrane transporter activity 2.18065576425044 bayes_pls_golite062009
nucleic acid binding 2.11222585187695 bayes_pls_golite062009
ATPase activity, coupled 2.07184330056272 bayes_pls_golite062009
RNA helicase activity 1.8459294302596 bayes_pls_golite062009
DNA binding 1.72568209621547 bayes_pls_golite062009
transcription regulator activity 1.63193306273479 bayes_pls_golite062009
RNA binding 1.60613159109369 bayes_pls_golite062009
structural constituent of ribosome 1.57653963868443 bayes_pls_golite062009
hydrolase activity 1.44476395406467 bayes_pls_golite062009
1.44426272235796 bayes_pls_golite062009
substrate-specific transporter activity 1.09373202836575 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
purine nucleotide binding 0.929901285538132 bayes_pls_golite062009
nucleotide binding 0.922442819194247 bayes_pls_golite062009
purine ribonucleotide binding 0.920987930180051 bayes_pls_golite062009
ribonucleotide binding 0.920926158369519 bayes_pls_golite062009
RNA-dependent ATPase activity 0.74918137191219 bayes_pls_golite062009
transcription repressor activity 0.720765886383727 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.696000326143746 bayes_pls_golite062009
ATP-dependent RNA helicase activity 0.69117331267457 bayes_pls_golite062009
microtubule motor activity 0.61802593501 bayes_pls_golite062009
structural molecule activity 0.596382945962261 bayes_pls_golite062009
transcription factor activity 0.567932466447757 bayes_pls_golite062009
GTPase activity 0.564061217246417 bayes_pls_golite062009
active transmembrane transporter activity 0.434775387083003 bayes_pls_golite062009
ATP binding 0.41092997612902 bayes_pls_golite062009
adenyl ribonucleotide binding 0.385813421701492 bayes_pls_golite062009
adenyl nucleotide binding 0.377870145186619 bayes_pls_golite062009
guanyl nucleotide binding 0.296406132096546 bayes_pls_golite062009
GTP binding 0.295705904888768 bayes_pls_golite062009
primary active transmembrane transporter activity 0.294474570607914 bayes_pls_golite062009
guanyl ribonucleotide binding 0.29028316917561 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 0.282352478532746 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 0.220608508617331 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 0.219533217661421 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 0.219157471322311 bayes_pls_golite062009
protein binding 0.170837278876362 bayes_pls_golite062009
ion transmembrane transporter activity 0.140475613064199 bayes_pls_golite062009
structure-specific DNA binding 0.0869561319004262 bayes_pls_golite062009
helicase activity 0.0775311459068899 bayes_pls_golite062009
signal sequence binding 6.53725193420218E-4 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [376-458] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KPEEVHTQAD GLRRMRHQVD QADFNRLSHT LESKCRMVDQ MDQPPTETRA LVATLEQILH  60
   61 TTEDRQTNRS AARVTPTPTP AHA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [459-814] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KPKPSSGANT AQPRTRRRVY TRRHHRDHND GSDTLCALIY CNQNHTARVL FELLAEISRR  60
   61 DPDLKFLRCQ YTTDRVADPT TEPKEAELEH RRQEEVLKRF RMHDCNVLIG TSVLEEGIDV 120
  121 PKCNLVVRWD PPTTYRSYVQ CKGRARAAPA YHVILVAPSY KSPTVGSVQL TDRSHRYICA 180
  181 TGDTTEADSD SDDSAMPNSS GSDPYTFGTA RGTVKILNPE VFSKQPPTAC DIKLQEIQDE 240
  241 LPAAAQLDTS NSSDEAVSMS NTSPSESSTE QKSRRFQCEL SSLTEPEDTS DTTAEIDTAH 300
  301 SLASTTKDLV HQMAQYREIE QMLLSKCANT EPPEQEQSEA ERFSACLAAY RPKPHL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.69897
Match: 1c4oA
Description: Nucleotide excision repair enzyme UvrB
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nucleoside-triphosphatase activity 2.85628130885095 bayes_pls_golite062009
pyrophosphatase activity 2.78950165917982 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 2.76996223962376 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.7670079419026 bayes_pls_golite062009
binding 2.64537357529343 bayes_pls_golite062009
transporter activity 2.36978240084485 bayes_pls_golite062009
ATPase activity 2.26864012421561 bayes_pls_golite062009
transmembrane transporter activity 2.18065576425044 bayes_pls_golite062009
nucleic acid binding 2.11222585187695 bayes_pls_golite062009
ATPase activity, coupled 2.07184330056272 bayes_pls_golite062009
RNA helicase activity 1.8459294302596 bayes_pls_golite062009
DNA binding 1.72568209621547 bayes_pls_golite062009
transcription regulator activity 1.63193306273479 bayes_pls_golite062009
RNA binding 1.60613159109369 bayes_pls_golite062009
structural constituent of ribosome 1.57653963868443 bayes_pls_golite062009
hydrolase activity 1.44476395406467 bayes_pls_golite062009
1.44426272235796 bayes_pls_golite062009
substrate-specific transporter activity 1.09373202836575 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
purine nucleotide binding 0.929901285538132 bayes_pls_golite062009
nucleotide binding 0.922442819194247 bayes_pls_golite062009
purine ribonucleotide binding 0.920987930180051 bayes_pls_golite062009
ribonucleotide binding 0.920926158369519 bayes_pls_golite062009
RNA-dependent ATPase activity 0.74918137191219 bayes_pls_golite062009
transcription repressor activity 0.720765886383727 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.696000326143746 bayes_pls_golite062009
ATP-dependent RNA helicase activity 0.69117331267457 bayes_pls_golite062009
microtubule motor activity 0.61802593501 bayes_pls_golite062009
structural molecule activity 0.596382945962261 bayes_pls_golite062009
transcription factor activity 0.567932466447757 bayes_pls_golite062009
GTPase activity 0.564061217246417 bayes_pls_golite062009
active transmembrane transporter activity 0.434775387083003 bayes_pls_golite062009
ATP binding 0.41092997612902 bayes_pls_golite062009
adenyl ribonucleotide binding 0.385813421701492 bayes_pls_golite062009
adenyl nucleotide binding 0.377870145186619 bayes_pls_golite062009
guanyl nucleotide binding 0.296406132096546 bayes_pls_golite062009
GTP binding 0.295705904888768 bayes_pls_golite062009
primary active transmembrane transporter activity 0.294474570607914 bayes_pls_golite062009
guanyl ribonucleotide binding 0.29028316917561 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 0.282352478532746 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 0.220608508617331 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 0.219533217661421 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 0.219157471322311 bayes_pls_golite062009
protein binding 0.170837278876362 bayes_pls_golite062009
ion transmembrane transporter activity 0.140475613064199 bayes_pls_golite062009
structure-specific DNA binding 0.0869561319004262 bayes_pls_golite062009
helicase activity 0.0775311459068899 bayes_pls_golite062009
signal sequence binding 6.53725193420218E-4 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [815-983] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTGASVDLGS AIALVNKYCA RLPSDTFTKL TALWRCTRNE RAGVTLFQYT LRLPINSPLK  60
   61 HDIVGLPMPT QTLARRLAAL QACVELHRIG ELDDQLQPIG KEGFRALEPD WECFELEPED 120
  121 EQIVQLSDEP RPGTTKRRQY YYKRIASEFC DCRPVAGAPC YLYFIQLTL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [984-1706] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QCPIPEEQNT RGRKIYPPED AQQGFGILTT KRIPKLSAFS IFTRSGEVKV SLELAKERVI  60
   61 LTSEQIVCIN GFLNYTFTNV LRLQKFLMLF DPDSTENCVF IVPTVKAPAG GKHIDWQFLE 120
  121 LIQANGNTMP RAVPDEERQA QPFDPQRFQD AVVMPWYRNQ DQPQYFYVAE ICPHLSPLSC 180
  181 FPGDNYRTFK HYYLVKYGLT IQNTSQPLLD VDHTSARLNF LTPRYVNRKG VALPTSSEET 240
  241 KRAKRENLEQ KQILVPELCT VHPFPASLWR TAVCLPCILY RINGLLLADD IRKQVSADLG 300
  301 LGRQQIEDED FEWPMLDFGW SLSEVLKKSR ESKQKESLKD DTINGKDLAD VEKKPTSEET 360
  361 QLDKDSKDDK VEKSAIELII EGEEKLQEAD DFIEIGTWSN DMADDIASFN QEDDDEDDAF 420
  421 HLPVLPANVK FCDQQTRYGS PTFWDVSNGE SGFKGPKSSQ NKQGGKGKAK GPAKPTFNYY 480
  481 DSDNSLGSSY DDDDNAGPLN YMHHNYSSDD DDVADDIDAG RIAFTSKNEA ETIETAQEVE 540
  541 KRQKQLSIIQ ATNANERQYQ QTKNLLIGFN FKHEDQKEPA TIRYEESIAK LKTEIESGGM 600
  601 LVPHDQQLVL KRSDAAEAQV AKVSMMELLK QLLPYVNEDV LAKKLGDRRE LLLSDLVELN 660
  661 ADWVARHEQE TYNVMGCGDS FDNYNDHHRL NLDEKQLKLQ YERIEIEPPT STKAITSAIL 720
  721 PAG

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.1
Match: 2fflA
Description: Crystal Structure of Dicer from Giardia intestinalis
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [1707-1935] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FSFDRQPDLV GHPGPSPSII LQALTMSNAN DGINLERLET IGDSFLKYAI TTYLYITYEN  60
   61 VHEGKLSHLR SKQVANLNLY RLGRRKRLGE YMIATKFEPH DNWLPPCYYV PKELEKALIE 120
  121 AKIPTHHWKL ADLLDIKNLS SVQICEMVRE KADALGLEQN GGAQNGQLDD SNDSCNDFSC 180
  181 FIPYNLVSQH SIPDKSIADC VEALIGAYLI ECGPRGALLF MAWLGVRVL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 57.69897
Match: 1o0wA
Description: RNase III endonuclease catalytic domain; RNase III, C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
bidentate ribonuclease III activity 7.43273509253496 bayes_pls_golite062009
RNA binding 5.07736605479017 bayes_pls_golite062009
nucleic acid binding 3.65107032334139 bayes_pls_golite062009
binding 3.29553298371996 bayes_pls_golite062009
siRNA binding 2.97216972787792 bayes_pls_golite062009
structural constituent of ribosome 2.92231310035944 bayes_pls_golite062009
structural molecule activity 2.39325095233158 bayes_pls_golite062009
ribonuclease III activity 2.17541496872253 bayes_pls_golite062009
DNA binding 2.1200214740272 bayes_pls_golite062009
transcription regulator activity 1.90221544752436 bayes_pls_golite062009
transcription repressor activity 1.67466835456592 bayes_pls_golite062009
endoribonuclease activity 1.62086478301433 bayes_pls_golite062009
protein binding 1.43319050998069 bayes_pls_golite062009
double-stranded RNA binding 0.967560318725736 bayes_pls_golite062009
transcription factor activity 0.94870998048449 bayes_pls_golite062009
mRNA binding 0.404665180963566 bayes_pls_golite062009
single-stranded RNA binding 0.35650576095599 bayes_pls_golite062009
transcription activator activity 0.270384165279764 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.0407924801791524 bayes_pls_golite062009
pyrophosphatase activity 0.0126548515995795 bayes_pls_golite062009
RNA helicase activity 0.0112094156505713 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.00332337214730594 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 9.75560608640569E-4 bayes_pls_golite062009

Predicted Domain #7
Region A:
Residues: [1936-2168] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PITRQLDGGN QEQRIPGSTK PNAENVVTVY GAWPTPRSPL LHFAPNATEE LDQLLSGFEE  60
   61 FEESLGYKFR DRSYLLQAMT HASYTPNRLT DCYQRLEFLG DAVLDYLITR HLYEDPRQHS 120
  121 PGALTDLRSA LVNNTIFASL AVRHGFHKFF RHLSPGLNDV IDRFVRIQQE NGHCISEEYY 180
  181 LLSEEECDDA EDVEVPKALG DVFESIAGAI FLDSNMSLDV VWHVYSNMMS PEI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 31.39794
Match: 1jfzA
Description: RNase III endonuclease catalytic domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ribonuclease III activity 7.98215035226939 bayes_pls_golite062009
bidentate ribonuclease III activity 7.43273509253496 bayes_pls_golite062009
endoribonuclease activity, producing 5'-phosphomonoesters 3.62034457906124 bayes_pls_golite062009
endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 3.472019089204 bayes_pls_golite062009
RNA binding 3.13107297902467 bayes_pls_golite062009
ribonuclease activity 2.98742815985809 bayes_pls_golite062009
nuclease activity 2.45414735688985 bayes_pls_golite062009
endonuclease activity 2.36392815890913 bayes_pls_golite062009
nucleic acid binding 2.01588157313998 bayes_pls_golite062009
binding 1.78270819466471 bayes_pls_golite062009
endoribonuclease activity 1.62086478301433 bayes_pls_golite062009
hydrolase activity 1.55049982171696 bayes_pls_golite062009
catalytic activity 1.11705147289713 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 0.956576570132238 bayes_pls_golite062009
protein binding 0.411168252280077 bayes_pls_golite062009

Predicted Domain #8
Region A:
Residues: [2169-2249] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EQFSNSVPKS PIRELLELEP ETAKFGKPEK LADGRRVRVT VDVFCKGTFR GIGRNYRIAK  60
   61 CTAAKCALRQ LKKQGLIAKK D

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.045757
Match: 2yt4A
Description: No description for 2yt4A was found.
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle