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View Structure Prediction Details

Protein: orb-PE, orb-PC
Organism: Drosophila melanogaster
Length: 559 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for orb-PE, orb-PC.

Description E-value Query
Range
Subject
Range
gi|73976803 - gi|73976803|ref|XP_857821.1| PREDICTED: similar to poly(A) binding protein, cytoplasmic 4 isoform 2 ...
374.0 [0..34] [556..11]

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Predicted Domain #1
Region A:
Residues: [1-208]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAKVLRVNLL SVNSNKIPHQ QQQQQQQQQQ QQQQQQQNQQ QLQVQQQHQL QQQFVNLNRN  60
   61 YEQQISANLG SQQHGFEHNG VGVGASSSGN ENCFSQYNLE NITSVDMELA KLQNLQRINT 120
  121 LKLLHAQAQQ MPLINQLLQS YAGNAIGSVG GSNLGNLMSA GGSSLMTEMA GNVGGIITTN 180
  181 DGHLDRVAKF YKSSAALCDA TCTWSGHL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 35.69897
Match: 1cvjA
Description: Poly(A)-binding protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 4.63987691433124 bayes_pls_golite062009
nucleic acid binding 3.64594243387558 bayes_pls_golite062009
mRNA binding 3.54495985180603 bayes_pls_golite062009
binding 3.00411894202318 bayes_pls_golite062009
protein binding 2.17260848225967 bayes_pls_golite062009
1.71820051628117 bayes_pls_golite062009
single-stranded RNA binding 1.46469774223879 bayes_pls_golite062009
poly-pyrimidine tract binding 0.862661444935922 bayes_pls_golite062009
transcription regulator activity 0.737458867828906 bayes_pls_golite062009
DNA binding 0.691258294213766 bayes_pls_golite062009
mRNA 3'-UTR binding 0.599389001184667 bayes_pls_golite062009
translation regulator activity 0.38120065819101 bayes_pls_golite062009
sequence-specific DNA binding 0.366758605553422 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.128616879457381 bayes_pls_golite062009
transcription activator activity 0.119266921032347 bayes_pls_golite062009
structural molecule activity 0.0829058000493267 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [209-416]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPRSHRMLNY SPKVFLGGIP WDISEQSLIQ IFKPFGSIKV EWPGKEQQAA QPKGYVYIIF  60
   61 ESDKQVKALL SACVLQVDDS HCGRNYFFKI SSRRIKSKDV EVIPWIIADS NFVRSSSQKL 120
  121 DPTKTVFVGA LHGKLTAEGL GNIMDDLFDG VLYAGIDTDK YKYPIGSGRV TFSNFRSYMK 180
  181 AVSAAFIEIR TTKFTKKVQV DPYLEDAL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 42.522879
Match: 1pgzA
Description: Crystal Structure of UP1 Complexed With d(TTAGGGTTAG(6-MI)G); A Human Telomeric Repeat Containing 6-methyl-8-(2-deoxy-beta-ribofuranosyl)isoxanthopteridine (6-MI)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 4.63987691433124 bayes_pls_golite062009
nucleic acid binding 3.64594243387558 bayes_pls_golite062009
mRNA binding 3.54495985180603 bayes_pls_golite062009
binding 3.00411894202318 bayes_pls_golite062009
protein binding 2.17260848225967 bayes_pls_golite062009
1.71820051628117 bayes_pls_golite062009
single-stranded RNA binding 1.46469774223879 bayes_pls_golite062009
poly-pyrimidine tract binding 0.862661444935922 bayes_pls_golite062009
transcription regulator activity 0.737458867828906 bayes_pls_golite062009
DNA binding 0.691258294213766 bayes_pls_golite062009
mRNA 3'-UTR binding 0.599389001184667 bayes_pls_golite062009
translation regulator activity 0.38120065819101 bayes_pls_golite062009
sequence-specific DNA binding 0.366758605553422 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.128616879457381 bayes_pls_golite062009
transcription activator activity 0.119266921032347 bayes_pls_golite062009
structural molecule activity 0.0829058000493267 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [417-559]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CSICGVQHGP YYCRELSCFR YFCRSCWQWQ HSCDIVKNHK PLTRNSKSQS LVGIGPSSSN  60
   61 VSLPFSGQRS IRDNRMGNGQ HQQHQQHQYQ QQKHRQLQEY SQPHSLNVMG NSGAANAAAT 120
  121 SMVTLQQRQI HKVRIQRQQH QAI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.045757
Match: 1m2vB
Description: Sec24
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle