| Protein: | CG10260-PB |
| Organism: | Drosophila melanogaster |
| Length: | 2178 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CG10260-PB.
| Description | E-value | Query Range |
Subject Range |
|
|
2487.0 | [0..1] | [2178..1] |
|
Region A: Residues: [1-84] |
1 11 21 31 41 51
| | | | | |
1 MTMTASDKYT YQRTVLCLAR VLAGIQPTPW DKVHVHLATH STSHSASPPG NRLFALTLSG 60
61 GHKTDMRGRS GGGGKAVQTL FRYC
|
| Detection Method: |  |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [85-255] |
1 11 21 31 41 51
| | | | | |
1 PQENAAGVFC LDTRAQDAVI ALGIYFLEGG CQHEGQIVPY LLRLAKCLPK AVWIDDARSN 60
61 KVERVRIPSA EKFSFCLNTL LSDIAAKCPD SREEIILNQV ETLSALANIV KSSRDSSSAP 120
121 PPIILCKATV PLLFGLARSM GRYASNDPPL LCRIFPPELL PIQKGGGRDG T
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [256-342] |
1 11 21 31 41 51
| | | | | |
1 GSSSSASGTC GGSFSSSERL AATHHFRPII PRSMSGSLAQ AQNASYDDGR QRCAGGKPSK 60
61 PSLHSYFSVP YDPRTHFFTR YGSSFNQ
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [343-431] |
1 11 21 31 41 51
| | | | | |
1 FPNMRVCESP TKGGPRPLYR VPPFPIQHLQ TIFAVSKKLL TKDTLEHLDE QASDIFSLHQ 60
61 IKGYCYKSFS ETLNLVLVTL LRELLQHQV
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [432-502] |
1 11 21 31 41 51
| | | | | |
1 DLPTPFTKDV QEFVKRLFLN GQTELQNKQQ DQERERREEN GIAVVNKYKV NVMANAACVD 60
61 LLVWAIRDET E
|
| Detection Method: | |
Shown below is our most confident prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [503-820] |
1 11 21 31 41 51
| | | | | |
1 ADKLCGRLSQ KLNLELSHKI VMDHMPLLMV CLEGLGKLAH KFPNIAGTSI SYLRDFLVAP 60
61 SPILGKLHDH AMQSLAQQKK EKELTPFKIA VQHSDSRTAV VIYGDNQKPP GSGTGRSGHA 120
121 AFESLRDAAI ENLSIALRAA HTLDQFCVPA LVANVSNRLF TAEKSGSESQ GECHKSNLVS 180
181 LNIIVMLGHV AVALKDTSKT TQNILQFFIQ RFCKVPSEQN ALIVDQLGCM IISQCETHVF 240
241 DEIMKMFSRV TVQSASLAYT SDPEHRKQFH HVSDAVVNAL GNIAANIQGD AEMLELLGKL 300
301 LELFVQIGLD GERSYDNT
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [821-897] |
1 11 21 31 41 51
| | | | | |
1 PGAQKASSRA GNLGMLIPVI AVLVRRLPPI KNPRQRLHKL FKDFWAYCVV MGFTNARLWP 60
61 ADWYQGVQQI AAKSPLL
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [898-987] |
1 11 21 31 41 51
| | | | | |
1 ISQTAHKSDM RELNYTLAIK SDSVNELRSQ ILVLLEHSSD NVATAINKLS FAQCTYLLSV 60
61 YWLEMLRVEN ADEPSLEPIM SYLCDTALQR
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [988-1163] |
1 11 21 31 41 51
| | | | | |
1 DKTGIWQCVK CVADQVFEKF RNVLYAHDEI REKVLESQAT LLLVYFNHIH KPIQMVADQY 60
61 LSFLVDRFPH LLWNRRVLWC MLDILQLLAY SLSLDPNEET PTLRVVSTPY TLQLMDSLPA 120
121 RELRLKDFAD RCQGIVNEAM KWAPRSTRSH LQEYPNQIPT PVLAHHSGLA LAFDSV
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [1164-1431] |
1 11 21 31 41 51
| | | | | |
1 VSSSAQHTGT MSKRPSCVNS DTPRFVSVLC LRSKYAGEIS GLLSVLSEKD KAGLADRLVS 60
61 DVWEACAEKS DARHRGALWR ATAYLIICSE ISRKLLHAVA SSQLELFTES AMETAVECWQ 120
121 WVLTARQDLE LCFIQEMVSA WQTTFEKRMG LFAWETEVTH PLAAYEGCKL VSKPILIAPH 180
181 LIWLQLLSEM VDTAKYCNRD KVEMFCLLLH RCLPVLKSSK QNRQVSTVGC RFKLLQCGLS 240
241 LLQGNTIPKS LSRNILRERI YSNALDYF
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [1432-2178] |
1 11 21 31 41 51
| | | | | |
1 CGPPTCPNQS REQLLEDIMI LLKFWQTMRS EKKHLVTSEV GDYDLTNASV SSTQMLAVRN 60
61 NPETASLISG GGLVNDYTRS MSASGNAVGM GMGVAGGGSS SGWYNTIPHS TSTLSKRSNR 120
121 SKRLQYQKDS YDKDYMKKRN LILELLAVEL EFLITWYNPN SLPDLIVPGE EQITEWRNRP 180
181 YKSTVWRDYA RLAWCYNPAL AVFLPQRIKN AEIIDEEVSR LVCSDPIAVC HIPEALKYLC 240
241 TTKNLLQESP DLVYILSWSP VTPIQALAYF SRQYPSHPLT AQYAVKTLSS YPAESVLPYI 300
301 PQLVQALRHD TMGYVVEFIK NISRRSQIVA HQLIWNMQTN MYMDEDQQHK DPNLYEALDQ 360
361 LSQSIIASFS GAAKRFYERE FDFFGKITAV SGEIRSFAKG IERKNACLAA LSRIKVQGGC 420
421 YLPSNPEAMV LDIDYSSGTP MQSAAKAPYL ARFRVYRCGI TELETRAMEV SNNPNSQEDA 480
481 KMTLGVESWQ AAIFKVGDDV RQDMLALQVI TIFKNIFQQV GLDLFLFPYR VVATAPGCGV 540
541 IECVPNAKSR DQLGRQTDSG LSEYFQHQYG DESSKEFQAA RANFVKSMAA YSLIGYLLQI 600
601 KDRHNGNIMI DKDGHIIHID FGFMFESSPG GNIGFEPDMK LTDEMVMIMG GKMDSPAFKW 660
661 FCELCVQAFL AVRPYQDAIV SLVSLMLDTG LPCFRGQTIN LLKQRFVATK NNKEAAAHML 720
721 AVIRNSYQNF RTRTYDMIQY YQNQIPY
|
| Detection Method: | |
| Confidence: | 125.0 |
| Match: | 1e7uA |
| Description: | Phoshoinositide 3-kinase (PI3K) helical domain; Phoshoinositide 3-kinase (PI3K); Phoshoinositide 3-kinase (PI3K), catalytic domain |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| protein kinase activity | 4.39461982655248 | bayes_pls_golite062009 |
| phosphotransferase activity, alcohol group as acceptor | 4.32184067232044 | bayes_pls_golite062009 |
| kinase activity | 4.16135267871365 | bayes_pls_golite062009 |
| protein serine/threonine kinase activity | 3.92556971928915 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 3.76541923765309 | bayes_pls_golite062009 |
| transferase activity | 2.57136779276375 | bayes_pls_golite062009 |
| binding | 2.31930216202447 | bayes_pls_golite062009 |
| calcium-dependent phospholipid binding | 2.27288137663828 | bayes_pls_golite062009 |
| protein tyrosine kinase activity | 2.0371109148587 | bayes_pls_golite062009 |
| molecular transducer activity | 1.95775692939268 | bayes_pls_golite062009 |
| signal transducer activity | 1.95775692939268 | bayes_pls_golite062009 |
| ATP binding | 1.62950013799854 | bayes_pls_golite062009 |
| adenyl ribonucleotide binding | 1.59120412984243 | bayes_pls_golite062009 |
| adenyl nucleotide binding | 1.57251948653832 | bayes_pls_golite062009 |
| ribonucleotide binding | 1.32931505255952 | bayes_pls_golite062009 |
| purine ribonucleotide binding | 1.32676572752438 | bayes_pls_golite062009 |
| purine nucleotide binding | 1.31489723493061 | bayes_pls_golite062009 |
| receptor signaling protein activity | 1.3145826655017 | bayes_pls_golite062009 |
| nucleotide binding | 1.31339663939554 | bayes_pls_golite062009 |
| transmembrane receptor activity | 1.27941426224024 | bayes_pls_golite062009 |
| transmembrane receptor protein kinase activity | 1.27740808551012 | bayes_pls_golite062009 |
| protein binding | 1.22565748038754 | bayes_pls_golite062009 |
| catalytic activity | 1.21655087018101 | bayes_pls_golite062009 |
| receptor activity | 1.13726344123824 | bayes_pls_golite062009 |
| receptor signaling protein serine/threonine kinase activity | 1.05231366895645 | bayes_pls_golite062009 |
| transmembrane receptor protein tyrosine kinase activity | 0.96468055729151 | bayes_pls_golite062009 |
| syntaxin binding | 0.909935562401489 | bayes_pls_golite062009 |
| phospholipid binding | 0.847352576231533 | bayes_pls_golite062009 |
| lipid kinase activity | 0.74363752721495 | bayes_pls_golite062009 |
| phosphoinositide 3-kinase activity | 0.62974411024989 | bayes_pls_golite062009 |
| 1-phosphatidylinositol-3-kinase activity | 0.5042126149163 | bayes_pls_golite062009 |
| inositol or phosphatidylinositol kinase activity | 0.328918574945998 | bayes_pls_golite062009 |
| magnesium ion binding | 0.134745748018448 | bayes_pls_golite062009 |
