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View Structure Prediction Details

Protein: shf-PA
Organism: Drosophila melanogaster
Length: 456 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for shf-PA.

Description E-value Query
Range
Subject
Range
gi|74008320 - gi|74008320|ref|XP_865155.1| PREDICTED: similar to odd Oz/ten-m homolog 1 isoform 3 [Canis familiari...
385.0 [0..35] [455..322]

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Predicted Domain #1
Region A:
Residues: [1-100]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTHQGIGCLV KWLYLVLIVH TLLCIGQLEC RQQHHNRNNN NNNRRADSSS SEEGHGNTSD  60
   61 GLDNFADQDA SFVGHGHQPR RGQRKKQQGG GGGGSGGGGG 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [101-162]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NGGGGGSRHN RNEESGISLW INEQQLKMLT ALYFPQGYSE RLYAIHNSRV TNDLRDTTLY  60
   61 NF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.0
Match: 2d3jA
Description: No description for 2d3jA was found.

Predicted Domain #3
Region A:
Residues: [163-456]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LVIPSEVNYV NFTWKSGRRK YFYDFDRLQT MDESILKAPT LSIRKSGRIP QEQKNFSIFL  60
   61 PCTGNSSGTA SFNVGLKIQT RHNKPLSGTP IRLNFKKECA HRGVYDIDAS NPTSLTTLQE 120
  121 CSLKCGKNGY CNEHHICKCN VGYTGQYCET AFCFPQCLNG GNCTAPSVCT CPEGYQGTQC 180
  181 EGGICKDKCL NGGKCIQKDK CQCSKGYYGL RCEYSKCVIP CKNEGRCIGN NLCRCPNGLR 240
  241 GDHCEIGRKQ RSICKCRNGT CVSHKHCKCH PGFYGRHCNG RKRRHVHRND DSKF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.39794
Match: 1n7dA
Description: Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains; Ligand-binding domain of low-density lipoprotein receptor
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
receptor binding 4.60755835611133 bayes_pls_golite062009
growth factor activity 3.72526290796901 bayes_pls_golite062009
binding 2.07793256968292 bayes_pls_golite062009
protein binding 1.71989387545809 bayes_pls_golite062009
glycosaminoglycan binding 1.68731507829717 bayes_pls_golite062009
heparin binding 1.47717701519646 bayes_pls_golite062009
epidermal growth factor receptor binding 1.25957748598741 bayes_pls_golite062009
transcription factor binding 0.697310246671849 bayes_pls_golite062009
ErbB-3 class receptor binding 0.65339109098708 bayes_pls_golite062009
transcription cofactor activity 0.566933146071483 bayes_pls_golite062009
polysaccharide binding 0.50776094968211 bayes_pls_golite062009
ErbB-2 class receptor binding 0.470263535896705 bayes_pls_golite062009
transcription regulator activity 0.396984935987962 bayes_pls_golite062009
pattern binding 0.365394105720783 bayes_pls_golite062009
structural molecule activity 0.076107837006494 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle