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View Structure Prediction Details

Protein: fz4-PA, fz4-PB
Organism: Drosophila melanogaster
Length: 705 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for fz4-PA, fz4-PB.

Description E-value Query
Range
Subject
Range
gi|76661271 - gi|76661271|ref|XP_602576.2| PREDICTED: similar to frizzled 7 [Bos taurus]
379.0 [0..7] [562..456]

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Predicted Domain #1
Region A:
Residues: [1-218]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKPTCILCLL VVILLHPRIS KSSTSGNPSA SSSSSSPPEI PAFRQCETIR IEMCRKIGYN  60
   61 ETSMPNLVGN EMQTDVEYTL QTFAPLIEYD CSSQLKLFLC AAYVPMCTPK APVHAIGPCR 120
  121 SLCESVRIRC HPVLQGFGFP WPPALDCDKF PRENNHETMC MEGPGELHQP QQEQDLYGLP 180
  181 GQGIPGGLGG KLPMDCSGLA KSHLYVRLPR SGRCAPLC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 37.0
Match: 1ijyA
Description: Frizzled 8 (FZ8)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
Wnt receptor activity 5.34849208575619 bayes_pls_golite062009
Wnt-protein binding 4.48351937520811 bayes_pls_golite062009
transmembrane receptor activity 4.38708793497137 bayes_pls_golite062009
receptor activity 4.1046853496316 bayes_pls_golite062009
signal transducer activity 3.17034085692897 bayes_pls_golite062009
molecular transducer activity 3.17034085692897 bayes_pls_golite062009
binding 1.75284371400205 bayes_pls_golite062009
protein binding 1.1012033332744 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [219-577]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EADILFTPAE KHLAEIWVST WAYAALGLAL VATVCLLASD GSRLASAKWS RLLSPLIWCH  60
   61 NMVTLGWAVR FMVGRTGTAC GTDPQAPNES LLTVDGLSNA SCASVFLMRY YFGMAACAWW 120
  121 AVLCLGWHRD IRRHSPDSKG HVVIPSNFGG SPAKRNSAKT AQQDLTQNNF VCFVAWGLPA 180
  181 FQTSAVIVAR FVDADELLGA CFVGNQSDKA LQILVATPVF CYWIFGSMNL ISGYLVHCRT 240
  241 KEILRNSNAL SVQQQLQQLS AHSSSGIGIF LFIYGLACAM LLLAVIYEFA NIDVWLGSGD 300
  301 TNTPLWPFLL RAFMELMLGI CCFAWVLGPS ISTLYKRQVS NGKMVKHTSA GAATGHLDG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.30103
Match: 1f88A
Description: Rhodopsin
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [578-705]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HSSSRGSHAA CNSTVVSYHS VRTSMASVPL PPSPYKLKTS PGTGSISLNQ MSNYSLGRSV  60
   61 HHQQRHSPHH HHHQQQQHHQ FHPHHNHQHH STSSHRLYYP PGSYASQKYS QHGSYYPHLQ 120
  121 QYGNETLL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle