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View Structure Prediction Details

Protein: GIIIspla2-PA
Organism: Drosophila melanogaster
Length: 272 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GIIIspla2-PA.

Description E-value Query
Range
Subject
Range
gi|21483442 - gi|21483442|gb|AAM52696.1| LD41157p [Drosophila melanogaster]
385.0 [0..33] [272..1]
gi|109500917, gi... - ref|XP_223553.1| similar to RIKEN cDNA 9130003P18 [Rattus norvegicus], gi|157822409|ref|NP_001099485...
289.0 [0..58] [267..80]
gi|145207955, gi... - gi|26329257|dbj|BAC28367.1| unnamed protein product [Mus musculus], gi|148708478|gb|EDL40425.1| phos...
266.0 [0..58] [267..76]
gi|114685917 - gi|114685917|ref|XP_525567.2| PREDICTED: phospholipase A2, group III [Pan troglodytes]
254.0 [0..59] [267..81]
gi|123998978, gi... - gi|123998978|gb|ABM87077.1| phospholipase A2, group III [synthetic construct], gi|123986266|gb|ABM83...
PLA2G3 - phospholipase A2, group III
253.0 [0..59] [267..81]
gi|73995445 - gi|73995445|ref|XP_543487.2| PREDICTED: similar to Group III secretory phospholipase A2 precursor (P...
249.0 [0..59] [267..81]
gi|109093964 - gi|109093964|ref|XP_001110828.1| PREDICTED: phospholipase A2, group III [Macaca mulatta]
248.0 [0..59] [267..81]
gi|76639622 - gi|76639622|ref|XP_606026.2| PREDICTED: similar to Group III secretory phospholipase A2 precursor (P...
247.0 [0..59] [267..81]

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Predicted Domain #1
Region A:
Residues: [1-123]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MACADAGQCE HARFVLAAVG EHIKRQCFSD WRAISYGHRT LKKRKAERKQ TELNTMWIAN  60
   61 ERTICALMPL VILATWQLCL LPGTDAKHLA IRLRDPQSEI ESETVPLAHV HSHSHTDESG 120
  121 VRG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.779 a.24.1 Apolipoprotein
View Download 0.663 a.60.10 Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain
View Download 0.617 a.25.2 Thermoplasma ferritin-like 4-helical bundle
View Download 0.607 a.24.1 Apolipoprotein
View Download 0.597 a.7.7 BAG domain
View Download 0.571 a.60.10 Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain
View Download 0.428 f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.382 a.60.10 Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain
View Download 0.381 a.8.3 Families 57/38 glycoside transferase middle domain
View Download 0.375 a.24.9 alpha-catenin/vinculin

Predicted Domain #2
Region A:
Residues: [124-272]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AAAVHRRERR QLSDWLIAPN TRWCGRGNLA NGTYNDLGGA SKADKCCRKH DHCKMWIDGM  60
   61 SNRYDLFNYR PYTLSHCSCD LRFRTCLKMA GDEDANAIGK LFFNVVQTQC FGLKAETVCV 120
  121 QRGGSGKETD PCLKEEVRHK AFLRDNKRF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 50.045757
Match: 1pocA
Description: CRYSTAL STRUCTURE OF BEE-VENOM PHOSPHOLIPASE A2 IN A COMPLEX WITH A TRANSITION-STATE ANALOGUE
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle