| Protein: | Nrg-PB, Nrg-PE, ... |
| Organism: | Drosophila melanogaster |
| Length: | 1302 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Nrg-PB, Nrg-PE, ....
| Description | E-value | Query Range |
Subject Range |
|
|
876.0 | [0..1] | [1252..1] |
|
Region A: Residues: [1-131] |
1 11 21 31 41 51
| | | | | |
1 MWRQSTILAA LLVALLCAGS AESKGNRPPR ITKQPAPGEL LFKVAQQNKE SDNPFIIECE 60
61 ADGQPEPEYS WIKNGKKFDW QAYDNRMLRQ PGRGTLVITI PKDEDRGHYQ CFASNEFGTA 120
121 TSNSVYVRKA E
|
| Detection Method: |  |
| Confidence: | 59.30103 |
| Match: | 1bihA |
| Description: | Hemolin |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| fibroblast growth factor 1 binding | 6.68503380812062 | bayes_pls_golite062009 |
| telethonin binding | 6.64811984458494 | bayes_pls_golite062009 |
| alpha-actinin binding | 5.77350124471385 | bayes_pls_golite062009 |
| actinin binding | 5.69539760434923 | bayes_pls_golite062009 |
| structural constituent of muscle | 4.93896503565413 | bayes_pls_golite062009 |
| olfactory receptor activity | 4.21057154107121 | bayes_pls_golite062009 |
| receptor activity | 4.00123250685257 | bayes_pls_golite062009 |
| antigen binding | 3.82355200401222 | bayes_pls_golite062009 |
| transmembrane receptor activity | 3.81769911097805 | bayes_pls_golite062009 |
| peptide antigen binding | 3.67780971105726 | bayes_pls_golite062009 |
| fibroblast growth factor binding | 3.54458347746523 | bayes_pls_golite062009 |
| fibroblast growth factor receptor activity | 3.20458334492494 | bayes_pls_golite062009 |
| binding | 3.17641566810715 | bayes_pls_golite062009 |
| signal transducer activity | 3.10913345555941 | bayes_pls_golite062009 |
| molecular transducer activity | 3.10913345555941 | bayes_pls_golite062009 |
| IgG binding | 2.37772196119887 | bayes_pls_golite062009 |
| growth factor binding | 2.28613301180608 | bayes_pls_golite062009 |
| protein binding | 2.22855404705168 | bayes_pls_golite062009 |
| IgE receptor activity | 1.73481096568834 | bayes_pls_golite062009 |
| IgE binding | 1.73481096568834 | bayes_pls_golite062009 |
| cytoskeletal protein binding | 1.58610597245454 | bayes_pls_golite062009 |
| transmembrane receptor protein tyrosine kinase activity | 1.52958974617075 | bayes_pls_golite062009 |
| actin binding | 1.42681407553255 | bayes_pls_golite062009 |
| cell adhesion molecule binding | 1.36789541796983 | bayes_pls_golite062009 |
| nucleic acid binding | 1.32330470851159 | bayes_pls_golite062009 |
| transmembrane receptor protein kinase activity | 1.30657787244536 | bayes_pls_golite062009 |
| sugar binding | 1.26337823485694 | bayes_pls_golite062009 |
| DNA binding | 1.19412627500732 | bayes_pls_golite062009 |
| transcription regulator activity | 1.16252234499274 | bayes_pls_golite062009 |
| G-protein coupled receptor activity | 1.02428106476324 | bayes_pls_golite062009 |
| myosin light chain kinase activity | 0.87238163212 | bayes_pls_golite062009 |
| protein complex binding | 0.83543827718565 | bayes_pls_golite062009 |
| immunoglobulin receptor activity | 0.803684061893919 | bayes_pls_golite062009 |
| actin filament binding | 0.760856470721016 | bayes_pls_golite062009 |
| collagen binding | 0.729893120256353 | bayes_pls_golite062009 |
| peptide binding | 0.729048089532569 | bayes_pls_golite062009 |
| immunoglobulin binding | 0.64138121404685 | bayes_pls_golite062009 |
| receptor binding | 0.632627479346393 | bayes_pls_golite062009 |
| cytokine binding | 0.631436442105379 | bayes_pls_golite062009 |
| titin binding | 0.599892148302011 | bayes_pls_golite062009 |
| integrin binding | 0.599569390248921 | bayes_pls_golite062009 |
| protein kinase activity | 0.589015157128768 | bayes_pls_golite062009 |
| transcription factor activity | 0.54549168007511 | bayes_pls_golite062009 |
| monosaccharide binding | 0.533047672054027 | bayes_pls_golite062009 |
| IgG receptor activity | 0.50231877534761 | bayes_pls_golite062009 |
| myosin heavy chain binding | 0.49788128784685 | bayes_pls_golite062009 |
| cell surface binding | 0.477483205369537 | bayes_pls_golite062009 |
| cytokine receptor activity | 0.34165331857492 | bayes_pls_golite062009 |
| phosphotransferase activity, alcohol group as acceptor | 0.300034766861208 | bayes_pls_golite062009 |
| kinase activity | 0.232190923918901 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 0.182775558017364 | bayes_pls_golite062009 |
| structural constituent of cytoskeleton | 0.0579247757286607 | bayes_pls_golite062009 |
| protein serine/threonine kinase activity | 0.026512949804781 | bayes_pls_golite062009 |
| structural molecule activity | 0.00139730528977644 | bayes_pls_golite062009 |
|
Region A: Residues: [132-614] |
1 11 21 31 41 51
| | | | | |
1 LNAFKDEAAK TLEAVEGEPF MLKCAAPDGF PSPTVNWMIQ ESIDGSIKSI NNSRMTLDPE 60
61 GNLWFSNVTR EDASSDFYYA CSATSVFRSE YKIGNKVLLD VKQMGVSASQ NKHPPVRQYV 120
121 SRRQSLALRG KRMELFCIYG GTPLPQTVWS KDGQRIQWSD RITQGHYGKS LVIRQTNFDD 180
181 AGTYTCDVSN GVGNAQSFSI ILNVNSVPYF TKEPEIATAA EDEEVVFECR AAGVPEPKIS 240
241 WIHNGKPIEQ STPNPRRTVT DNTIRIINLV KGDTGNYGCN ATNSLGYVYK DVYLNVQAEP 300
301 PTISEAPAAV STVDGRNVTI KCRVNGSPKP LVKWLRASNW LTGGRYNVQA NGDLEIQDVT 360
361 FSDAGKYTCY AQNKFGEIQA DGSLVVKEHT RITQEPQNYE VAAGQSATFR CNEAHDDTLE 420
421 IEIDWWKDGQ SIDFEAQPRF VKTNDNSLTI AKTMELDSGE YTCVARTRLD EATARANLIV 480
481 QDV
|
| Detection Method: | |
| Confidence: | 18.221849 |
| Match: | 2ocwA |
| Description: | No description for 2ocwA was found. |
|
Region A: Residues: [615-711] |
1 11 21 31 41 51
| | | | | |
1 PNAPKLTGIT CQADKAEIHW EQQGDNRSPI LHYTIQFNTS FTPASWDAAY EKVPNTDSSF 60
61 VVQMSPWANY TFRVIAFNKI GASPPSAHSD SCTTQPD
|
| Detection Method: | |
| Confidence: | 31.0 |
| Match: | 2nziA |
| Description: | No description for 2nziA was found. |
|
Region A: Residues: [712-792] |
1 11 21 31 41 51
| | | | | |
1 VPFKNPDNVV GQGTEPNNLV ISWTPMPEIE HNAPNFHYYV SWKRDIPAAA WENNNIFDWR 60
61 QNNIVIADQP TFVKYLIKVV A
|
| Detection Method: | |
| Confidence: | 30.522879 |
| Match: | 1cfbA |
| Description: | CRYSTAL STRUCTURE OF TANDEM TYPE III FIBRONECTIN DOMAINS FROM DROSOPHILA NEUROGLIAN AT 2.0 ANGSTROMS |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [793-1119] |
1 11 21 31 41 51
| | | | | |
1 INDRGESNVA AEEVVGYSGE DRPLDAPTNF TMRQITSSTS GYMAWTPVSE ESVRGHFKGY 60
61 KIQTWTENEG EEGLREIHVK GDTHNALVTQ FKPDSKNYAR ILAYNGRFNG PPSAVIDFDT 120
121 PEGVPSPVQG LDAYPLGSSA FMLHWKKPLY PNGKLTGYKI YYEEVKESYV GERREYDPHI 180
181 TDPRVTRMKM AGLKPNSKYR ISITATTKMG EGSEHYIEKT TLKDAVNVAP ATPSFSWEQL 240
241 PSDNGLAKFR INWLPSTEGH PGTHFFTMHR IKGETQWIRE NEEKNSDYQE VGGLDPETAY 300
301 EFRVVSVDGH FNTESATQEI DTNTVEG
|
| Detection Method: | |
| Confidence: | 12.221849 |
| Match: | 1gh7A |
| Description: | Common beta-chain in the GM-CSF, IL-3 and IL-5 receptors |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| telethonin binding | 5.81747667416248 | bayes_pls_golite062009 |
| structural constituent of muscle | 5.71979489668015 | bayes_pls_golite062009 |
| transmembrane receptor activity | 4.81256300373074 | bayes_pls_golite062009 |
| ankyrin binding | 4.69755754047169 | bayes_pls_golite062009 |
| receptor activity | 4.66147271961356 | bayes_pls_golite062009 |
| alpha-actinin binding | 4.57951951779666 | bayes_pls_golite062009 |
| actinin binding | 4.57900103206288 | bayes_pls_golite062009 |
| cytokine binding | 4.43581512268554 | bayes_pls_golite062009 |
| cytokine receptor activity | 4.08668869714207 | bayes_pls_golite062009 |
| growth factor binding | 4.06808996928726 | bayes_pls_golite062009 |
| molecular transducer activity | 3.69234048247377 | bayes_pls_golite062009 |
| signal transducer activity | 3.69234048247377 | bayes_pls_golite062009 |
| protein binding | 3.24522318184038 | bayes_pls_golite062009 |
| binding | 3.12471204223368 | bayes_pls_golite062009 |
| interleukin-2 binding | 2.38131482184802 | bayes_pls_golite062009 |
| cell adhesion molecule binding | 2.32179186005318 | bayes_pls_golite062009 |
| prolactin receptor activity | 2.15346920063421 | bayes_pls_golite062009 |
| ciliary neurotrophic factor receptor activity | 2.15011619378442 | bayes_pls_golite062009 |
| peptide hormone binding | 2.12033076929638 | bayes_pls_golite062009 |
| axon guidance receptor activity | 2.01367445237355 | bayes_pls_golite062009 |
| interleukin-6 receptor activity | 1.9781930293417 | bayes_pls_golite062009 |
| interleukin-6 binding | 1.9781930293417 | bayes_pls_golite062009 |
| cytoskeletal protein binding | 1.85720106085239 | bayes_pls_golite062009 |
| polysaccharide binding | 1.69642470905172 | bayes_pls_golite062009 |
| glycosaminoglycan binding | 1.6158868405814 | bayes_pls_golite062009 |
| interleukin-11 receptor activity | 1.57103867592521 | bayes_pls_golite062009 |
| interleukin-11 binding | 1.57103867592521 | bayes_pls_golite062009 |
| heparin binding | 1.40418056272895 | bayes_pls_golite062009 |
| nucleic acid binding | 1.32813363771214 | bayes_pls_golite062009 |
| receptor binding | 1.31676259534833 | bayes_pls_golite062009 |
| transcription regulator activity | 1.31663344632755 | bayes_pls_golite062009 |
| leukemia inhibitory factor receptor activity | 1.27120658254426 | bayes_pls_golite062009 |
| oncostatin-M receptor activity | 1.27120658254426 | bayes_pls_golite062009 |
| actin binding | 1.21472460452555 | bayes_pls_golite062009 |
| DNA binding | 1.2006039770643 | bayes_pls_golite062009 |
| myosin light chain kinase activity | 1.18611050638993 | bayes_pls_golite062009 |
| cell surface binding | 1.05599555585797 | bayes_pls_golite062009 |
| ciliary neurotrophic factor binding | 1.02710126648804 | bayes_pls_golite062009 |
| sialic acid binding | 0.992369242781511 | bayes_pls_golite062009 |
| interleukin-7 binding | 0.992216255634359 | bayes_pls_golite062009 |
| peptide binding | 0.92031154055894 | bayes_pls_golite062009 |
| protein dimerization activity | 0.86564366658585 | bayes_pls_golite062009 |
| interleukin-2 receptor activity | 0.817385502041609 | bayes_pls_golite062009 |
| collagen binding | 0.688581536921572 | bayes_pls_golite062009 |
| kinase binding | 0.65927255037265 | bayes_pls_golite062009 |
| protein kinase activity | 0.651225820536084 | bayes_pls_golite062009 |
| enzyme binding | 0.60195860585095 | bayes_pls_golite062009 |
| identical protein binding | 0.564711394496051 | bayes_pls_golite062009 |
| transcription factor activity | 0.557290274937694 | bayes_pls_golite062009 |
| transmembrane receptor protein tyrosine kinase activity | 0.554350228628563 | bayes_pls_golite062009 |
| sugar binding | 0.525326551675751 | bayes_pls_golite062009 |
| hormone binding | 0.49524185948356 | bayes_pls_golite062009 |
| transmembrane receptor protein kinase activity | 0.46168925186147 | bayes_pls_golite062009 |
| phosphotransferase activity, alcohol group as acceptor | 0.436168003057537 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 0.425601964126369 | bayes_pls_golite062009 |
| kinase activity | 0.412589450700334 | bayes_pls_golite062009 |
| structural constituent of cytoskeleton | 0.40600177052491 | bayes_pls_golite062009 |
| protein kinase binding | 0.405060010394646 | bayes_pls_golite062009 |
| structural molecule activity | 0.37617823184103 | bayes_pls_golite062009 |
| monosaccharide binding | 0.356315624949755 | bayes_pls_golite062009 |
| ciliary neurotrophic factor receptor binding | 0.338520586013721 | bayes_pls_golite062009 |
| pattern binding | 0.16768253393396 | bayes_pls_golite062009 |
| protein serine/threonine kinase activity | 0.16524109571346 | bayes_pls_golite062009 |
| protein heterodimerization activity | 0.1430595594485 | bayes_pls_golite062009 |
| transcription activator activity | 0.135753557343301 | bayes_pls_golite062009 |
| actin filament binding | 0.135484838710405 | bayes_pls_golite062009 |
| protein homodimerization activity | 0.116391819218123 | bayes_pls_golite062009 |
| integrin binding | 0.0873424694168858 | bayes_pls_golite062009 |
| transcription factor binding | 0.075900818564989 | bayes_pls_golite062009 |
| cytokine receptor binding | 0.0682540643558203 | bayes_pls_golite062009 |
| growth factor activity | 0.0477008672713168 | bayes_pls_golite062009 |
|
Region A: Residues: [1120-1302] |
1 11 21 31 41 51
| | | | | |
1 PIMVANETVA NAGWFIGMML ALAFIIILFI IICIIRRNRG GKYDVHDREL ANGRRDYPEE 60
61 GGFHEYSQPL DNKSAGRQSV SSANKPGVES DTDSMAEYGD GDTGQFTEDG SFIGQYVPGK 120
121 LQPPVSPQPL NNSAAAHQAA PTAGGSGAAG SAAAAGASGG ASSAGGAAAS NGGAAAGAVA 180
181 TYV
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
