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View Structure Prediction Details

Protein: FBpp0309304, FBp...
Organism: Drosophila melanogaster
Length: 1038 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FBpp0309304, FBp....

Description E-value Query
Range
Subject
Range
gi|77403901 - gi|77403901|gb|ABA81829.1| LP20363p [Drosophila melanogaster]
1016.0 [0..1] [1038..1]

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Predicted Domain #1
Region A:
Residues: [1-92]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MANKLRKSNA IEWATATGTV PLLERSCCHS EDAALEPQAS KTSHREQAPI LRHLSQLSHL  60
   61 LIIAGLLIVC LAGVTEGRRH APLMFEESDT GR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [93-177]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RSNRPAVTEC QFGKVLRELG STWYADLGPP FGVMYCIKCE CVAIPKKRRI VARVQCRNIK  60
   61 NECPPAKCDD PISLPGKCCK TCPGD

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.22
Match: 1u5mA
Description: Structure of a Chordin-like Cysteine-rich Repeat (VWC module) from Collagen IIA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
extracellular matrix structural constituent 4.15933718640855 bayes_pls_golite062009
platelet-derived growth factor binding 3.82504499599732 bayes_pls_golite062009
growth factor binding 3.07979418958893 bayes_pls_golite062009
protein binding 2.13859012595807 bayes_pls_golite062009
binding 1.72922707266313 bayes_pls_golite062009
SMAD binding 1.58863880004415 bayes_pls_golite062009
receptor binding 1.47786086313432 bayes_pls_golite062009
integrin binding 1.24144638872639 bayes_pls_golite062009
extracellular matrix structural constituent conferring tensile strength 0.493781546820044 bayes_pls_golite062009
protein complex binding 0.438148656492799 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [178-279]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RNDTDVALDV PVPNEEEERN MKHYAALLTG RTSYFLKGEE MKSMYTTYNP QNVVATARFL  60
   61 FHKKNLYYSF YTSSRIGRPR AIQFVDDAGV ILEEHQLETT LA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [280-482]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GTLSVYQNAT GKICGVWRRV PRDYKRILRD DRLHVVLLWG NKQQAELALA GKVAKYTALQ  60
   61 TELFSSLLEA PLPDGKTDPQ LAGAGGTAIV STSSGAASSM HLTLVFNGVF GAEEYADAAL 120
  121 SVKIELAERK EVIFDEIPRV RKPSAEINVL ELSSPISIQN LRLMSRGKLL LTVESKKYPH 180
  181 LRIQGHIVTR ASCEIFQTLL APH

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [483-637]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SAESSTKSSG LAWVYLNTDG SLAYNIETEH VNTRDRPNIS LIEEQGKRKA KLEDLTPSFN  60
   61 FNQAIGSVEK LGPKVLESLY AGELGVNVAT EHETSLIRGR LVPRPVADAR DSAEPILLKR 120
  121 QEHTDAQNPH AVGMAWMSID NECNLHYEVT LNGVP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [638-1038]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AQDLQLYLEE KPIEAIGAPV TRKLLEEFNG SYLEGFFLSM PSAELIKLEM SVCYLEVHSK  60
   61 HSKQLLLRGK LKSTKVPGHC FPVYTDNNVP VPGDHNDNHL VNGETKCFHS GRFYNESEQW 120
  121 RSAQDSCQMC ACLRGQSSCE VIKCPALKCK STEQLLQRDG ECCPSCVPKK EAADYSAQSS 180
  181 PATNATDLLQ QRRGCRLGEQ FHPAGASWHP FLPPNGFDTC TTCSCDPLTL EIRCPRLVCP 240
  241 PLQCSEKLAY RPDKKACCKI CPEGKQSSSN GHKTTPNNPN VLQDQAMQRS PSHSAEEVLA 300
  301 NGGCKVVNKV YENGQEWHPI LMSHGEQKCI KCRCKDSKVN CDRKRCSRST CQQQTRVTSK 360
  361 RRLFEKPDAA APAIDECCST QCRRSRRHHK RQPHHQQRSS S

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.221849
Match: 1n7dA
Description: Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains; Ligand-binding domain of low-density lipoprotein receptor
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
receptor binding 4.33045214660893 bayes_pls_golite062009
growth factor activity 3.53240291240997 bayes_pls_golite062009
epidermal growth factor receptor binding 3.23778562911102 bayes_pls_golite062009
protein binding 3.02592228806142 bayes_pls_golite062009
glycosaminoglycan binding 2.86713236325679 bayes_pls_golite062009
ErbB-2 class receptor binding 2.56367101923009 bayes_pls_golite062009
heparin binding 2.49012176521764 bayes_pls_golite062009
binding 2.33940742543305 bayes_pls_golite062009
ErbB-3 class receptor binding 2.197145317433 bayes_pls_golite062009
pattern binding 1.7855850180475 bayes_pls_golite062009
molecular transducer activity 1.66401431847753 bayes_pls_golite062009
signal transducer activity 1.66401431847753 bayes_pls_golite062009
polysaccharide binding 1.52943230565474 bayes_pls_golite062009
extracellular matrix structural constituent 0.87690248187077 bayes_pls_golite062009
transcription factor binding 0.795087651578297 bayes_pls_golite062009
cell adhesion molecule binding 0.44857826904729 bayes_pls_golite062009
carbohydrate binding 0.37481112933019 bayes_pls_golite062009
glycoprotein binding 0.128291636237359 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle