YRC Public Data Repository - Protein Structure Prediction

Protein:	cwf24
Organism:	Schizosaccharomyces pombe
Length:	533 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for cwf24.

Description	E-value	Query Range	Subject Range
gi\|61370453, gi\|... - gi\|61370453\|gb\|AAX43498.1\| zinc finger protein 183 [synthetic construct], gi\|61370447\|gb\|AAX43497.1\|...	216.0	[0..10]	[311..4]
gi\|109132082 - gi\|109132082\|ref\|XP_001083433.1\| PREDICTED: ring finger protein 113A [Macaca mulatta]	216.0	[0..10]	[311..4]
gi\|61360729, gi\|... - gi\|61360729\|gb\|AAX41914.1\| zinc finger protein 183 [synthetic construct], gi\|208968725\|dbj\|BAG74201.... RNF113A - ring finger protein 113A	216.0	[0..10]	[311..4]
gi\|55664148 - gi\|55664148\|ref\|XP_529135.1\| PREDICTED: ring finger protein 113A [Pan troglodytes]	216.0	[0..10]	[311..4]
gi\|19354278, gi\|... - gi\|23943840\|ref\|NP_705723.1\| ring finger protein 113A1 [Mus musculus], gi\|19354278\|gb\|AAH24906.1\| Ri...	215.0	[0..10]	[305..4]
gi\|40891590 - gi\|40891590\|gb\|AAR97521.1\| zinc finger protein 183 [Rattus norvegicus]	214.0	[0..10]	[305..4]

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Predicted Domain #1

Region A:
Residues: [1-138]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEQKNLNINQ ASGSKINTEL AVPIFQSRRR HRPRQGLKRK KGFKRDDDSG GSSESSNEDM  60
   61 RDNIPIVSGR KKTVRLNRLQ RESEQFENSA LKDINVEYQS NLSATGESVN TTTVSAINED 120
  121 TREVILGRPS PKLANQST

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [139-229]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPTELFQSQN DYSRFLPKRK DFEKKSQVGP VLSSNASTVR MNTIIDYQPD VCKDYKLTGY  60
   61 CGYGDTCKFL HMREDYKAGW QLDREWDSVQ E

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.49
Match:	2cqeA
Description:	Solution Structure of the Zinc-finger domain in KIAA1064 protein
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [230-363]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KYKKGAKLEE GMVKNEKKED IPFVCLICKK DYRSPIATTC GHHFCEQCAI TRYRKTPTCI  60
   61 QCGADTKGLF SVDKNFDRLL KNRKSKNDEA VKQKVGGFES NNSATTEVSE RKDREASFQG 120
  121 FADTLAKPNT SAQQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	13.09691
Match:	1rmdA
Description:	RAG1 DIMERIZATION DOMAIN
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ubiquitin-protein ligase activity	5.78506998502716	bayes_pls_golite062009
small conjugating protein ligase activity	5.55686022186257	bayes_pls_golite062009
	4.77196423114965	bayes_pls_golite062009
acid-amino acid ligase activity	4.59153177011595	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	3.07217714843839	bayes_pls_golite062009
RNA binding	3.04658201081989	bayes_pls_golite062009
snRNA binding	2.60432246247067	bayes_pls_golite062009
U1 snRNA binding	2.4012085357866	bayes_pls_golite062009
ligase activity	2.30828657077565	bayes_pls_golite062009
binding	2.19426901055464	bayes_pls_golite062009
protein binding	1.73461977726143	bayes_pls_golite062009
transcription regulator activity	1.62076236255768	bayes_pls_golite062009
mRNA binding	1.30742677372942	bayes_pls_golite062009
nucleic acid binding	1.22180889694654	bayes_pls_golite062009
small conjugating protein-specific protease activity	1.2126425713931	bayes_pls_golite062009
ubiquitin-specific protease activity	1.03469202541773	bayes_pls_golite062009
DNA binding	1.00346149950987	bayes_pls_golite062009
chromatin binding	0.89589330553881	bayes_pls_golite062009
cysteine-type peptidase activity	0.50197530717959	bayes_pls_golite062009
specific RNA polymerase II transcription factor activity	0.47352407708364	bayes_pls_golite062009
transcription factor binding	0.39685947299825	bayes_pls_golite062009
transcription factor activity	0.382098789505496	bayes_pls_golite062009
ubiquitin thiolesterase activity	0.265769062717221	bayes_pls_golite062009
structure-specific DNA binding	0.240825841910931	bayes_pls_golite062009
catalytic activity	0.14112008370434	bayes_pls_golite062009
double-stranded DNA binding	0.0129353639725593	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [364-425]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KMPSLGDNSN TIISKYFIRE ITESNIVHFK RLVRVVLEAS YSDKFYRLVL KNPDYARIAT  60
   61 FE

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5

Region A:
Residues: [426-533]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DKFVGAISSL VAEDNSLYVT VLCVLAPYRC LGIGSLLIDH VKKTAINNNI DRISLHVQTT  60
   61 NESVIKWYTA HGFKIVKQIN DFYRRLENKS AFYMVCPLSA HNNIISNH

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	15.221849
Match:	2ob0A
Description:	No description for 2ob0A was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: