YRC Public Data Repository - Protein Structure Prediction

Protein:	brf1
Organism:	Schizosaccharomyces pombe
Length:	500 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for brf1.

Description	E-value	Query Range	Subject Range
BRF1 - BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)	383.0	[0..6]	[494..1]
TF3B_MOUSE - Transcription factor IIIB 90 kDa subunit OS=Mus musculus GN=Brf1 PE=1 SV=1	383.0	[0..6]	[494..1]
gi\|109480055, gi... - gi\|62651305\|ref\|XP_216801.3\| PREDICTED: similar to transcription initiation factor IIIB [Rattus norv...	382.0	[0..6]	[494..1]
gi\|28422474, gi\|... - gi\|41054023\|ref\|NP_956192.1\| BRF1 homolog, subunit of RNA polymerase III transcription initiation fa...	361.0	[0..10]	[494..3]
gi\|52354750, gi\|... - gi\|52354750\|gb\|AAH82860.1\| LOC494758 protein [Xenopus laevis], gi\|162287069\|ref\|NP_001088063.1\| hypo...	350.0	[0..6]	[494..1]
gi\|114655135 - gi\|114655135\|ref\|XP_510208.2\| PREDICTED: transcription initiation factor IIIB [Pan troglodytes]	341.0	[0..71]	[494..209]

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Predicted Domain #1

Region A:
Residues: [1-66]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLCFQLFAMG CPNCGSTTFE SDTASGNTYC TQCGVVVEQD AIVSEVTFGE ASTGAAVVQG  60
   61 SLVSND

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [67-282]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QTHARTFGGP YRNQGSVESR ELTIANGRRR ISALAIALKL NERHIEAAVR YFTLAINNNF  60
   61 IKGRRSQYVV ASCLYIVCRI SKTSHMLIDF SDILQINVFK LGSTFLKLCR VLRPNLPLLD 120
  121 PSLYISRFAS LLEFGPETHR VANDAIRLVA RMNRDWMQIG RRPAGICGAC LLIAARMNNF 180
  181 RRSVREVVHV VKVADITIQK RLDEFKLTES GDLSIA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	51.0
Match:	2b9rA
Description:	No description for 2b9rA was found.

Predicted Domain #3

Region A:
Residues: [283-368]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DFRNIWLEGQ SDPPSFTKNQ KFQQYGAQKV SNIDHTQEYM SPIKRTPDFD GNEVKSEELS  60
   61 QTVKVESQET PVHLKADERE IRKEVT

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4

Region A:
Residues: [369-500]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ETLKGDELRK ISLQVNVKFS EEEVTLEDVD DDEIEDILLD KDEILTKTQV WMELNKDYLA  60
   61 EEEAKNLKLQ EDLKKGIVRQ PRKRRRYRPR DSTSDGIADT AAESAKEMMQ QRAFSKKINY 120
  121 EALDMLFDEE QS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	11.045757
Match:	1ngmB
Description:	TBP-binding domain of the transcription factor IIIb Brf1 subunit
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits