YRC Public Data Repository - Protein Structure Prediction

Protein:	SPBC23E6.10c
Organism:	Schizosaccharomyces pombe
Length:	359 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPBC23E6.10c.

Description	E-value	Query Range	Subject Range
MTNA_THEMA - Methylthioribose-1-phosphate isomerase OS=Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 /... MTNA_THEMA - Methylthioribose-1-phosphate isomerase OS=Thermotoga maritima GN=mtnA PE=1 SV=1	400.0	[0..4]	[350..6]
MTNA_GEOMG - Methylthioribose-1-phosphate isomerase OS=Geobacter metallireducens (strain GS-15 / ATCC 53774 / DSM...	397.0	[0..1]	[349..1]
MTNA_GEOSL - Methylthioribose-1-phosphate isomerase OS=Geobacter sulfurreducens GN=mtnA PE=3 SV=1 MTNA_GEOSL - Methylthioribose-1-phosphate isomerase OS=Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / ...	396.0	[0..1]	[349..1]
MTNA_NOSP7 - Methylthioribose-1-phosphate isomerase OS=Nostoc punctiforme (strain ATCC 29133 / PCC 73102) GN=mtnA...	393.0	[0..3]	[358..8]
MTNA_GEOUR - Methylthioribose-1-phosphate isomerase OS=Geobacter uraniireducens (strain Rf4) GN=mtnA PE=3 SV=1	391.0	[0..1]	[348..1]
MTNA_GEODF - Methylthioribose-1-phosphate isomerase OS=Geobacter daltonii (strain DSM 22248 / JCM 15807 / FRC-32)...	389.0	[0..1]	[348..1]
MTNA_ANAVT - Methylthioribose-1-phosphate isomerase OS=Anabaena variabilis (strain ATCC 29413 / PCC 7937) GN=mtnA...	388.0	[0..3]	[355..2]
MTNA_SYNEL - Methylthioribose-1-phosphate isomerase OS=Synechococcus elongatus GN=mtnA PE=3 SV=1 MTNA_THEEB - Methylthioribose-1-phosphate isomerase OS=Thermosynechococcus elongatus (strain BP-1) GN=mtnA PE=3 S...	386.0	[0..2]	[355..9]
gi\|21593194 - gi\|21593194\|gb\|AAM65143.1\| putative translation initiation factor eIF-2B alpha subunit [Arabidopsis ...	386.0	[0..2]	[359..8]
MTNA_NOSS1 - Methylthioribose-1-phosphate isomerase OS=Nostoc sp. (strain PCC 7120 / UTEX 2576) GN=mtnA PE=3 SV=1 gi\|25315920 - pir\|\|AG2251 translation initiation factor IF-2B alpha chain [imported] - Nostoc sp. (strain PCC 7120...	386.0	[0..3]	[350..2]

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Predicted Domain #1

Region A:
Residues: [1-359]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLQAIIYNE DKLLVLDQLL LPYERKYISV SNVEDAFAVI KKMQVRGAPA IAIVAALSVA  60
   61 VGLKHLSEDA DAKEYVINSF EHLKQSRPTA VNLFETAKFM QGIALQEGKN CRNKIIQEAE 120
  121 RMLVKDLEDN HNIGTAGRKF LLQHYKDKDK LTVLTHCNTG SLATSGYGTA LGIIRSLHES 180
  181 GNLEHAYCTE TRPYNQGSRL TAFELVHDKI PATLVTDSTV ASIMHKIDAI VVGADRVTRN 240
  241 GDTANKIGTY NLAILAKHFG KPFIVAAPFS SIDTSLASGS QITIEQRPPI EMTTITGPII 300
  301 TDSNSRNLED PKRVRISIAA PGIDVYSPAF DVTPANLITA IATEKGFYTQ QTNNKYDFS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	112.0
Match:	1t9kA
Description:	X-ray crystal structure of aIF-2B alpha subunit-related translation initiation factor [Thermotoga maritima]
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
translation initiation factor activity	10.1099993541596	bayes_pls_golite062009
translation regulator activity	5.74669335554405	bayes_pls_golite062009
nucleic acid binding	2.17718456512191	bayes_pls_golite062009
transcription regulator activity	1.9283980201455	bayes_pls_golite062009
DNA binding	1.55389679363348	bayes_pls_golite062009
binding	1.53908996868286	bayes_pls_golite062009
transferase activity, transferring sulfur-containing groups	1.40526340076289	bayes_pls_golite062009
catalytic activity	1.31732715713197	bayes_pls_golite062009
translation factor activity, nucleic acid binding	1.09424756417577	bayes_pls_golite062009
transcription factor activity	0.995059566132783	bayes_pls_golite062009
deaminase activity	0.518630450774121	bayes_pls_golite062009
S-methyl-5-thioribose-1-phosphate isomerase activity	0.511292518421556	bayes_pls_golite062009
protein binding	0.0293610121675921	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: