YRC Public Data Repository - Protein Structure Prediction

Protein:	rga9
Organism:	Schizosaccharomyces pombe
Length:	684 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for rga9.

Description	E-value	Query Range	Subject Range
gi\|67539014, gi\|... - gi\|67539014\|ref\|XP_663281.1\| hypothetical protein AN5677.2 [Aspergillus nidulans FGSC A4], ref\|XP_40...	326.0	[0..4]	[682..3]
gi\|42554607, gi\|... - gi\|46126111\|ref\|XP_387609.1\| hypothetical protein FG07433.1 [Gibberella zeae PH-1], gi\|42554607\|gb\|E...	325.0	[0..4]	[682..3]
gi\|39961454, gi\|... - gi\|39961454\|ref\|XP_364686.1\| hypothetical protein MG09531.4 [Magnaporthe grisea 70-15], gb\|EAA53781....	320.0	[0..5]	[682..4]
gi\|115395204, gi... - gi\|115395204\|ref\|XP_001213489.1\| conserved hypothetical protein [Aspergillus terreus NIH2624], gi\|11...	316.0	[0..4]	[682..3]
gi\|38566867, gi\|... - gi\|38566867\|emb\|CAE76173.1\| related to GTPase activating protein [Neurospora crassa], gi\|32418836\|re... gi\|85091140 - gi\|85091140\|ref\|XP_958756.1\| hypothetical protein NCU09537 [Neurospora crassa OR74A]	313.0	[0..4]	[682..3]
gi\|169765516 - gi\|169765516\|ref\|XP_001817229.1\| hypothetical protein [Aspergillus oryzae RIB40] gi\|83765084 - gi\|83765084\|dbj\|BAE55227.1\| unnamed protein product [Aspergillus oryzae]	306.0	[0..1]	[682..1]
gi\|111067753 - gi\|111067753\|gb\|EAT88873.1\| hypothetical protein SNOG_03668 [Phaeosphaeria nodorum SN15]	304.0	[0..1]	[669..1]
RGA8_SCHPO - Rho-GTPase-activating protein 8 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=rga8 PE=1 ... rga8 - GTPase activating protein Rga8	303.0	[0..1]	[682..1]
gi\|90299147, gi\|... - gi\|90299147\|gb\|EAS28778.1\| hypothetical protein CIMG_07524 [Coccidioides immitis RS], gi\|119177063\|r...	302.0	[0..4]	[682..3]
gi\|116206290, gi... - gi\|88183035\|gb\|EAQ90503.1\| hypothetical protein CHGG_02438 [Chaetomium globosum CBS 148.51], gi\|1162...	301.0	[0..4]	[682..3]

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Predicted Domain #1

Region A:
Residues: [1-256]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MWDGFSNSFW SRDYITGINR AQRLINEGVE QNEKLLQLLH IRAKSASSCS DLLFKSFSKF  60
   61 NKHHPLNEES NDLPSDAAIH QLYESYLMEA SLHKKLGEQL NILVINPFAN WSKKYSRRVD 120
  121 EIVSAAIVKI NNYNSRFSHV NSKKSNLTDR KPIPTSRKSN KSDSLASALS QLDINPSNVN 180
  181 KFDGLINIVD HPYTAEEFAN VLLKLMKAST VKRKSYSHLG DYELVTNCSL LFEAIKTTFG 240
  241 LEKDSYVVKA GNQLIQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	27.69897
Match:	2eflA
Description:	No description for 2eflA was found.

Predicted functions:

Term	Confidence	Notes
cytoskeletal protein binding	3.124619761789	bayes_pls_golite062009
binding	2.22529267810903	bayes_pls_golite062009
protein binding	1.87308005875135	bayes_pls_golite062009
identical protein binding	0.909409198394921	bayes_pls_golite062009
enzyme binding	0.58709209959999	bayes_pls_golite062009
GTPase binding	0.50066793947946	bayes_pls_golite062009
GTPase regulator activity	0.459881864914566	bayes_pls_golite062009
nucleoside-triphosphatase regulator activity	0.456472132383968	bayes_pls_golite062009
enzyme regulator activity	0.180886944097381	bayes_pls_golite062009
small GTPase binding	0.0531578648468707	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [257-684]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HGLIRLLGIR RVFENDPEID AQFTTKSQQL LKSYHLSILE VDPYFQVNDP ITATNDDPVL  60
   61 QKYNLAYDNL EQCRHELELY LVLSIILLSF ANPFQFMVFK DLEQAELDRL NAVKSVLVEC 120
  121 SNYSGNFIPS LNSIFIDNLN SFKNLDSLRD MSTQINKHYT GYFIPVSNNE LSTKDEYLFL 180
  181 QKSSLTEDNL IVSLVPKILA YLLDAYSYER DEEVLSCVWT TEVPLKDAFD LKSVLRKTDN 240
  241 VESVLNACVE KYTLSSITCS LRLCLLEFPD SLIRSSFYDY FKAIYTTYTD FEDLDHRLYS 300
  301 IKKCLLHLHS TPLHILEEII RHLSAYAISI RMKDGQIRHL AKIISPCVLR PPDDLNIIPV 360
  361 EDTHPTLLVI DLINEFENLF ADLERPSTPP VEIERALTPI TTSPQKLKLP RSSSPCKNPS 420
  421 PTRRFRPF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	51.0
Match:	1xa6A
Description:	Crystal Structure of the Human Beta2-Chimaerin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
Rho GTPase activator activity	4.58620967349979	bayes_pls_golite062009
Rac GTPase activator activity	4.48279904625182	bayes_pls_golite062009
cytoskeletal protein binding	3.68681762274025	bayes_pls_golite062009
actin binding	3.68337819140185	bayes_pls_golite062009
GTPase regulator activity	2.70614727793157	bayes_pls_golite062009
nucleoside-triphosphatase regulator activity	2.68579854252375	bayes_pls_golite062009
actin filament binding	2.37781909937968	bayes_pls_golite062009
microfilament motor activity	2.15518436158221	bayes_pls_golite062009
binding	2.15139804299723	bayes_pls_golite062009
guanyl-nucleotide exchange factor activity	2.06038764955701	bayes_pls_golite062009
enzyme regulator activity	1.9750017471254	bayes_pls_golite062009
small GTPase regulator activity	1.95738547986197	bayes_pls_golite062009
diacylglycerol binding	1.32295764006263	bayes_pls_golite062009
protein binding	1.29100556128076	bayes_pls_golite062009
Ras GTPase activator activity	1.09070479183477	bayes_pls_golite062009
Rho guanyl-nucleotide exchange factor activity	0.967362611034944	bayes_pls_golite062009
Ras guanyl-nucleotide exchange factor activity	0.958295643211986	bayes_pls_golite062009
myosin heavy chain kinase activity	0.847021935833721	bayes_pls_golite062009
GTPase activator activity	0.717730683557543	bayes_pls_golite062009
enzyme activator activity	0.298334474872045	bayes_pls_golite062009
transcription regulator activity	0.0455432286632499	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: