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View Structure Prediction Details

Protein: hlh-1
Organism: Caenorhabditis elegans
Length: 324 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for hlh-1.

Description E-value Query
Range
Subject
Range
gi|102462 - gi|102462|pir||B36289 CeMyoD protein - Caenorhabditis elegans
200.0 [0..1] [324..1]

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Predicted Domain #1
Region A:
Residues: [1-121]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNTETSTQSA PSDTYDTSIY YNSSPRVTAN DITTLTSFAA PAPQVLDYAN TQYDIYRNQP  60
   61 AYYLPSYAPT APTTFYSDFA NFNVTRSQDF ASVPAVANSS DVKPIIIKQE KSTPNATELI 120
  121 I

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [122-227]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QSRVDSQHED TTTSTAGGAG VGGPRRTKFV LSVDRRKAAT MRERRRLRKV NEAFEVVKQR  60
   61 TCPNPNQRLP KVEILRSAID YINNLERMLQ QAGKMTKIME QNQHLQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.69897
Match: 1mdyA
Description: Myod B/HLH domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.28018660287528 bayes_pls_golite062009
transcription regulator activity 1.87754990073909 bayes_pls_golite062009
DNA binding 1.73664400879211 bayes_pls_golite062009
transcription factor activity 1.6095946900662 bayes_pls_golite062009
nucleic acid binding 1.57122223638621 bayes_pls_golite062009
protein binding 0.78099405089238 bayes_pls_golite062009
transcription activator activity 0.314165294474 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [228-324]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTQQINGAPP HDYVTSSHFA SSSYNPENMF DDDDLTDSDD DRDHHKLGNA VDLRRRNSLD  60
   61 RLSRIVASIP NEEAMTDEQL LQPANDVIDG EKKLEML

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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Created and Maintained by: Michael Riffle