| Protein: | sir-2.1 |
| Organism: | Caenorhabditis elegans |
| Length: | 607 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for sir-2.1.
| Description | E-value | Query Range |
Subject Range |
|
|
428.0 | [0..1] | [607..1] |
|
Region A: Residues: [1-113] |
1 11 21 31 41 51
| | | | | |
1 MSRDSGNDSE VAVTHGEVQE ITEENPEIGS MHITQETDIS DAPETNTDSS RQRTESTTSV 60
61 SSESWQNNDE MMSNLRRAQR LLDDGATPLQ IIQQIFPDFN ASRIATMSEN AHF
|
| Detection Method: |  |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [114-388] |
1 11 21 31 41 51
| | | | | |
1 AILSDLLERA PVRQKLTNYN SLADAVELFK TKKHILVLTG AGVSVSCGIP DFRSKDGIYA 60
61 RLRSEFPDLP DPTAMFDIRY FRENPAPFYN FAREIFPGQF VPSVSHRFIK ELETSGRLLR 120
121 NYTQNIDTLE HQTGIKRVVE CHGSFSKCTC TRCGQKYDGN EIREEVLAMR VAHCKRCEGV 180
181 IKPNIVFFGE DLGREFHQHV TEDKHKVDLI VVIGSSLKVR PVALIPHCVD KNVPQILINR 240
241 ESLPHYNADI ELLGNCDDII RDICFSLGGS FTELI
|
| Detection Method: | |
| Confidence: | 68.09691 |
| Match: | 1j8fA |
| Description: | Sirt2 histone deacetylase |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| protein deacetylase activity | 9.15022242957651 | bayes_pls_golite062009 |
| histone deacetylase activity | 9.04876491350231 | bayes_pls_golite062009 |
| NAD-dependent protein deacetylase activity | 8.13038616303736 | bayes_pls_golite062009 |
| NAD-dependent histone deacetylase activity | 8.13038616303736 | bayes_pls_golite062009 |
| deacetylase activity | 8.11496387956068 | bayes_pls_golite062009 |
| histone deacetylase activity (H3-K14 specific) | 6.02509672218091 | bayes_pls_golite062009 |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides | 5.83127897351395 | bayes_pls_golite062009 |
| NAD-dependent histone deacetylase activity (H3-K9 specific) | 5.29340754009793 | bayes_pls_golite062009 |
| NAD-dependent histone deacetylase activity (H3-K14 specific) | 5.29340754009793 | bayes_pls_golite062009 |
| NAD-dependent histone deacetylase activity (H4-K16 specific) | 4.51070381823692 | bayes_pls_golite062009 |
| histone deacetylase activity (H3-K9 specific) | 3.4896257195243 | bayes_pls_golite062009 |
| transcription regulator activity | 2.9155913558118 | bayes_pls_golite062009 |
| DNA binding | 2.43141001866996 | bayes_pls_golite062009 |
| nucleic acid binding | 2.41433477472968 | bayes_pls_golite062009 |
| transcription repressor activity | 2.24657784428979 | bayes_pls_golite062009 |
| binding | 2.06552694538163 | bayes_pls_golite062009 |
| histone binding | 1.71445510915336 | bayes_pls_golite062009 |
| transcription corepressor activity | 1.64212790017753 | bayes_pls_golite062009 |
| protein binding | 1.52593340148652 | bayes_pls_golite062009 |
| nucleosome binding | 1.5125174755597 | bayes_pls_golite062009 |
| hydrolase activity | 1.43067365161346 | bayes_pls_golite062009 |
| transcription factor activity | 1.30143289828088 | bayes_pls_golite062009 |
| transcription factor binding | 1.14766678956419 | bayes_pls_golite062009 |
| tubulin deacetylase activity | 1.11434618720209 | bayes_pls_golite062009 |
| catalytic activity | 0.739210399081789 | bayes_pls_golite062009 |
| transcription cofactor activity | 0.54005617175343 | bayes_pls_golite062009 |
| transferase activity | 0.483523935618287 | bayes_pls_golite062009 |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds | 0.114062221123972 | bayes_pls_golite062009 |
| NAD+ ADP-ribosyltransferase activity | 0.0099486881187274 | bayes_pls_golite062009 |
|
Region A: Residues: [389-607] |
1 11 21 31 41 51
| | | | | |
1 TSYDSIMEQQ GKTKSQKPSQ NKRQLISQED FLNICMKEKR NDDSSDEPTL KKPRMSVADD 60
61 SMDSEKNNFQ EIQKHKSEDD DDTRNSDDIL KKIKHPRLLS ITEMLHDNKC VAISAHQTVF 120
121 PGAECSFDLE TLKLVRDVHH ETHCESSCGS SCSSNADSEA NQLSRAQSLD DFVLSDEDRK 180
181 NTIHLDLQRA DSCDGDFQYE LSETIDPETF SHLCEEMRI
|
| Detection Method: | |
Shown below is our most confident prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
