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View Structure Prediction Details

Protein: hex-1
Organism: Caenorhabditis elegans
Length: 555 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for hex-1.

Description E-value Query
Range
Subject
Range
gi|157768991 - gi|157768991|ref|XP_001676316.1| Hypothetical protein CBG14058 [Caenorhabditis briggsae AF16]
HEXA_CAEBR - Beta-hexosaminidase A OS=Caenorhabditis briggsae GN=hex-1 PE=3 SV=1
548.0 [0..1] [555..6]

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Predicted Domain #1
Region A:
Residues: [1-555]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRLLIPILIF ALITTAVTWF YGRDDPDRWS VGGVWPLPKK IVYGSKNRTI TYDKIGIDLG  60
   61 DKKDCDILLS MADNYMNKWL FPFPVEMKTG GTEDFIITVT VKDECPSGPP VHGASEEYLL 120
  121 RVSLTEAVIN AQTVWGALRA MESLSHLVFY DHKSQEYQIR TVEIFDKPRF PVRGIMIDSS 180
  181 RHFLSVNVIK RQLEIMSMNK LNVLHWHLVD SESFPYTSVK FPELHGVGAY SPRHVYSRED 240
  241 IADVIAFARL RGIRVIPEFD LPGHTSSWRG RKGFLTECFD EKGVETFLPN LVDPMNEANF 300
  301 DFISEFLEEV TETFPDQFLH LGGDEVSDYI VECWERNKKI RKFMEEKGFG NDTVLLENYF 360
  361 FEKLYKIVEN LKLKRKPIFW QEVFDNNIPD PNAVIHIWKG NTHEEIYEQV KNITSQNFPV 420
  421 IVSACWYLNY IKYGADWRDE IRGTAPSNSR YYYCDPTNFN GTVAQKELVW GGIAAIWGEL 480
  481 VDNTNIEARL WPRASAAAER LWSPAEKTQR AEDAWPRMHE LRCRLVSRGY RIQPNNNPDY 540
  541 CPFEFDEPPA TKTEL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 146.0
Match: 1o7aA
Description: Human beta-Hexosaminidase B
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
hydrolase activity, hydrolyzing O-glycosyl compounds 6.26329339735894 bayes_pls_golite062009
hydrolase activity, acting on glycosyl bonds 5.92180849080637 bayes_pls_golite062009
galactosidase activity 5.29959220339307 bayes_pls_golite062009
alpha-galactosidase activity 4.85819791163713 bayes_pls_golite062009
hydrolase activity 3.5336140444552 bayes_pls_golite062009
hexosaminidase activity 3.21852337137039 bayes_pls_golite062009
beta-N-acetylhexosaminidase activity 2.69072465526737 bayes_pls_golite062009
catalytic activity 1.85569074294201 bayes_pls_golite062009
glucosidase activity 1.85545420386612 bayes_pls_golite062009
alpha-glucosidase activity 1.00973231642658 bayes_pls_golite062009
signal transducer activity 0.934517587656668 bayes_pls_golite062009
molecular transducer activity 0.934517587656668 bayes_pls_golite062009
transporter activity 0.882190348056302 bayes_pls_golite062009
transmembrane transporter activity 0.696239852087965 bayes_pls_golite062009
binding 0.601963252939415 bayes_pls_golite062009
beta-glucuronidase activity 0.55376725638834 bayes_pls_golite062009
mannosidase activity 0.48536369022293 bayes_pls_golite062009
transferase activity, transferring hexosyl groups 0.266938437560648 bayes_pls_golite062009
substrate-specific transporter activity 0.223550370855368 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 7.36798954279472E-5 bayes_pls_golite062009

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