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View Structure Prediction Details

Protein: usp-14
Organism: Caenorhabditis elegans
Length: 489 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for usp-14.

Description E-value Query
Range		 Subject
Range
gi|967276 - gi|967276|gb|AAA74956.1| tRNA-guanine transglycosylase
 295.0 [0..1] [489..1]

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Predicted Domain #1
Region A:
Residues: [1-82] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPIVNVKWQK EKYVVEVDTS APPMVFKAQL FALTQVVPER QKVVIMGRTL GDDDWEGITI  60
   61 KENMTIMMMG SVGEIPKPPT VL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.30103
Match: 1wggA
Description: Solution Structure of the N-terminal Ubiquitin-like Domain of Mouse Ubiquitin Specific Protease 14 (USP14)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
small conjugating protein ligase activity 3.22676362920771 bayes_pls_golite062009
hydrolase activity 2.77871378503369 bayes_pls_golite062009
ubiquitin-protein ligase activity 2.46621820231139 bayes_pls_golite062009
acid-amino acid ligase activity 2.24025972049145 bayes_pls_golite062009
binding 2.19381585790185 bayes_pls_golite062009
protein tag 1.93603588492737 bayes_pls_golite062009
protein binding 1.84908810286528 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 1.54640383227873 bayes_pls_golite062009
SUMO ligase activity 0.58905960362002 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.536856055841234 bayes_pls_golite062009
kinase activity 0.506057697290914 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.410719674374641 bayes_pls_golite062009
nucleic acid binding 0.383121378043805 bayes_pls_golite062009
protein kinase activity 0.325253662829604 bayes_pls_golite062009
transferase activity 0.236208643697075 bayes_pls_golite062009
DNA binding 0.0840213088061073 bayes_pls_golite062009
transcription regulator activity 0.0485636215870291 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [83-489] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EKKQANRDKQ AEEISALYPC GLANLGNTCY FNSCVQMLKE VNELVLKPAE EMRIREHNDR  60
   61 LCHNLATLFN SLRDKDRALR SKGEPIKPFA AILTLSDSFP QFEKFKQQDA NECLVSIMSN 120
  121 VTRIYGLSGW NIESLFRIQT ETTMKCLESD EVSEKKVERN NQLTCYVNQD VRFLQTGIKA 180
  181 GFEEEMTRNS EELNRDAKWQ KNTQISRLPK YLTVNINRFF YKESTKTNAK ILKSVQFPMQ 240
  241 LDTYDLCSQE LKDKLVARRA DIKLEEDAKL ERELRKKVLD KEQGDKIFDD GVALPTAFED 300
  301 DAGSNNSGFY DLKGIITHKG RSSQDGHYVA WMRSSEDGKW RLFDDEHVTV VDEEAILKTS 360
  361 GGGDWHSAYV LLYEARVIKQ FPELPPAPVP TEVAADTAEP MEVSEKQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 45.522879
Match: 2aynA
Description: Structure of USP14, a proteasome-associated deubiquitinating enzyme
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity 7.38847948226412 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 7.21002260103248 bayes_pls_golite062009
endopeptidase activity 6.57191549077589 bayes_pls_golite062009
cysteine-type peptidase activity 6.54685807643041 bayes_pls_golite062009
small conjugating protein-specific protease activity 6.39247995905454 bayes_pls_golite062009
ubiquitin-specific protease activity 5.91394445088241 bayes_pls_golite062009
hydrolase activity 4.82615927403291 bayes_pls_golite062009
ubiquitin thiolesterase activity 4.1832081096766 bayes_pls_golite062009
thiolester hydrolase activity 2.96735553959103 bayes_pls_golite062009
SUMO-specific protease activity 2.65263825059319 bayes_pls_golite062009
cysteine-type endopeptidase activity 1.95802900199539 bayes_pls_golite062009
binding 1.3276268995308 bayes_pls_golite062009
catalytic activity 1.05972260874031 bayes_pls_golite062009
protein binding 0.854677025220204 bayes_pls_golite062009
NEDD8-specific protease activity 0.687958315289315 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 0.495951820083869 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.467924587720185 bayes_pls_golite062009
nucleic acid binding 0.439226369799415 bayes_pls_golite062009
calcium-dependent cysteine-type endopeptidase activity 0.196538841514154 bayes_pls_golite062009
DNA binding 0.168761518285256 bayes_pls_golite062009
transferase activity 0.0852393573521809 bayes_pls_golite062009
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