| Protein: | daf-4 |
| Organism: | Caenorhabditis elegans |
| Length: | 744 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for daf-4.
| Description | E-value | Query Range |
Subject Range |
|
|
446.0 | [0..1] | [744..1] |
|
Region A: Residues: [1-261] |
1 11 21 31 41 51
| | | | | |
1 MNQKGTVRLK ALVLICLPLF LIATPVPVAV TEDDRQDRIE SEAAEKEWAN TLVSKVAQSN 60
61 GTGTIKVSAP AKPTLRRMDN EEDEVISIEC VYYDEMECEK SGDCEITKKT CYSEAHLKAV 120
121 GCLAVFGLPT QEINSTEPYL KVDKPQYKSL GCMPYQHADS MNCENESSCR QGRSFRGGIG 180
181 MCCCSTNNCN MPDLIEMVNP SLKKDSDNSA LLWASTPSNM DLESLDKFPF YWIIIIALSV 240
241 ILCIALLILA YVGWKFQQNK K
|
| Detection Method: |  |
| Confidence: | 15.0 |
| Match: | 1ivoA |
| Description: | EGF receptor extracellular domain; EGF receptor Cys-rich domains |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| growth factor binding | 6.33296746316446 | bayes_pls_golite062009 |
| insulin-like growth factor binding | 4.68807086347794 | bayes_pls_golite062009 |
| binding | 3.10942625145915 | bayes_pls_golite062009 |
| protein binding | 3.04595153576805 | bayes_pls_golite062009 |
| insulin-like growth factor I binding | 2.64764959452188 | bayes_pls_golite062009 |
| transmembrane receptor activity | 2.11274485218746 | bayes_pls_golite062009 |
| receptor activity | 2.04770371945982 | bayes_pls_golite062009 |
| insulin-like growth factor II binding | 1.94025491221585 | bayes_pls_golite062009 |
| phosphotransferase activity, alcohol group as acceptor | 1.83752933098717 | bayes_pls_golite062009 |
| kinase activity | 1.80864815034082 | bayes_pls_golite062009 |
| signal transducer activity | 1.716940423168 | bayes_pls_golite062009 |
| molecular transducer activity | 1.716940423168 | bayes_pls_golite062009 |
| enzyme regulator activity | 1.68559458458962 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 1.6818630115957 | bayes_pls_golite062009 |
| protein kinase activity | 1.64316913174221 | bayes_pls_golite062009 |
| enzyme activator activity | 1.49158544951255 | bayes_pls_golite062009 |
| glycoprotein binding | 1.41359665103303 | bayes_pls_golite062009 |
| transferase activity | 1.3977021765186 | bayes_pls_golite062009 |
| protein tyrosine kinase activity | 0.625443680166071 | bayes_pls_golite062009 |
| catalytic activity | 0.271811389148807 | bayes_pls_golite062009 |
| phosphatase activator activity | 0.234175951765568 | bayes_pls_golite062009 |
| protein tyrosine phosphatase activator activity | 0.193211593927368 | bayes_pls_golite062009 |
|
Region A: Residues: [262-610] |
1 11 21 31 41 51
| | | | | |
1 EEIKKQQKIK FDMEKTDALE AGNVPLVEPE EEMIEMVETP KELPITDFQL ISKGRFGKVF 60
61 KAQYTPDSGE KRLVAVKKLN EFQKASFLAE KRIFDELNEY PKWYKSIVEF VCAEKIGDEY 120
121 WIVTEFHERL SLYELLKNNV ISITSANRII MSMIDGLQFL HDDRPYFFGH PKKPIIHRDI 180
181 KSKNILVKSD MTTCIADFGL ARIYSYDIEQ SDLLGQVGTK RYMSPEMLEG ATEFTPTAFK 240
241 AMDVYSMGLV MWEVISRTKL HQTDEPPNYQ MPFQVIGFDP TIGLMRNYVV SKKERPQWRD 300
301 EIIKHEYMSL LKKVTEEMWD PEACARITAG CAFARVWNHI MSSPDSSEG
|
| Detection Method: | |
| Confidence: | 53.522879 |
| Match: | 1b6cB |
| Description: | Type I TGF-beta receptor R4 |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| activin receptor activity | 7.18922615745589 | bayes_pls_golite062009 |
| activin binding | 7.11944534332244 | bayes_pls_golite062009 |
| receptor signaling protein serine/threonine kinase activity | 6.41728494915949 | bayes_pls_golite062009 |
| activin receptor activity, type I | 6.1393596497059 | bayes_pls_golite062009 |
| phosphotransferase activity, alcohol group as acceptor | 5.49988294224815 | bayes_pls_golite062009 |
| protein kinase activity | 5.4586557943719 | bayes_pls_golite062009 |
| kinase activity | 5.3287080791198 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 4.96052051118534 | bayes_pls_golite062009 |
| cyclin-dependent protein kinase activity | 4.62392503670521 | bayes_pls_golite062009 |
| protein serine/threonine kinase activity | 4.46381887831481 | bayes_pls_golite062009 |
| transferase activity | 3.97138602499442 | bayes_pls_golite062009 |
| transmembrane receptor protein kinase activity | 3.40140621607334 | bayes_pls_golite062009 |
| transmembrane receptor protein serine/threonine kinase activity | 3.37600307408153 | bayes_pls_golite062009 |
| transforming growth factor beta receptor activity | 3.37600307408153 | bayes_pls_golite062009 |
| transmembrane receptor activity | 3.1965684217331 | bayes_pls_golite062009 |
| transmembrane receptor protein tyrosine kinase activity | 2.97315540587667 | bayes_pls_golite062009 |
| receptor activity | 2.96273889901429 | bayes_pls_golite062009 |
| molecular transducer activity | 2.85730457922199 | bayes_pls_golite062009 |
| signal transducer activity | 2.85730457922199 | bayes_pls_golite062009 |
| protein tyrosine kinase activity | 2.8153155526437 | bayes_pls_golite062009 |
| binding | 2.74863538127007 | bayes_pls_golite062009 |
| growth factor binding | 2.61235080252818 | bayes_pls_golite062009 |
| transforming growth factor beta receptor activity, type I | 2.57601476622612 | bayes_pls_golite062009 |
| protein binding | 2.276111749106 | bayes_pls_golite062009 |
| receptor signaling protein activity | 2.10379226653669 | bayes_pls_golite062009 |
| insulin receptor activity | 2.08642574110801 | bayes_pls_golite062009 |
| fibroblast growth factor binding | 2.00819948109978 | bayes_pls_golite062009 |
| ATP binding | 1.97600611746091 | bayes_pls_golite062009 |
| adenyl ribonucleotide binding | 1.93596671856664 | bayes_pls_golite062009 |
| adenyl nucleotide binding | 1.90928021591891 | bayes_pls_golite062009 |
| phosphoinositide 3-kinase binding | 1.90879495821405 | bayes_pls_golite062009 |
| fibroblast growth factor 1 binding | 1.82118598657067 | bayes_pls_golite062009 |
| purine ribonucleotide binding | 1.65732943334212 | bayes_pls_golite062009 |
| ribonucleotide binding | 1.65726906484847 | bayes_pls_golite062009 |
| purine nucleotide binding | 1.63763394711025 | bayes_pls_golite062009 |
| nucleotide binding | 1.63195828048121 | bayes_pls_golite062009 |
| transcription regulator activity | 1.56748951434625 | bayes_pls_golite062009 |
| transforming growth factor beta binding | 1.46877913443522 | bayes_pls_golite062009 |
| nucleic acid binding | 1.46547714006072 | bayes_pls_golite062009 |
| MAP kinase kinase activity | 1.42275431028856 | bayes_pls_golite062009 |
| DNA binding | 1.35333135345112 | bayes_pls_golite062009 |
| catalytic activity | 1.21655087018101 | bayes_pls_golite062009 |
| transporter activity | 1.11833481501707 | bayes_pls_golite062009 |
| transcription factor activity | 1.10928254946881 | bayes_pls_golite062009 |
| insulin binding | 1.03564126441771 | bayes_pls_golite062009 |
| SMAD binding | 1.02108562119195 | bayes_pls_golite062009 |
| general RNA polymerase II transcription factor activity | 0.99838484913572 | bayes_pls_golite062009 |
| transcription activator activity | 0.997272622653026 | bayes_pls_golite062009 |
| transmembrane transporter activity | 0.97575992765505 | bayes_pls_golite062009 |
| transcription repressor activity | 0.959888295228949 | bayes_pls_golite062009 |
| MAP kinase activity | 0.81943579965027 | bayes_pls_golite062009 |
| amine binding | 0.783881819862438 | bayes_pls_golite062009 |
| cytoskeletal protein binding | 0.748533008006377 | bayes_pls_golite062009 |
| substrate-specific transporter activity | 0.705905455086486 | bayes_pls_golite062009 |
| insulin receptor substrate binding | 0.57617745233877 | bayes_pls_golite062009 |
| protein serine/threonine/tyrosine kinase activity | 0.48345772948903 | bayes_pls_golite062009 |
| substrate-specific transmembrane transporter activity | 0.450699332958421 | bayes_pls_golite062009 |
| follistatin binding | 0.407208295811976 | bayes_pls_golite062009 |
| RNA polymerase II transcription factor activity | 0.401250804041384 | bayes_pls_golite062009 |
| structural constituent of muscle | 0.399773397398032 | bayes_pls_golite062009 |
| magnesium ion binding | 0.393328812780268 | bayes_pls_golite062009 |
| PTB domain binding | 0.384625387464921 | bayes_pls_golite062009 |
| insulin receptor binding | 0.379040209226037 | bayes_pls_golite062009 |
| MAP kinase kinase kinase activity | 0.37115026509016 | bayes_pls_golite062009 |
| transforming growth factor beta receptor activity, type II | 0.365530951355731 | bayes_pls_golite062009 |
| fibroblast growth factor receptor activity | 0.34434685718027 | bayes_pls_golite062009 |
| structure-specific DNA binding | 0.318153468064373 | bayes_pls_golite062009 |
| peptide hormone binding | 0.312169974523858 | bayes_pls_golite062009 |
| glycoprotein binding | 0.2984932537448 | bayes_pls_golite062009 |
| glycosaminoglycan binding | 0.294256794094724 | bayes_pls_golite062009 |
| kinase binding | 0.26752427107238 | bayes_pls_golite062009 |
| protein complex binding | 0.239339759110451 | bayes_pls_golite062009 |
| polysaccharide binding | 0.229808864843639 | bayes_pls_golite062009 |
| cytokine binding | 0.17817111033393 | bayes_pls_golite062009 |
| cell adhesion molecule binding | 0.150740450460731 | bayes_pls_golite062009 |
| ion transmembrane transporter activity | 0.148194101970458 | bayes_pls_golite062009 |
| cytokine receptor binding | 0.144440612194652 | bayes_pls_golite062009 |
| protein kinase C activity | 0.0795689006739899 | bayes_pls_golite062009 |
| tubulin binding | 0.0510156114567444 | bayes_pls_golite062009 |
| receptor serine/threonine kinase binding | 0.0123645889643007 | bayes_pls_golite062009 |
| protein kinase binding | 0.00674998152095019 | bayes_pls_golite062009 |
| nucleoside-triphosphatase activity | 0.0040394359628233 | bayes_pls_golite062009 |
| SH2 domain binding | 2.96656737540424E-4 | bayes_pls_golite062009 |
|
Region A: Residues: [611-744] |
1 11 21 31 41 51
| | | | | |
1 YHSGSSMKNR GVDDVEQSEK PEGIEEMQHY HASSPSKRQH PSPNPFFDSC PPPPPIPVIL 60
61 ENGGILQPDN AEPEPEELPD LPIVEKIYDI ATNMLFSREE LDLMNAQRQV EYEAGADTRA 120
121 STPTPSGTFG TFTT
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
