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View Structure Prediction Details

Protein: cep-1
Organism: Caenorhabditis elegans
Length: 644 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for cep-1.

Description E-value Query
Range
Subject
Range
gi|39595432, gi|... - gi|39595432|emb|CAE60470.1| Hypothetical protein CBG04081 [Caenorhabditis briggsae], gi|187036264|em...
gi|157746221 - gi|157746221|ref|XP_001668207.1| Hypothetical protein CBG04081 [Caenorhabditis briggsae AF16]
977.0 [0..2] [641..4]

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Predicted Domain #1
Region A:
Residues: [1-216]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEPDDSQLSD ILKDARIPDS QDIGVNLTQN LSFDTVQKMI DGVFTPIFSQ GTEDSLEKDI  60
   61 LKTPGISTIY NGILGNGEET KKRTPKISDA FEPDLNTSGD VFDSDKSEDG LMNDESYLSN 120
  121 TTLSQVVLDS QKYEYLRVRT EEEQQLVIEK RARERFIRKS MKIAEETALS YENDGSRELS 180
  181 ETMTQKVTQM DFTETNVPFD GNDESSNLAV RVQSDM

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [217-432]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NLNEDCEKWM EIDVLKQKVA KSSDMAFAIS SEHEKYLWTK MGCLVPIQVK WKLDKRHFNS  60
   61 NLSLRIRFVK YDKKENVEYA IRNPRSDVMK CRSHTEREQH FPFDSFFYIR NSEHEFSYSA 120
  121 EKGSTFTLIM YPGAVQANFD IIFMCQEKCL DLDDRRKTMC LAVFLDDENG NEILHAYIKQ 180
  181 VRIVAYPRRD WKNFCEREDA KQKDFRFPEL PAYKKA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 111.0
Match: 1t4wA
Description: Structural Differences in the DNA Binding Domains of Human p53 and its C. elegans Ortholog Cep-1: Structure of C. elegans Cep-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.48951024516114 bayes_pls_golite062009
transcription regulator activity 2.08461887975954 bayes_pls_golite062009
DNA binding 2.00590712396281 bayes_pls_golite062009
protein binding 1.89777739609026 bayes_pls_golite062009
nucleic acid binding 1.81190570165535 bayes_pls_golite062009
transcription factor activity 1.47792643319772 bayes_pls_golite062009
sequence-specific DNA binding 0.83908184260106 bayes_pls_golite062009
transcription activator activity 0.70688258731336 bayes_pls_golite062009
structure-specific DNA binding 0.67114633230283 bayes_pls_golite062009
double-stranded DNA binding 0.60405934196774 bayes_pls_golite062009
DNA strand annealing activity 0.59003565500643 bayes_pls_golite062009
single-stranded DNA binding 0.41353824553911 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [433-644]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SLESINIKQE VNLENMFNVT NTTAQMEPST SYSSPSNSNN RKRFLNECDS PNNDYTMMHR  60
   61 TPPVTGYASR LHGCVPPIET EHENCQSPSM KRSRCTNYSF RTLTLSTAEY TKVVEFLARE 120
  121 AKVPRYTWVP TQVVSHILPT EGLERFLTAI KAGHDSVLFN ANGIYTMGDM IREFEKHNDI 180
  181 FERIGIDSSK LSKYYEAFLS FYRIQEAMKL PK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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Created and Maintained by: Michael Riffle