| Protein: | pkc-2 |
| Organism: | Caenorhabditis elegans |
| Length: | 680 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for pkc-2.
| Description | E-value | Query Range |
Subject Range |
|
|
605.0 | [0..1] | [680..1] |
|
Region A: Residues: [1-92] |
1 11 21 31 41 51
| | | | | |
1 MSLSTNSSVK EDEAQRIEGK AFVRRGALRQ KNVHEIKSHK FIARFFKQPT FCSHCKDFLW 60
61 GITKQGFQCQ VCTLVVHKRC HEFVNFACPG AD
|
| Detection Method: |  |
| Confidence: | 7.30103 |
| Match: | 2db6A |
| Description: | No description for 2db6A was found. |
|
Region A: Residues: [93-189] |
1 11 21 31 41 51
| | | | | |
1 KGVDTDDPRQ QHKWKVQTYS SPTFCDHCGS LLYGILHQGM KCQSCDTNVH HRCVKNVPNM 60
61 CGTDNTEKRG RLRIEAHIEN DQLTIKILEA KNLIPMD
|
| Detection Method: | |
| Confidence: | 9.69897 |
| Match: | 1tbnA |
| Description: | NMR STRUCTURE OF A PROTEIN KINASE C-G PHORBOL-BINDING DOMAIN, MINIMIZED AVERAGE STRUCTURE |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| general RNA polymerase II transcription factor activity | 3.71782887289779 | bayes_pls_golite062009 |
| calmodulin-dependent protein kinase activity | 3.58912725568461 | bayes_pls_golite062009 |
| transcription regulator activity | 2.86705824967236 | bayes_pls_golite062009 |
| binding | 2.79128751898373 | bayes_pls_golite062009 |
| protein binding | 2.34145982999922 | bayes_pls_golite062009 |
| phosphotransferase activity, alcohol group as acceptor | 2.10625597744594 | bayes_pls_golite062009 |
| DNA binding | 2.06132216820898 | bayes_pls_golite062009 |
| kinase activity | 2.03632850156074 | bayes_pls_golite062009 |
| nucleic acid binding | 1.91441035614579 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 1.8531437045627 | bayes_pls_golite062009 |
| protein kinase activity | 1.62921423829738 | bayes_pls_golite062009 |
| transferase activity | 1.4550521488922 | bayes_pls_golite062009 |
| transcription factor activity | 1.39657429296564 | bayes_pls_golite062009 |
| GTPase regulator activity | 1.39167263636091 | bayes_pls_golite062009 |
| nucleoside-triphosphatase regulator activity | 1.37139209958305 | bayes_pls_golite062009 |
| signal transducer activity | 1.25507073225414 | bayes_pls_golite062009 |
| molecular transducer activity | 1.25507073225414 | bayes_pls_golite062009 |
| RNA polymerase II transcription factor activity | 1.10685156896266 | bayes_pls_golite062009 |
| protein serine/threonine kinase activity | 0.956859696337723 | bayes_pls_golite062009 |
| enzyme regulator activity | 0.911061212692491 | bayes_pls_golite062009 |
| guanyl-nucleotide exchange factor activity | 0.907368864863833 | bayes_pls_golite062009 |
| small GTPase regulator activity | 0.661240850692236 | bayes_pls_golite062009 |
| kinase binding | 0.494958567742569 | bayes_pls_golite062009 |
| cation binding | 0.416345209135028 | bayes_pls_golite062009 |
| metal ion binding | 0.416345209135028 | bayes_pls_golite062009 |
| ion binding | 0.411417584934096 | bayes_pls_golite062009 |
| myosin heavy chain kinase activity | 0.386296468226541 | bayes_pls_golite062009 |
| catalytic activity | 0.194464246602439 | bayes_pls_golite062009 |
|
Region A: Residues: [190-612] |
1 11 21 31 41 51
| | | | | |
1 PNGLSDPYVK CKLIPEDSGC KSKQKTKTLR ATLNPQWNET FTYKLLPGDK DRRLSIEVWD 60
61 WDRTSRNDFM GSLSFGISEL MKEAASGWYK LLSAEEGEFY NINITPEYDE DMEKVRKKMN 120
121 ENFITRDNSS SKPKDPAAPR ASTLPLGSSN HNVIKASDFN FLTVLGKGSF GKVLLGEQKT 180
181 TKELFAIKVL KKDVIIQDDD VECTMTEKRV LALPEKPSFL VALHSCFQTM DRLYFVMEFV 240
241 NGGDLMYQIQ QVGKFKEPVA VFYAAEIAVG LFFLHSKGII YRDLKLDNVM LERDGHIKIT 300
301 DFGMCKENIF GDATTKTFCG TPDYIAPEII LYQPYGKSVD WWAYGVLLFE MLAGQPPFDG 360
361 EDEDELFTAI TEHNVSYPKS LSKEAVSLCK ALLIKNPSKR LGCTGDDESA SRDIKEHPFF 420
421 RRI
|
| Detection Method: | |
| Confidence: | 59.69897 |
| Match: | 2ptkA |
| Description: | CHICKEN SRC TYROSINE KINASE |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| phosphotransferase activity, alcohol group as acceptor | 5.49988294224815 | bayes_pls_golite062009 |
| protein kinase activity | 5.4586557943719 | bayes_pls_golite062009 |
| kinase activity | 5.3287080791198 | bayes_pls_golite062009 |
| cyclic nucleotide-dependent protein kinase activity | 4.97855712164511 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 4.96052051118534 | bayes_pls_golite062009 |
| cAMP-dependent protein kinase activity | 4.66277812893755 | bayes_pls_golite062009 |
| protein serine/threonine kinase activity | 4.46381887831481 | bayes_pls_golite062009 |
| calmodulin-dependent protein kinase activity | 4.31938467136214 | bayes_pls_golite062009 |
| transferase activity | 3.97138602499442 | bayes_pls_golite062009 |
| phosphoinositide 3-kinase binding | 3.43994026029707 | bayes_pls_golite062009 |
| transmembrane receptor protein tyrosine kinase activity | 3.41480681854114 | bayes_pls_golite062009 |
| transmembrane receptor protein kinase activity | 3.40140621607334 | bayes_pls_golite062009 |
| SH2 domain binding | 3.03401803018883 | bayes_pls_golite062009 |
| protein tyrosine kinase activity | 2.8153155526437 | bayes_pls_golite062009 |
| binding | 2.74863538127007 | bayes_pls_golite062009 |
| transmembrane receptor activity | 2.59526003830791 | bayes_pls_golite062009 |
| ion transmembrane transporter activity | 2.52531786618214 | bayes_pls_golite062009 |
| cation transmembrane transporter activity | 2.46424348876434 | bayes_pls_golite062009 |
| signal transducer activity | 2.40586892801446 | bayes_pls_golite062009 |
| molecular transducer activity | 2.40586892801446 | bayes_pls_golite062009 |
| receptor activity | 2.39311927684508 | bayes_pls_golite062009 |
| substrate-specific transmembrane transporter activity | 2.37122853419919 | bayes_pls_golite062009 |
| acetylcholine receptor activator activity | 2.31137729067208 | bayes_pls_golite062009 |
| protein binding | 2.276111749106 | bayes_pls_golite062009 |
| tubulin binding | 2.18641675163967 | bayes_pls_golite062009 |
| cytoskeletal protein binding | 2.12615078788254 | bayes_pls_golite062009 |
| receptor signaling protein activity | 2.10379226653669 | bayes_pls_golite062009 |
| insulin binding | 2.0719180171079 | bayes_pls_golite062009 |
| ATP binding | 1.97600611746091 | bayes_pls_golite062009 |
| PTB domain binding | 1.96099803532698 | bayes_pls_golite062009 |
| ubiquitin-protein ligase activity | 1.94085498993561 | bayes_pls_golite062009 |
| adenyl ribonucleotide binding | 1.93596671856664 | bayes_pls_golite062009 |
| adenyl nucleotide binding | 1.90928021591891 | bayes_pls_golite062009 |
| metal ion transmembrane transporter activity | 1.9016235206634 | bayes_pls_golite062009 |
| microtubule binding | 1.88110801192607 | bayes_pls_golite062009 |
| actin binding | 1.87817875565699 | bayes_pls_golite062009 |
| receptor signaling protein serine/threonine kinase activity | 1.81249386965144 | bayes_pls_golite062009 |
| molecular adaptor activity | 1.81145713371725 | bayes_pls_golite062009 |
| small conjugating protein ligase activity | 1.74206248731815 | bayes_pls_golite062009 |
| purine ribonucleotide binding | 1.65732943334212 | bayes_pls_golite062009 |
| ribonucleotide binding | 1.65726906484847 | bayes_pls_golite062009 |
| purine nucleotide binding | 1.63763394711025 | bayes_pls_golite062009 |
| nucleotide binding | 1.63195828048121 | bayes_pls_golite062009 |
| insulin receptor substrate binding | 1.62657794525303 | bayes_pls_golite062009 |
| SH3/SH2 adaptor activity | 1.59474164216385 | bayes_pls_golite062009 |
| transcription regulator activity | 1.56748951434625 | bayes_pls_golite062009 |
| JUN kinase kinase kinase kinase activity | 1.55257528159541 | bayes_pls_golite062009 |
| growth factor binding | 1.53863828216563 | bayes_pls_golite062009 |
| phosphoinositide 3-kinase activity | 1.5013287968167 | bayes_pls_golite062009 |
| 1-phosphatidylinositol-3-kinase activity | 1.43713739644553 | bayes_pls_golite062009 |
| MAP kinase kinase activity | 1.42275431028856 | bayes_pls_golite062009 |
| DNA binding | 1.35333135345112 | bayes_pls_golite062009 |
| general RNA polymerase II transcription factor activity | 1.32254739984688 | bayes_pls_golite062009 |
| GTPase activity | 1.28660784978431 | bayes_pls_golite062009 |
| gamma-tubulin binding | 1.28511591054866 | bayes_pls_golite062009 |
| kinase binding | 1.26086833316556 | bayes_pls_golite062009 |
| ErbB-3 class receptor binding | 1.25765701903393 | bayes_pls_golite062009 |
| epidermal growth factor receptor binding | 1.24312972088703 | bayes_pls_golite062009 |
| acid-amino acid ligase activity | 1.2266791546014 | bayes_pls_golite062009 |
| catalytic activity | 1.21655087018101 | bayes_pls_golite062009 |
| structural constituent of muscle | 1.19908793854422 | bayes_pls_golite062009 |
| nucleic acid binding | 1.16049201286103 | bayes_pls_golite062009 |
| transporter activity | 1.11833481501707 | bayes_pls_golite062009 |
| transcription factor activity | 1.10928254946881 | bayes_pls_golite062009 |
| structural molecule activity | 1.10436308210353 | bayes_pls_golite062009 |
| transmembrane receptor protein serine/threonine kinase activity | 1.10045286406485 | bayes_pls_golite062009 |
| transforming growth factor beta receptor activity | 1.10045286406485 | bayes_pls_golite062009 |
| protein kinase binding | 1.06030596516506 | bayes_pls_golite062009 |
| cation channel activity | 1.04999722123563 | bayes_pls_golite062009 |
| phosphoinositide 3-kinase regulator activity | 1.03150090191995 | bayes_pls_golite062009 |
| transmembrane transporter activity | 0.97575992765505 | bayes_pls_golite062009 |
| cyclin-dependent protein kinase activity | 0.959360414036299 | bayes_pls_golite062009 |
| transcription repressor activity | 0.889321498544699 | bayes_pls_golite062009 |
| transcription activator activity | 0.846644791435606 | bayes_pls_golite062009 |
| protein binding, bridging | 0.83823250804321 | bayes_pls_golite062009 |
| MAP kinase activity | 0.81943579965027 | bayes_pls_golite062009 |
| actin filament binding | 0.794152600084 | bayes_pls_golite062009 |
| fibroblast growth factor receptor activity | 0.75189004129952 | bayes_pls_golite062009 |
| substrate-specific transporter activity | 0.705905455086486 | bayes_pls_golite062009 |
| vinculin binding | 0.666656406096231 | bayes_pls_golite062009 |
| structural constituent of cytoskeleton | 0.612883428421652 | bayes_pls_golite062009 |
| insulin receptor activity | 0.585036697436369 | bayes_pls_golite062009 |
| ErbB-2 class receptor binding | 0.547121592096699 | bayes_pls_golite062009 |
| activin binding | 0.510364757301021 | bayes_pls_golite062009 |
| protein serine/threonine/tyrosine kinase activity | 0.48345772948903 | bayes_pls_golite062009 |
| enzyme binding | 0.46284745266176 | bayes_pls_golite062009 |
| protein kinase C activity | 0.41587987561486 | bayes_pls_golite062009 |
| magnesium ion binding | 0.393328812780268 | bayes_pls_golite062009 |
| 3-phosphoinositide-dependent protein kinase binding | 0.372842462336059 | bayes_pls_golite062009 |
| MAP kinase kinase kinase activity | 0.37115026509016 | bayes_pls_golite062009 |
| structure-specific DNA binding | 0.318153468064373 | bayes_pls_golite062009 |
| phosphotyrosine binding | 0.311079584914389 | bayes_pls_golite062009 |
| channel activity | 0.287189255116606 | bayes_pls_golite062009 |
| passive transmembrane transporter activity | 0.287189255116606 | bayes_pls_golite062009 |
| insulin receptor binding | 0.266450215230107 | bayes_pls_golite062009 |
| substrate-specific channel activity | 0.261869836686301 | bayes_pls_golite062009 |
| ion channel activity | 0.241519346930618 | bayes_pls_golite062009 |
| protein complex binding | 0.239339759110451 | bayes_pls_golite062009 |
| photoreceptor activity | 0.187612589250841 | bayes_pls_golite062009 |
| peptide binding | 0.118578378753757 | bayes_pls_golite062009 |
| transforming growth factor beta receptor activity, type I | 0.0506751594607393 | bayes_pls_golite062009 |
| cation binding | 0.046173055856133 | bayes_pls_golite062009 |
| metal ion binding | 0.046173055856133 | bayes_pls_golite062009 |
| ion binding | 0.0389662058697694 | bayes_pls_golite062009 |
| fibroblast growth factor 1 binding | 0.0386657159233388 | bayes_pls_golite062009 |
| MAP kinase kinase kinase kinase activity | 0.01826424351081 | bayes_pls_golite062009 |
| nucleoside-triphosphatase activity | 0.0040394359628233 | bayes_pls_golite062009 |
|
Region A: Residues: [613-680] |
1 11 21 31 41 51
| | | | | |
1 DWFKIETRQI QPPFKPKLKS ADDTSNFDSE FTHEVPKLTP IDRLFLMNLD QTEFEGFSFV 60
61 NPEYVQEC
|
| Detection Method: | |
| Confidence: | 92.0 |
| Match: | 2i0eA |
| Description: | No description for 2i0eA was found. |
